Article
Engineering, Environmental
Afeng Yang, Xia Dong, Yun Bai, Shupei Sheng, Yan Zhang, Tianjun Liu, Dunwan Zhu, Feng Lv
Summary: The study introduced a doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells (DC) co-laden hydrogel system for cancer chemo-assisted immunotherapy. The combination effectively induced a strong CTL killing effect, increased effector T cell infiltration, alleviated the immunosuppressive microenvironment, and maximized the immune effect for improving chemo-assisted immunotherapy. The fluorescence imaging tracking provided insight into the in vivo process of immune cells, chemotherapeutic drugs, and immune adjuvants for efficient therapy guidance.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Qiurong Zhu, Fang Sun, Tianliang Li, Mengxue Zhou, Jiayi Ye, Aiyan Ji, Hui Wang, Chunyong Ding, Hao Chen, Zhiai Xu, Haijun Yu
Summary: A versatile prodrug nanoparticle for second near-infrared (NIR-II) fluorescence imaging-guided combinatory immunotherapy of colorectal cancer has been reported. The nanoparticles show high intratumoral accumulation and trigger immunogenic cell death of the tumor cells, elicit antitumor immune response in a spatiotemporally controllable manner. The combination of the nanoparticle-based photothermal therapy/chemotherapy with programmed death ligand 1 blockade significantly promotes intratumoral infiltration of cytotoxic T lymphocytes and eradicates CRC tumors.
Article
Chemistry, Multidisciplinary
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Summary: Immune checkpoint blockade therapies have made a significant impact on cancer treatment, but many patients do not respond to these therapies. Researchers have developed a combination chemoimmunotherapy nanosystem that includes a gemcitabine prodrug nanoparticle decorated with an anti-PD-L1 antibody and a STING agonist. This nanosystem enhances drug delivery to ICB-refractory tumors, activates CD8+ T cell responses, and transforms low-immunogenic tumors into inflamed tumors. In multiple mouse tumor models, the triple-combination nanovesicles induce a strong antitumor immune response and result in regression of large tumors and reduction in metastatic burden. These findings provide a basis for developing chemoimmunotherapeutic strategies for treating ICB-nonresponsive tumors.
Article
Chemistry, Multidisciplinary
Yupeng Wang, Jie Yu, Zhijian Luo, Qiankun Shi, Guanglong Liu, Fan Wu, Zhizhang Wang, Yubin Huang, Dongfang Zhou
Summary: An engineered biomimetic nano-RBC system utilizing hemoglobin is developed to deliver chemotherapy drugs and oxygen, effectively reprogramming the tumor immunosuppressive microenvironment. This strategy targets tumor-associated macrophages and alleviates tumor hypoxia, enhancing the antitumor immune response and inhibiting tumor metastasis and recurrence.
ADVANCED MATERIALS
(2021)
Review
Oncology
Robby Barnestein, Loick Galland, Laura Kalfeist, Francois Ghiringhelli, Sylvain Ladoire, Emeric Limagne
Summary: With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of care in cancer management has evolved rapidly. However, immunotherapy is not currently beneficial for all patients. Recent research has found that besides their direct cytotoxic effects on cancer cells, several conventional chemotherapeutic (CT) drugs and agents used in targeted therapies (TT) can also enhance antitumor immunity by promoting the elimination or inactivation of suppressive immune cells.
Article
Nanoscience & Nanotechnology
Ziyuan Huang, Yuying Chen, Jiulong Zhang, Wenpan Li, Menghao Shi, Mingxi Qiao, Xiuli Zhao, Haiyang Hu, Dawei Chen
Summary: The study introduces a laser/glutathione-activatable nanosystem for highly efficient immunotherapy by promoting tumor penetration and uptake. This nanosystem containing oxaliplatin, phthalocyanine, and IDO1 inhibitor triggers ROS production at the tumor site, leading to drug release, inhibition of tumor growth, and induction of immunogenic cell death. The research suggests that in deep tumors, this laser/glutathione-activatable drug delivery system can enhance immunogenic cell death and reverse immune suppression physiopathology.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yunkun Li, Yahui Wu, Zaixiang Fang, Yuxin Zhang, Haitao Ding, Long Ren, Lu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: This study develops a target ligand-modified dendritic nanomedicine for tumor chemo-immunotherapy. The nanomedicine promotes cellular internalization, penetration, and drug release. It triggers immune response and remodels the tumor immune microenvironment, resulting in enhanced therapeutic effect.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Xiaoxue Xie, Yi Feng, Hanxi Zhang, Qingqing Su, Ting Song, Geng Yang, Ningxi Li, Xiaodan Wei, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Xiaojuan Zhang, Guixue Wang, Yiyao Liu, Hong Yang
Summary: This study reported a tumor acidity-responsive nanovaccine that can remodel the immunosuppressive tumor microenvironment, enhance recruitment of tumor infiltrating lymphocytes, improve antigen presentation and drug transportation efficiency, leading to tumor growth inhibition and long-term tumor inhibition.
BIOACTIVE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Yanyu Huang, Hsiao-Chi Wang, Junwei Zhao, Ming-Heng Wu, Tsung-Chieh Shih
Summary: Evasion of immune surveillance is a hallmark of tumor progression, with tumor-secreted Gal-1 binding to immune cell receptors and suppressing immune cell function in the tumor microenvironment, contributing to tumor immune escape. Therapeutics targeting Gal-1 are being explored as a potential strategy to overcome this immune suppression in tumors.
Article
Chemistry, Multidisciplinary
Abd Al-Wali Mohammed M. Japir, Wendong Ke, Junjie Li, Jean Felix Mukerabigwi, Alhadi Ibrahim, Yuheng Wang, Xiang Li, Qinghao Zhou, Fathelrahman Mohammed, Zhishen Ge
Summary: Combination chemo-immunotherapy of cancers has shown significant synergistic antitumor effects by enhancing immune response rates and therapeutic efficacy. However, it is often limited by immune-related adverse events and systemic toxicity. This study demonstrates an efficient nanofactory-directed enzyme prodrug chemo-immunotherapy based on enzyme-loaded tumor-dilatable polymersomes, offering a promising paradigm for enhanced treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, Xueying Liu, Xiaotong Yang, Tao Gong, Yuan Huang, Huile Gao
Summary: An intelligent responsive liposome is developed for safer and more effective combination immunotherapy. It targets tumor tissues using a polypeptide inhibitor of PD-1 signal pathway (AUNP-12) and a matrix metalloproteinase-2 (MMP-2) cleavable peptide (GPLGVRGD). This study offers a potentially appealing paradigm for targeted drug delivery in breast cancer.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
Zhaopei Guo, Yingying Hu, Mengyao Zhao, Kai Hao, Pan He, Huayu Tian, Xuesi Chen, Meiwan Chen
Summary: The combination of chemo-immunotherapy is challenging due to poor tumor penetration of therapeutic agents. A new strategy using a helix self-assembly camptothecin prodrug combined with plasmids to down-regulate tumor surface PD-L1 expression and degrade ECM showed significant inhibition of tumor growth and prevention of recurrence.
Article
Nanoscience & Nanotechnology
Qingfei Zhang, Gaizhen Kuang, Yunru Yu, Xiaoya Ding, Haozhen Ren, Weijian Sun, Yuanjin Zhao
Summary: Research has shown that using novel hierarchical hydrogel microparticles (M-DDP) to deliver drugs can release them at the tumor site, reducing systemic toxicity. This approach not only induces immunogenic cell death in tumor cells, but also suppresses immunosuppressive cells within the tumor. These hierarchical microparticles exhibit superior synergistic antitumor efficacy in cell experiments.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Article
Immunology
Zhuomao Mo, Daiyuan Liu, Dade Rong, Shijun Zhang
Summary: This study identified hypoxic patients with immunosuppressive HCC and established a hypoxia-associated score that could effectively predict patients' survival in two independent cohorts. The study provides further evidence of the connection between hypoxia signals in patients and immunosuppression in HCC, with potential implications for future predictive models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hairong Wang, Yu Chao, He Zhao, Xiuxia Zhou, Fuyong Zhang, Zheng Zhang, Zhiheng Li, Jian Pan, Jian Wang, Qian Chen, Zhuang Liu
Summary: In this study, a BBB-crossing copolymer was successfully fabricated using a choline analogue MPC, leading to efficient delivery of ICB therapy in a glioma model and significantly prolonging animal survival.
Article
Chemistry, Multidisciplinary
Guangbao Yang, Dongdong Wang, Soo Zeng Fiona Phua, Anivind Kaur Bindra, Cheng Qian, Rui Zhang, Liang Cheng, Guofeng Liu, Hongwei Wu, Zhuang Liu, Yanli Zhao
Summary: A nanoscale therapeutic system was fabricated by coassembly of human serum albumin and glucose oxidase, which effectively eliminates tumor cells through the combination of catalysis and chemotherapeutic prodrug conversion, demonstrating high therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Jiaying Li, Fengxuan Han, Jinjin Ma, Huan Wang, Jun Pan, Guangbao Yang, He Zhao, Jiayue Zhao, Jinbo Liu, Zhuang Liu, Bin Li
Summary: This study visualizes the spatial and temporal profile of ROS in the bone injury microenvironment using photoacoustic imaging technique for the first time. It demonstrates that the levels of H2O2 increase significantly upon bone injury, peak at a certain stage of bone healing, and gradually decrease towards baseline level. Regulating ROS with hollow manganese dioxide nanoparticles (hMNPs) can promote cell growth and repair in bone injury environments.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Biomedical
Minjiang Chen, Gaofeng Shu, Xiuling Lv, Xiaoling Xu, Chenying Lu, Enqi Qiao, Shiji Fang, Lin Shen, Nannan Zhang, Jun Wang, Chunmiao Chen, Jingjing Song, Zhuang Liu, Yongzhong Du, Jiansong Ji
Summary: A PT/DOX-MS microsphere was developed in this study, which showed superior efficacy in treating HCC by co-delivering doxorubicin and PT-2385. The microsphere exhibited multiple mechanisms to inhibit tumor growth, including blocking tumor cell cycle, promoting cell apoptosis, and inhibiting tumor angiogenesis.
Article
Chemistry, Multidisciplinary
Lele Sun, Fengyun Shen, Zijian Xiong, He Yang, Ziliang Dong, Jian Xiang, Qingyang Gu, Qunsheng Ji, Chunhai Fan, Zhuang Liu
Summary: This study successfully constructed lymphocyte-based homologous targeting aAPCs (LC-aAPCs) that mimic the characteristics of natural antigen-presenting cells through lipid-DNA-mediated noninvasive live cell surface engineering. These LC-aAPCs can optimize T cell activation and effectively inhibit tumor growth.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Yu Hao, Lei Zhang, Ziliang Dong, Chunjie Wang, Yu Chao, Dongxu Zhao, Yujie Zhu, Zhijuan Yang, Nailin Yang, Yikai Han, Liangzhu Feng, Zhuang Liu
Summary: This article proposes an alternative locoregional treatment strategy using percutaneously implanted catalytic couple fueled by orally administrated ethanol to effectively ablate tumors. It is shown that this strategy has a great inhibitory effect on liver and breast tumors in mice and rats, comparable to the traditional percutaneous ethanol injection therapy.
Article
Chemistry, Multidisciplinary
Yu Yang, Bo Liu, Yuan Liu, Jingqi Chen, Yujia Sun, Xiaoshu Pan, Jun Xu, Shujuan Xu, Zhuang Liu, Weihong Tan
Summary: Metal X Frameworks (MXFs) constructed from metal ions and biomacromolecules via coordination interactions exhibit crystalline structures and diverse functionalities. This study showcases the application of a specific MXF composed of Hf4+ and CpG oligodeoxynucleotides in high-Z elements-enhanced photon radiotherapy and immune responses, leading to efficient tumor suppression. The findings highlight the potential of MXFs in fabricating various functional materials and stimulating systemic immune responses through localized radiotherapy.
Review
Chemistry, Multidisciplinary
Wei-Hai Chen, Qi-Wen Chen, Qian Chen, Chunyan Cui, Shun Duan, Yongyuan Kang, Yang Liu, Yun Liu, Wali Muhammad, Shiqun Shao, Chengqiang Tang, Jinqiang Wang, Lei Wang, Meng-Hua Xiong, Lichen Yin, Kuo Zhang, Zhanzhan Zhang, Xu Zhen, Jun Feng, Changyou Gao, Zhen Gu, Chaoliang He, Jian Ji, Xiqun Jiang, Wenguang Liu, Zhuang Liu, Huisheng Peng, Youqing Shen, Linqi Shi, Xuemei Sun, Hao Wang, Jun Wang, Haihua Xiao, Fu-Jian Xu, Zhiyuan Zhong, Xian-Zheng Zhang, Xuesi Chen
Summary: This review summarizes the recent advances in the synthesis and application of biomedical polymers, discussing their property-function relationship for corresponding biomedical applications. It highlights emerging bioactive polymers as potential biomaterials for cancer precision therapy. The challenges and outlook for the development of more efficient, healthier, and safer biomedical polymers are also discussed.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Microbiology
Chen Xue, Jiaxin Zheng, Guangli Wang, Liang Feng, Feng Li
Summary: A functional strain BD2 with improved degradation efficiency of chlorothalonil (CTN) and carbendazim (MBC) was obtained through protoplast fusion, and the genetic relationship between BD2 and its parental strains was confirmed by SEM, RAPD, and 16S rRNA gene sequences analysis. BD2 showed better degradation rates of CTN and MBC compared to its parental strains, indicating its potential for bioremediation of CTN and MBC contaminated sites.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yikai Han, Ziliang Dong, Chunjie Wang, Quguang Li, Yu Hao, Zhijuan Yang, Wenjun Zhu, Yunyun Zhang, Zhuang Liu, Liangzhu Feng
Summary: In this study, a pH-responsive Fe2+ delivery nanocarrier was prepared to suppress tumor growth through inducing ferroptosis. The results showed that the nanocarrier exhibited high efficacy in tumor chemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng, Zhuang Liu
Summary: The study demonstrates that Ca2+-surplus alginate hydrogel can enhance microwave ablation (MWA) therapy by increasing heating efficiency and inducing immunogenic cell death. Synergizing with Mn2+, it can also strengthen antitumor immunity and suppress tumor growth. This finding is of great significance for clinical translation.
Article
Chemistry, Multidisciplinary
Ziliang Dong, Chunjie Wang, Yimou Gong, Yunyun Zhang, Qin Fan, Yu Hao, Quguang Li, Yumin Wu, Xiaoyan Zhong, Kai Yang, Liangzhu Feng, Zhuang Liu
Summary: This study presents the preparation of a multifunctional fluorinated calcium carbonate nanoregulator that can reverse tumor immunosuppression and potentiate radiotherapy by chemically modulating tumor hypoxic and acidic microenvironments.
Article
Chemistry, Multidisciplinary
Rui Shi, Ziliang Dong, Chongqing Ma, Renfei Wu, Rui Lv, Sidi Liu, Yijin Ren, Zhuang Liu, Henny C. van der Mei, Henk J. Busscher, Jian Liu
Summary: PEGylation of MNPs is crucial for enhancing their uptake in E. coli, leading to high-yield magnetic harvesting of OMVs. The magnetically harvested OMVs can be targeted to specific delivery sites in the body, showing potential for drug delivery applications.
Article
Engineering, Biomedical
Qiaofeng Li, Yu Chao, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu
Summary: This study developed pH-responsive lipid-coated calcium phosphate nanoparticles (LCP NPs) that co-loaded with disulfiram (DSF) and copper ions (Cu2+). The nanoparticles selectively accumulated in tumors and released DSF and Cu2+ in the acidic tumor microenvironment, inducing cytotoxicity and immunogenic cell death (ICD) of cancer cells. These findings demonstrate the potential of repurposing DSF as a new ICD inducer for improved tumor-responsive therapy and enhanced immune checkpoint blockade (ICB) therapy.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
