α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling

Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation

(2021) Yexian Yuan et al.   EMBO JOURNAL

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

(2021) Franziska R. Traube et al.   Nature Communications

Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation

(2020) Yexian Yuan et al.   EMBO JOURNAL

Of mice and men: Murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

(2020) Sara Straniero et al.   JOURNAL OF LIPID RESEARCH

Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8

(2020) Xu Zha et al.   Aging-US

Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

(2020) Nadezda Apostolova et al.   Redox Biology

Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease

(2020) Julio M. Martinez-Moreno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNMT3B deficiency alters mitochondrial biogenesis and α-ketoglutarate levels in human embryonic stem cells

(2020) Artur Cieslar-Pobuda et al.   STEM CELLS

The role of α-ketoglutarate and the hypoxia sensing pathway in the regulation of pancreatic β-cell function

(2020) M. Hoang et al.   Islets

Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover

(2019) Wi S. Lai et al.   METHODS

α-Ketoglutarate inhibits autophagy

(2019) Elisa Elena Baracco et al.   Aging-US

Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats

(2019) Carmen D Tekwe et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

Alpha-ketoglutarate affects murine embryo development through metabolic and epigenetic modulations

(2019) Zhenzhen Zhang et al.   REPRODUCTION

Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

(2019) Qiyu Tian et al.   AGING CELL

The role and prospect of JMJD3 in stem cells and cancer

(2019) Xiaojiao Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

The interplay between m6A RNA methylation and noncoding RNA in cancer

(2019) Shuai Ma et al.   Journal of Hematology & Oncology

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

(2019) Tushar D Bhagat et al.   eLife

α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway

(2018) Xingcai Cai et al.   FASEB JOURNAL

Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA

(2018) Xue Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid β-oxidation

(2018) Sunmi Seok et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 1 diabetes

(2018) Richard Barnett   LANCET

Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis

(2018) Ying-Ying Lee et al.   NUCLEIC ACIDS RESEARCH

Prevention of Oxidative Stress by α-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro

(2018) Liuqin He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine

(2018) Paul Zimmet et al.   Nature Reviews Endocrinology

Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor

(2018) Claudio Coddou et al.   NEUROSCIENCE LETTERS

Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease

(2017) Syamantak Majumder et al.   JOURNAL OF CLINICAL INVESTIGATION

A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase

(2017) Mary Barrosse-Antle et al.   PEDIATRIC DIABETES

Functional Properties of the Mitochondrial Carrier System

(2017) Eric B. Taylor   TRENDS IN CELL BIOLOGY

Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway

(2017) Liuqin He et al.   Oncotarget

Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3

(2017) Evan P. Taddeo et al.   Scientific Reports

Heparin Increases Food Intake through AgRP Neurons

(2017) Canjun Zhu et al.   Cell Reports

The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications

(2016) Dingfu Xiao et al.   AMINO ACIDS

Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use

(2016) Barbara Zdzisińska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cells

(2016) Jianjian Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Metabolic time-course response after resistance exercise: A metabolomics approach

(2016) Ricardo Berton et al.   JOURNAL OF SPORTS SCIENCES

Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells

(2015) Gao Huasong et al.   BRAIN RESEARCH

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy

(2014) Guillermo Mariño et al.   Autophagy

Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2013) Sayuri Tsujimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

(2012) D. Glick et al.   MOLECULAR AND CELLULAR BIOLOGY

Serpin Peptidase Inhibitor Clade A Member 1 (SerpinA1) Is a Novel Biomarker for Progression of Cutaneous Squamous Cell Carcinoma

(2011) Mehdi Farshchian et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus

(2011) Qing Zhang et al.   JOURNAL OF AUTOIMMUNITY

Succinate Receptors in the Kidney

(2011) P. M. T. Deen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Triggering and amplification of insulin secretion by dimethyl α-ketoglutarate, a membrane permeable α-ketoglutarate analogue

(2009) Michael Willenborg et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transcriptome analysis by strand-specific sequencing of complementary DNA

(2009) Dmitri Parkhomchuk et al.   NUCLEIC ACIDS RESEARCH