Genetics-directed drug discovery for combating Mycobacterium tuberculosis infection

Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)

(2015) Kostas Kakleas et al.   AUTOIMMUNITY REVIEWS

The use of covalently immobilized stem cell factor to selectively affect hematopoietic stem cell activity within a gelatin hydrogel

(2015) Bhushan P. Mahadik et al.   BIOMATERIALS

Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe

(2015) Qingfei Zheng et al.   CHEMISTRY & BIOLOGY

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(2015)   CLINICAL PHARMACOLOGY & THERAPEUTICS

Complement mediators: key regulators of airway tissue remodeling in asthma

(2015) Mohammad Afzal Khan et al.   Journal of Translational Medicine

Serum interleukin 6 (IL-6) as a potential biomarker of disease progression in active pulmonary tuberculosis following anti-tuberculosis drug therapy

(2015) I.H. Chowdhury et al.   MOLECULAR IMMUNOLOGY

Host-directed drug therapy for tuberculosis

(2015) Reto Guler et al.   Nature Chemical Biology

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Exploring the potential of adjunct therapy in tuberculosis

(2015) Geetha Vani Rayasam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea

(2014) Serej D Ley et al.   BMC MICROBIOLOGY

Elucidating Polypharmacological Mechanisms of Polyphenols by Gene Module Profile Analysis

(2014) Bin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elucidating Pharmacological Mechanisms of Natural Medicines by Biclustering Analysis of the Gene Expression Profile: A Case Study on Curcumin and Si-Wu-Tang

(2014) Yuan Quan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human genetics of tuberculosis: a long and winding road

(2014) L. Abel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

HGV&TB: a comprehensive online resource on human genes and genetic variants associated with tuberculosis

(2014) R. Sahajpal et al.   Database-The Journal of Biological Databases and Curation

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Identification of transcription factors for drug-associated gene modules and biomedical implications

(2013) Min Xiong et al.   BIOINFORMATICS

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

ALOX5 Is Associated with Tuberculosis in a Subset of the Pediatric Population of North China

(2013) Chen Shen et al.   Genetic Testing and Molecular Biomarkers

The Mycobacterium tuberculosis regulatory network and hypoxia

(2013) James E. Galagan et al.   NATURE

Rational drug repositioning by medical genetics

(2013) Zhong-Yi Wang et al.   NATURE BIOTECHNOLOGY

DGIdb: mining the druggable genome

(2013) Malachi Griffith et al.   NATURE METHODS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

STITCH 4: integration of protein–chemical interactions with user data

(2013) Michael Kuhn et al.   NUCLEIC ACIDS RESEARCH

Medical genetic inspirations for anticancer drug repurposing

(2013) Zhong-Yi Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Calcineurin subunit B upregulates β-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4

(2011) Xinyu Wang et al.   CANCER SCIENCE

Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis

(2011) Ruth J. Napier et al.   Cell Host & Microbe

Tag SNP Polymorphism of CCL2 and Its Role in Clinical Tuberculosis in Han Chinese Pediatric Population

(2011) Wei-Xing Feng et al.   PLoS One

Can medical genetics and evolutionary biology inspire drug target identification?

(2011) Zhong-Yi Wang et al.   TRENDS IN MOLECULAR MEDICINE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH