Human NK cells activated by EBV+lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells

All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity

(2014) Diego Sanchez-Martínez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

(2013) C. J. Vandenberg et al.   BLOOD

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

Liposomes Decorated with Apo2L/TRAIL Overcome Chemoresistance of Human Hematologic Tumor Cells

(2013) Diego De Miguel et al.   MOLECULAR PHARMACEUTICS

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation

(2013) S E Lindner et al.   ONCOGENE

Recombinant production of human ICAM-1 chimeras by single step on column refolding and purification

(2013) David Núñez et al.   PROCESS BIOCHEMISTRY

Bringing natural killer cells to the clinic: ex vivo manipulation

(2013) R. W. Childs et al.   Hematology-American Society of Hematology Education Program

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells

(2013) Franco Locatelli et al.   Frontiers in Immunology

Natural killer cell alloreactivity 10 years later

(2012) Andrea Velardi   CURRENT OPINION IN HEMATOLOGY

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

(2012) S. P. Glaser et al.   GENES & DEVELOPMENT

From tumor cell metabolism to tumor immune escape

(2012) Martin Villalba et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Primary B-CLL Resistance to NK Cell Cytotoxicity can be Overcome In Vitro and In Vivo by Priming NK Cells and Monoclonal Antibody Therapy

(2012) Caroline Veuillen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

(2012) Cecele J. Denman et al.   PLoS One

Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients

(2011) A. Curti et al.   BLOOD

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Donor KIR haplotype B improves progression-free and overall survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma

(2011) N Kröger et al.   LEUKEMIA

NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia

(2010) Jeffrey E. Rubnitz et al.   JOURNAL OF CLINICAL ONCOLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

HLA-Haploidentical Stem Cell Transplantation for Hematologic Malignancies

(2009) Ephraim J. Fuchs et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy

(2009) H. Fujisaki et al.   CANCER RESEARCH

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

Clinical-grade ex vivo-expanded human natural killer cells up-regulate activating receptors and death receptor ligands and have enhanced cytolytic activity against tumor cells

(2009) Maria Berg et al.   CYTOTHERAPY

Expansion and Activation of Natural Killer Cells for Cancer Immunotherapy

(2009) Duck Cho et al.   Korean Journal of Laboratory Medicine

KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia

(2009) R Willemze et al.   LEUKEMIA

Infusion of haplo-identical killer immunoglobulin-like receptor ligand mismatched NK cells for relapsed myeloma in the setting of autologous stem cell transplantation

(2008) Jumei Shi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

(2008) K A Sedelies et al.   CELL DEATH AND DIFFERENTIATION

Can NK cells be a therapeutic target in human diseases?

(2008) Christopher J. Chan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

(2008) Mads Gyrd-Hansen et al.   NATURE CELL BIOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD