Review
Biochemistry & Molecular Biology
Irfan Ullah, Hashir Ali Awan, Alifiya Aamir, Mufaddal Najmuddin Diwan, Renato de Filippis, Sana Awan, Muhammad Irfan, Michele Fornaro, Antonio Ventriglio, Federica Vellante, Mauro Pettorruso, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardis
Summary: Schizophrenia is a major psychotic disorder affecting nearly 23.6 million people globally. Multiple risk factors, including genetic, environmental, and epigenetic factors, have been identified, with inflammation playing a significant role in the development of schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ellen Ji, Danny Boerrigter, Helen Q. Cai, David Lloyd, Jason Bruggemann, Maryanne O'Donnell, Cherrie Galletly, Andrew Lloyd, Dennis Liu, Rhoshel Lenroot, Thomas W. Weickert, Cynthia Shannon Weickert
Summary: This study found that levels of complement factors, receptors, and regulators are significantly increased in patients with schizophrenia. Higher peripheral inflammation index scores are associated with reduced cortical thickness in the temporal lobe. These findings suggest that aberrant complement levels may play an important role in the pathophysiology of schizophrenia.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Fengmei Fan, Junchao Huang, Shuping Tan, Zhiren Wang, Yanli Li, Song Chen, Hui Li, Stephanie Hare, Xiaoming Du, Fude Yang, Baopeng Tian, Peter Kochunov, Yunlong Tan, L. Elliot Hong
Summary: Treatment resistance in schizophrenia is associated with reduced cortical thickness in specific brain regions. These regions include the right caudal middle frontal gyrus, superior frontal cortex, fusiform gyrus, pars opercularis of the inferior frontal cortex, and supramarginal cortex. The reductions in cortical thickness in these regions are significantly correlated with cognitive deficits. Moreover, cortical abnormalities in the right caudal middle frontal gyrus, superior frontal cortex, and pars opercularis of the inferior frontal cortex mediate the effects of cognitive deficits on treatment resistance.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Psychology, Clinical
Deepak K. Sarpal, Goda Tarcijonas, Finnegan J. Calabro, William Foran, Gretchen L. Haas, Beatriz Luna, Vishnu P. Murty
Summary: This study examined the background connectivity in individuals with first-episode psychosis during executive processing and found that there were impairments in connectivity, potentially undermining cognitive control capacities in these patients.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Andrew J. Watson, Annalisa Giordano, John Suckling, Thomas R. E. Barnes, Nusrat Husain, Peter B. Jones, Carl R. Krynicki, Stephen M. Lawrie, Shon Lewis, Naghmeh Nikkheslat, Carmine M. Pariante, Rachel Upthegrove, Bill Deakin, Paola Dazzan, Eileen M. Joyce
Summary: This study identified cognitive subtypes based on IQ in patients with early-phase schizophrenia-spectrum disorder. The compromised IQ subtype was associated with smaller brain volume and higher levels of low-grade inflammation markers. This adds validity to the existence of a neurodevelopmental subtype of schizophrenia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Kim T. Mueser, Rachel F. Sussman, Nicole R. Detore, Elizabeth S. Eberlin, Susan R. Mcgurk
Summary: Impaired cognitive functioning is a core feature of schizophrenia, and early intervention services have been shown to improve symptoms and functioning in first episode psychosis. This study evaluated the long-term effects of early intervention services on cognitive functioning in first episode psychosis patients. The results showed that while there were no improvements in cognitive functioning for older patients, younger patients showed significant improvements in working memory. Overall, interventions targeting cognition may be necessary to enhance cognitive functioning in most first episode psychosis patients.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Isabel Ruiz-Delgado, Berta Moreno-Kuestner, Monica Garcia-Medina, Maria Luisa Barrigon, Fermin Gonzalez-Higueras, Raguel Lopez-Carrilero, Irene Barrios-Mellado, Ana Barajas, Esther Pousa, Esther Lorente-Rovira, Eva Grasa, Jordi Cid, Paula Barrau-Sastre, Steffen Moritz, Susana Ochoa, Spanish Metacognition Group
Summary: This multicenter randomized clinical trial found that Metacognitive Training (MCT) is an effective psychological intervention for improving memory, attention, and executive function in first-episode psychosis patients.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Noelia Rodriguez-Perez, Rosa Ayesa-Arriola, Victor Ortiz-Garcia de la Foz, Esther Setien-Suero, Diana Tordesillas-Gutierrez, Benedicto Crespo-Facorro
Summary: Cortical thickness was found to be thinner in patients with first-episode psychosis, especially those with poor functional outcomes. No correlations were found between cortical thickness measurements and clinical variables.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Haakon R. Hol, Marianne M. Flak, Linda Chang, Gro Christine Christensen Lohaugen, Knut Jorgen Bjuland, Lars M. Rimol, Andreas Engvig, Jon Skranes, Thomas Ernst, Bengt-Ove Madsen, Susanne S. Hernes
Summary: In patients with MCI, both adaptive and non-adaptive WM training did not lead to improved cortical thickness. However, individuals with LMX1A-AA genotype showed increased cortical thickness trajectories or lack of decrease post-training.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Liliana Laskaris, Sam Mancuso, Cynthia Shannon Weickert, Andrew Zalesky, Gursharan Chana, Cassandra Wannan, Chad Bousman, Bernhard T. Baune, Patrick McGorry, Christos Pantelis, Vanessa L. Cropley
Summary: The study found differential relationships between peripheral inflammatory markers and select brain regions in first-episode psychosis (FEP) and healthy controls, although no relationships were detected in chronic schizophrenia. Specifically, frontal thickness was positively associated with certain cytokine levels in the healthy control group, while pro-inflammatory cytokines were associated with lower total cortical volume in the FEP group. Longitudinal investigations are needed to determine how the relationship between brain structure and peripheral inflammation may change over time.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Health Care Sciences & Services
Suheda Kaya, Gulay Tasci, Nulufer Kilic, Husna Karadayi, Filiz Ozsoy, Murad Atmaca
Summary: The aim of this study was to examine the relationship between peripheral inflammatory markers and aggression and impulsivity in schizophrenia patients with and without criminal histories. The results showed that inflammatory agents were significantly increased in forensic schizophrenia patients with high aggression scores, suggesting a potential link between inflammation and violence and criminal behavior.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychology, Clinical
Cecilie K. Lemvigh, Rachel M. Brouwer, Christos Pantelis, Maria H. Jensen, Rikke W. Hilker, Christian S. Legind, Simon J. Anhoj, Trevor W. Robbins, Barbara J. Sahakian, Birte Y. Glenthoj, Birgitte Fagerlund
Summary: This study found that certain cognitive functions have a heritability and are associated with schizophrenia. These functions may serve as endophenotypes for schizophrenia and provide a basis for exploring genes that are common to cognition and schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Farivar Fathian, Rolf Gjestad, Rune A. Kroken, Else-Marie Loberg, Solveig Klaebo Reitan, W. Wolfgang Fleichhacker, Maria Rettenbacher, Tor K. Larsen, Inge Joa, Lena Antonsen Stabell, Eirik Kjelby, Igne Sinkevicute, Renata Alisauskiene, Vidar M. Steen, Erik Johnsen
Summary: This study examined the effects of amisulpride, aripiprazole, and olanzapine on CRP levels in patients with schizophrenia spectrum disorder. The results showed that these drugs have different effects on CRP levels, which are also modified by previous antipsychotic exposure.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
S. S. Gangadin, M. Germann, L. D. de Witte, K. A. Gelderman, R. C. W. Mandl, I. E. C. Sommer
Summary: The association between C4A and brain morphology differs between recent-onset SSD patients and healthy controls.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Psychiatry
Andrew J. Watson, Lauren Harrison, Antonio Preti, Til Wykes, Matteo Cella
Summary: The trajectory of cognitive deficits in the years following psychosis onset remains debated, with small improvements observed in early psychosis patients that are likely due to practice effects. Longitudinal studies over longer follow-up periods are needed to further evaluate cognitive decline and improvement, as well as the role of social cognition in early psychosis.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Elysha Ringin, Vanessa Cropley, Andrew Zalesky, Jason Bruggemann, Suresh Sundram, Cynthia Shannon Weickert, Thomas W. Weickert, Chad A. Bousman, Christos Pantelis, Tamsyn E. Van Rheenen
Summary: The study found no significant interactions between smoking and cognitive or brain morphology in SSD patients, with the exception of a thinner left posterior cingulate in smokers compared to non-smokers. While several main effects of smoking were initially significant in cognitive, volume and thickness analyses, they did not survive FDR correction.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Gabriella A. M. Blokland, Jakob Grove, Chia-Yen Chen, Chris Cotsapas, Stuart Tobet, Robert Handa, David St Clair, Todd Lencz, Bryan J. Mowry, Sathish Periyasamy, Murray J. Cairns, Paul A. Tooney, Jing Qin Wu, Brian Kelly, George Kirov, Patrick F. Sullivan, Aiden Corvin, Brien P. Riley, Tonu Esko, Lili Milani, Erik G. Jonsson, Aarno Palotie, Hannelore Ehrenreich, Martin Begemann, Agnes Steixner-Kumar, Pak C. Sham, Nakao Iwata, Daniel R. Weinberger, Pablo Gejman, Alan R. Sanders, Joseph D. Buxbaum, Dan Rujescu, Ina Giegling, Bettina Konte, Annette M. Hartmann, Elvira Bramon, Robin M. Murray, Michele T. Pato, Jimmy Lee, Ingrid Melle, Espen Molden, Roel A. Ophoff, Andrew McQuillin, Nicholas J. Bass, Rolf Adolfsson, Anil K. Malhotra, Nicholas G. Martin, Janice M. Fullerton, Philip B. Mitchell, Peter R. Schofield, Andreas J. Forstner, Franziska Degenhardt, Sabrina Schaupp, Ashley L. Comes, Manolis Kogevinas, Jose Guzman-Parra, Andreas Reif, Fabian Streit, Lea Sirignano, Sven Cichon, Maria Grigoroiu-Serbanescu, Joanna Hauser, Jolanta Lissowska, Fermin Mayoral, Bertram Muller-Myhsok, Thomas G. Schulze, Markus M. Nothen, Marcella Rietschel, John Kelsoe, Marion Leboyer, Stephane Jamain, Bruno Etain, Frank Bellivier, John B. Vincent, Martin Alda, Claire O'Donovan, Pablo Cervantes, Joanna M. Biernacka, Mark Frye, Susan L. McElroy, Laura J. Scott, Eli A. Stahl, Mikael Landen, Marian L. Hamshere, Olav B. Smeland, Srdjan Djurovic, Arne E. Vaaler, Ole A. Andreassen, Bernhard T. Baune, Tracy Air, Martin Preisig, Rudolf Uher, Douglas F. Levinson, Myrna M. Weissman, James B. Potash, Jianxin Shi, James A. Knowles, Roy H. Perlis, Susanne Lucae, Dorret Boomsma, Brenda W. J. H. Penninx, Jouke-Jan Hottenga, Eco J. C. de Geus, Gonneke Willemsen, Yuri Milaneschi, Henning Tiemeier, Hans J. Grabe, Alexander Teumer, Sandra Van der Auwera, Uwe Volker, Steven P. Hamilton, Patrik K. E. Magnusson, Alexander Viktorin, Divya Mehta, Niamh Mullins, Mark J. Adams, Gerome Breen, Andrew M. McIntosh, Cathryn M. Lewis, David M. Hougaard, Merete Nordentoft, Ole Mors, Preben B. Mortensen, Thomas Werge, Thomas D. Als, Anders D. Borglum, Tracey L. Petryshen, Jordan W. Smoller, Jill M. Goldstein
Summary: The study found significant sex-dependent genetic risk in schizophrenia, major depressive disorder, and bipolar disorder, with implications for genes related to neuronal development, immune functions, and vascular functions across and within these disorders. This suggests substantial genetic overlap between sexes in mood and psychotic disorders, with sex-specific effects enriched for genes involved in various physiological functions.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Niamh Mullins, JooEun Kang, Adrian Campos, Jonathan R. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark Adams, Swapnil Awasthi, Michael Ganda, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi-Chung Chen, Steven Crawford, Scott Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernandez-Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai-Gwo Hwu, Sonia Jain, Stephane Jamain, Susana Jimenez-Murcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly L. Klump, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih-Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Richard M. Myers, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Tracy M. Air, Martin Alda, Lars Alfredsson, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, Maria Soler Artigas, Sandra Van der Auwera, M. Helena Azevedo, Nicholas Bass, Claiton H. D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, Rosa Bosch, David L. Braff, Richard Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Sven Cichon, Aiden Corvin, Nicholas Craddock, David Craig, Franziska Degenhardt, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark Frye, Janice M. Fullerton, Justine M. Gatt, Pablo Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Steven P. Hamilton, Marian L. Hamshere, Annette Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A. Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Bettina Konte, Marie-Odile Krebs, Mikael Lander, Jacob Lawrence, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Susanne Lucae, Fermin Mayoral, Susan L. McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Sarah E. Medland, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Gunnar Morken, Preben Bo Mortensen, Bertram Mueller-Myhsok, Caroline Nievergelt, Vishwajit Nimgaonkar, Markus M. Noethen, Michael C. O'Donovan, Roel A. Ophoff, Michael J. Owen, Carlos Pato, Michele T. Pato, Brenda W. J. H. Penninx, Jonathan Pimm, Giorgio Pistis, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribases, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A. Rouleau, Diego L. Rovaris, Dan Rujescu, Cristina Sanchez-Mora, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley Shyn, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund J. S. Sonuga-Barke, Gianfranco Spalletta, John S. Strauss, Beata Swiatkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar-Ribo, John B. Vincent, Henry Voelzke, James T. R. Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Allison E. Ashley-Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin McMahon, David W. Oslin, Xuejun Qin, Esben Agerbo, Anders D. Borglum, Gerome Breen, Annette Erlangsen, Tonu Esko, Joel Gelernter, David M. Hougaard, Ronald C. Kessler, Henry R. Kranzler, Qingqin S. Li, Nicholas G. Martin, Andrew M. McIntosh, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David Porteous, Robert J. Ursano, Danuta Wasserman, Thomas Werge, David C. Whiteman, Cynthia M. Bulik, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po-Hsiu Kuo, Cathryn M. Lewis, J. John Mann, Miguel E. Renteria, Daniel J. Smith, Eli A. Stahl, Murray B. Stein, Fabian Streit, Virginia Willour, Douglas M. Ruderfer
Summary: A genome-wide association study identified significant genetic loci associated with suicide attempts, particularly one locus on chromosome 7 which is implicated in risk-taking behavior, smoking, and insomnia. The study also revealed strong genetic correlations between suicide attempts and psychiatric disorders, as well as other nonpsychiatric traits like smoking, pain, and lower socioeconomic status. Conditioning on psychiatric disorders reduced the genetic correlations between suicide attempts and psychiatric disorders, indicating a shared biology with nonpsychiatric risk factors.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Caitlin E. Murphy, Adam K. Walker, Maryanne O'Donnell, Cherrie Galletly, Andrew R. Lloyd, Dennis Liu, Cynthia Shannon Weickert, Thomas W. Weickert
Summary: Elevated levels of pro-inflammatory cytokines and CRP are associated with impairments in cognitive abilities and more severe psychiatric symptoms in schizophrenia. NF-kappa B pathway genes are increased in the brains of schizophrenia patients and are closely related to neuroinflammation. IL-1 beta and IFN-gamma mRNA levels were increased in patients, while IL-6, IL-8, IL-18, and TNF-alpha mRNA levels did not differ. TLR4 and RelB appear to be more related to inflammatory status, while IKK beta and NIK are unique to high inflammation patients.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Yash Patel, Jean Shin, Christoph Abe, Ingrid Agartz, Clara Alloza, Dag Alnaes, Sonia Ambrogi, Linda A. Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Bandeira, Zeynep Basgoze, Renata Basso Cupertino, Claiton H. D. Bau, Jochen Bauer, Sarah Baumeister, Fabio Bernardoni, Alessandro Bertolino, Caterina del Mar Bonnin, Daniel Brandeis, Silvia Brem, Jason Bruggemann, Robin Bulow, Juan R. Bustillo, Sara Calderoni, Rosa Calvo, Erick J. Canales-Rodriguez, Dara M. Cannon, Susanna Carmona, Vaughan J. Carr, Stanley V. Catts, Sneha Chenji, Qian Hui Chew, David Coghill, Colm G. Connolly, Annette Conzelmann, Alexander R. Craven, Benedicto Crespo-Facorro, Kathryn Cullen, Andreas Dahl, Udo Dannlowski, Christopher G. Davey, Christine Deruelle, Covadonga M. Diaz-Caneja, Katharina Dohm, Stefan Ehrlich, Jeffery Epstein, Tracy Erwin-Grabner, Lisa T. Eyler, Jennifer Fedor, Jacqueline Fitzgerald, William Foran, Judith M. Ford, Lydia Fortea, Paola Fuentes-Claramonte, Janice Fullerton, Lisa Furlong, Louise Gallagher, Bingchen Gao, Si Gao, Jose M. Goikolea, Ian Gotlib, Roberto Goya-Maldonado, Hans J. Grabe, Melissa Green, Eugenio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Jan Haavik, Tim Hahn, Ben J. Harrison, Walter Heindel, Frans Henskens, Dirk J. Heslenfeld, Eva Hilland, Pieter J. Hoekstra, Sarah Hohmann, Nathalie Holz, Fleur M. Howells, Jonathan C. Ipser, Neda Jahanshad, Babette Jakobi, Andreas Jansen, Joost Janssen, Rune Jonassen, Anna Kaiser, Vasiliy Kaleda, James Karantonis, Joseph A. King, Tilo Kircher, Peter Kochunov, Sheri-Michelle Koopowitz, Mikael Landen, Nils Inge Landro, Stephen Lawrie, Irina Lebedeva, Beatriz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Daniel H. Mathalon, Colm McDonald, Andrew McIntosh, Susanne Meinert, Patricia T. Michie, Philip Mitchell, Ana Moreno-Alcazar, Bryan Mowry, Filippo Muratori, Leila Nabulsi, Igor Nenadic, Ruth O'Gorman Tuura, Jaap Oosterlaan, Bronwyn Overs, Christos Pantelis, Mara Parellada, Jose C. Pariente, Paul Pauli, Giulio Pergola, Francesco Maria Piarulli, Felipe Picon, Fabrizio Piras, Edith Pomarol-Clotet, Clara Pretus, Yann Quide, Joaquim Radua, J. Antoni Ramos-Quiroga, Paul E. Rasser, Andreas Reif, Alessandra Retico, Gloria Roberts, Susan Rossell, Diego Luiz Rovaris, Katya Rubia, Matthew Sacchet, Josep Salavert, Raymond Salvador, Salvador Sarro, Akira Sawa, Ulrich Schall, Rodney Scott, Pierluigi Selvaggi, Tim Silk, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Dan J. Stein, Olaf Steinstrater, Aleks Stolicyn, Yoichiro Takayanagi, Leanne Tamm, Maria Tavares, Alexander Teumer, Katharina Thiel, Sophia I. Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Michela Tosetti, Anne Uhlmann, Tamsyn Van Rheenen, Javier Vazquez-Bourgon, Meike W. Vernooij, Eduard Vieta, Oscar Vilarroya, Cynthia Weickert, Thomas Weickert, Lars T. Westlye, Heather Whalley, David Willinger, Alexandra Winter, Katharina Wittfeld, Tony T. Yang, Yuliya Yoncheva, Jende L. Zijlmans, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan Buitelaar, Christopher R. K. Ching, Ole A. Andreassen, Elena Pozzi, Dick Veltman, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, F. Xavier Castellanos, Zdenka Pausova, Paul Thompson, Tomas Paus
Summary: The study found that group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices across 11 cortical regions. These differences were associated with interregional profiles of prenatal cell-specific gene expression, implying that prenatal cell-specific processes may lead to deviations from typical brain development and vulnerability to mental illness. Additionally, genes coexpressed with radial glia and endothelial and mural cells were enriched with genes related to known pre/perinatal risk factors for psychosis, supporting a neurodevelopmental model of mental illness vulnerability.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Ellen Ji, Danny Boerrigter, Helen Q. Cai, David Lloyd, Jason Bruggemann, Maryanne O'Donnell, Cherrie Galletly, Andrew Lloyd, Dennis Liu, Rhoshel Lenroot, Thomas W. Weickert, Cynthia Shannon Weickert
Summary: This study found that levels of complement factors, receptors, and regulators are significantly increased in patients with schizophrenia. Higher peripheral inflammation index scores are associated with reduced cortical thickness in the temporal lobe. These findings suggest that aberrant complement levels may play an important role in the pathophysiology of schizophrenia.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Clinical Neurology
Steffen Moritz, Mahesh Menon, Ryan Balzan, Todd S. Woodward
Summary: This article provides an overview and retrospective on metacognitive training for psychosis (MCT), discussing its initial development and subsequent improvements and expansions. The efficacy of MCT in treating schizophrenia has been confirmed through meta-analyses, leading to its inclusion in national treatment guidelines. Efforts have also been made to enhance dissemination and accessibility through the creation of culturally sensitive language versions and e-learning courses.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Cynthia Haidee Tran, Cynthia Shannon Weickert, Thomas Wesley Weickert, Duncan Sinclair
Summary: Early life stress has long-lasting impacts on brain regions involved in dopamine neurotransmission, changing the trophic environment and potentially altering responsiveness to subsequent stressful events in a sex-specific pattern.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Constantinos Constantinides, Laura K. M. Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M. Diaz-Caneja, Gary Donohoe, Stefan Du Plessis, Jesse Edmond, Stefan Ehrlich, Robin Emsley, Lisa T. Eyler, Paola Fuentes-Claramonte, Foivos Georgiadis, Melissa Green, Amalia Guerrero-Pedraza, Minji Ha, Tim Hahn, Frans A. Henskens, Laurena Holleran, Stephanie Homan, Philipp Homan, Neda Jahanshad, Joost Janssen, Ellen Ji, Stefan Kaiser, Vasily Kaleda, Minah Kim, Woo-Sung Kim, Matthias Kirschner, Peter Kochunov, Yoo Bin Kwak, Jun Soo Kwon, Irina Lebedeva, Jingyu Liu, Patricia Mitchie, Stijn Michielse, David Mothersill, Bryan Mowry, Victor Ortiz-Garcia de la Foz, Christos Pantelis, Giulio Pergola, Fabrizio Piras, Edith Pomarol-Clotet, Adrian Preda, Yann Quide, Paul E. Rasser, Kelly Rootes-Murdy, Raymond Salvador, Marina Sangiuliano, Salvador Sarro, Ulrich Schall, Andre Schmidt, Rodney J. Scott, Pierluigi Selvaggi, Kang Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Sophia Thomopoulos, David Tomecek, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Therese van Amelsvoort, Javier Vazquez-Bourgon, Daniela Vecchio, Aristotle Voineskos, Cynthia S. Weickert, Thomas Weickert, Paul M. Thompson, Lianne Schmaal, Theo G. M. van Erp, Jessica Turner, James H. Cole, Danai Dima, Esther Walton
Summary: Schizophrenia patients show evidence of advanced brain ageing, which is not associated with clinical characteristics.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Alexandra May, Ryan Balzan, Anne Sved Williams, Tracey D. Wade, Sarah Marie Paranjothy
Summary: Perinatal borderline personality disorder (BPD) and complex post-traumatic stress disorder (cPTSD) are associated with impaired interpersonal functioning and risk of intergenerational transmission. However, there is a lack of evaluation for interventions targeting these disorders. This systematic review examines the literature on interventions for perinatal BPD and cPTSD, finding limited evidence but suggesting positive effects of Dialectical Behavioural Therapy and multimodal therapeutic approaches. However, more research is needed to establish robust conclusions and determine the feasibility of implementing intensive interventions.
ARCHIVES OF WOMENS MENTAL HEALTH
(2023)
Article
Psychology, Clinical
Ryan P. Balzan, Madeline Gilder, Matthew Thompson, Tracey D. Wade
Summary: This pilot study aimed to assess the feasibility and initial efficacy of the metacognitive training for eating disorders (MCT-ED) program in adolescents with anorexia nervosa (AN). The results showed that the MCT-ED condition had a low treatment attrition rate and received positive evaluation from participants. Significant differences were observed between the MCT-ED group and the waitlist controls in terms of perfectionism and eating disorder pathology at post-intervention and 3-month follow-up.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Multidisciplinary Sciences
Dick Schijven, Merel C. Postema, Masaki Fukunaga, Junya Matsumoto, Kenichiro Miura, Sonja M. C. de Zwarte, Neeltje E. M. van Haren, Wiepke Cahn, Hilleke E. Hulshoff Pol, Rene S. Kahn, Rosa Ayesa-Arriola, Victor Ortiz-Garcia de la Foz, Diana Tordesillas-Gutierrez, Javier Vazquez-Bourgon, Benedicto Crespo-Facorro, Dag Alnaes, Andreas Dahl, Lars T. Westlye, Ingrid Agartz, Ole A. Andreassen, Erik G. Jonsson, Peter Kochunov, Jason M. Bruggemann, Stanley V. Catts, Patricia T. Michie, Bryan J. Mowry, Yann Quide, Paul E. Rasser, Ulrich Schall, Rodney J. Scott, Vaughan J. Carr, Melissa J. Green, Frans A. Henskens, Carmel M. Loughland, Christos Pantelis, Cynthia Shannon Weickert, Thomas W. Weickert, Lieuwe De Haan, Katharina Brosch, Julia-Katharina Pfarr, Kai G. Ringwald, Frederike Stein, Andreas Jansen, Tilo T. J. Kircher, Igor Nenadic, Bernd Kramer, Oliver Gruber, Theodore D. Satterthwaite, Juan Bustillo, Daniel H. Mathalon, Adrian Preda, Vince D. Calhoun, Judith M. Ford, Steven G. Potkin, Jingxu Chen, Yunlong Tan, Zhiren Wang, Hong Xiang, Fengmei Fan, Fabio Bernardoni, Stefan Ehrlich, Paola Fuentes-Claramonte, Maria Angeles Garcia-Leon, Amalia Guerrero-Pedraza, Raymond Salvador, Salvador Sarro, Edith Pomarol-Clotet, Valentina Ciullo, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Gianfranco Spalletta, Stijn Michielse, Therese van Amelsvoort, Erin W. Dickie, Aristotle N. Voineskos, Kang Sim, Simone Ciufolini, Paola Dazzan, Robin M. Murray, Woo-Sung Kim, Young-Chul Chung, Christina Andreou, Andre Schmidt, Stefan Borgwardt, Andrew M. McIntosh, Heather C. Whalley, Stephen M. Lawrie, Stefan Du Plessis, Hilmar K. Luckhoff, Freda Scheffler, Robin Emsley, Dominik Grotegerd, Rebekka Lencer, Udo Dannlowski, Jesse T. Edmond, Kelly Rootes-Murdy, Julia M. Stephen, Andrew R. Mayer, Linda A. Antonucci, Leonardo Fazio, Giulio Pergola, Alessandro Bertolino, Covadonga M. Diaz-Caneja, Joost Janssen, Noemi G. Lois, Celso Arango, Alexander S. Tomyshev, Irina Lebedeva, Simon Cervenkav, Carl M. Sellgrenv, Foivos Georgiadis, Matthias Kirschner, Stefan Kaiser, Tomas Hajek, Antonin Skoch, Filip Spaniel, Minah Kim, Yoo Bin Kwak, Sanghoon Oh, Jun Soo Kwon, Anthony James, Geor Bakker, Christian Knochel, Michael Stablein, Viola Oertel, Anne Uhlmann, Fleur M. Howells, Dan J. Stein, Henk S. Temmingh, Ana M. Diaz-Zuluaga, Julian A. Pineda-Zapata, Carlos Lopez-Jaramillo, Stephanie Homan, Ellen Ji, Werner Surbeck, Philipp Homan, Simon E. Fishera, Barbara Franke, David C. Glahn, Ruben C. Gur, Ryota Hashimoto, Neda Jahanshad, Eileen Luders, Sarah E. Medland, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Clyde Francks
Summary: Left-right asymmetry is an important feature of the healthy brain that may be altered in schizophrenia. This study used a large sample size and consistent methods to investigate structural brain asymmetries in schizophrenia, finding significant differences. These differences may reflect changes at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Editorial Material
Neurosciences
Thomas W. Weickert, Cynthia Shannon Weickert
NEUROPSYCHOPHARMACOLOGY
(2023)
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Psychiatry
Esra Cesur, Steffen Moritz, Ryan P. Balzan, Jakob Scheunemann, Tana Gabbert, Adrianna Aleksandrowicz, Rabea Fischer
Summary: This study aimed to investigate the role of multiple biases in a community sample using more socially engaging stimuli, and found that the jumping to conclusions (JTC), bias against disconfirmatory evidence (BADE), and liberal acceptance (LA) biases may contribute to delusional ideation and extend to social situations.
SCHIZOPHRENIA RESEARCH
(2023)