Identification of novel small molecules targeting core clock proteins to regulate circadian rhythm

Circadian Mechanisms in Medicine

(2021) Ravi Allada et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deep Learning in Virtual Screening: Recent Applications and Developments

(2021) Talia B. Kimber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Applications of Virtual Screening in Bioprospecting: Facts, Shifts, and Perspectives to Explore the Chemo-Structural Diversity of Natural Products

(2021) Kauê Santana et al.   Frontiers in Chemistry

A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude

(2020) Yagmur Umay Doruk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

(2020) Jennifer L Fribourgh et al.   eLife

CRY1‐CBS binding regulates circadian clock function and metabolism

(2020) Sibel Cal‐Kayitmazbatir et al.   FEBS Journal

Isoform-selective regulation of mammalian cryptochromes

(2020) Simon Miller et al.   Nature Chemical Biology

Coupled network of the circadian clocks: a driving force of rhythmic physiology

(2020) Anna‐Marie Finger et al.   FEBS LETTERS

Human CRY1 variants associate with attention deficit/hyperactivity disorder

(2020) O. Emre Onat et al.   JOURNAL OF CLINICAL INVESTIGATION

The Arg293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm

(2020) Seref Gul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

(2019) Ben J. Greenwell et al.   Cell Reports

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

(2018) Clark Rosensweig et al.   Nature Communications

Periodicity, repression, and the molecular architecture of the mammalian circadian clock

(2018) Clark Rosensweig et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Photolyase/Cryptochrome Family of Proteins as DNA Repair Enzymes and Transcriptional Repressors

(2017) Ibrahim Halil Kavakli et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1

(2017) Alicia K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

The Circadian Clock and Human Health

(2016) Till Roenneberg et al.   CURRENT BIOLOGY

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Milp-hyperbox classification for structure-based drug design in the discovery of small molecule inhibitors of SIRTUIN6

(2016) Mehmet Tardu et al.   RAIRO-OPERATIONS RESEARCH

Discovery of Novel CYP17 Inhibitors for the Treatment of Prostate Cancer with Structure-Based Drug Design

(2016) Pelin Armutlu et al.   Letters in Drug Design & Discovery

CH Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

(2015) Tsuyoshi Oshima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

(2015) Gad Asher et al.   CELL

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification and Validation of Cryptochrome Inhibitors That Modulate the Molecular Circadian Clock

(2014) Sung Kook Chun et al.   ACS Chemical Biology

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

(2014) Yaarit Adamovich et al.   Cell Metabolism

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

(2014) C De Mei et al.   ONCOGENE

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel BHLHE41 Variant is Associated with Short Sleep and Resistance to Sleep Deprivation in Humans

(2014) Renata Pellegrino et al.   SLEEP

Machine Learning Helps Identify CHRONO as a Circadian Clock Component

(2014) Ron C. Anafi et al.   PLOS BIOLOGY

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Optimized Chemical Probes for REV-ERBα

(2013) Ryan P. Trump et al.   JOURNAL OF MEDICINAL CHEMISTRY

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

(2013) D. Mauvoisin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Oscillations of Protein-Coding and Regulatory RNAs in a Highly Dynamic Mammalian Liver Epigenome

(2012) Christopher Vollmers et al.   Cell Metabolism

Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function

(2012) Sanjoy K. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Circadian Clocks in Mood Disorders

(2012) Michael J. McCarthy et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

(2012) Bilal Çakir et al.   PLoS One

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

(2011) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα

(2010) Daniel Grant et al.   ACS Chemical Biology

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

(2010) Douglas Kojetin et al.   ACS Chemical Biology

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

(2010) Naresh Kumar et al.   ACS Chemical Biology

Identification of two Amino Acids in the C-terminal Domain of Mouse CRY2 Essential for PER2 Interaction

(2010) Natali Ozber et al.   BMC MOLECULAR BIOLOGY

Recent Advances in Ligand-Based Drug Design: Relevance and Utility of the Conformationally Sampled Pharmacophore Approach

(2010) Chayan Acharya et al.   Current Computer-Aided Drug Design

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

(2010) Virginia Soria et al.   NEUROPSYCHOPHARMACOLOGY

Clock genes and body composition in patients with schizophrenia under treatment with antipsychotic drugs

(2010) Tim Moons et al.   SCHIZOPHRENIA RESEARCH

Identification of RACK1 and Protein Kinase C  as Integral Components of the Mammalian Circadian Clock

(2010) M. S. Robles et al.   SCIENCE

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

(2010) Tsuyoshi Hirota et al.   PLOS BIOLOGY

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

(2009) Y. He et al.   SCIENCE

Classification of drug molecules considering their IC50 values using mixed-integer linear programming based hyper-boxes method

(2008) Pelin Armutlu et al.   BMC BIOINFORMATICS

A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder

(2008) Francesco Benedetti et al.   NEUROSCIENCE LETTERS