Periodicity, repression, and the molecular architecture of the mammalian circadian clock

TwoCk1δtranscripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock

(2018) Jean-Michel Fustin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

(2018) Rajesh Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

(2018) Clark Rosensweig et al.   Nature Communications

Macromolecular Assemblies of the Mammalian Circadian Clock

(2017) Rajindra P. Aryal et al.   MOLECULAR CELL

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

(2017) Yuta Shinohara et al.   MOLECULAR CELL

A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms

(2017) Chelsea L. Gustafson et al.   MOLECULAR CELL

Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1

(2017) Koji L. Ode et al.   MOLECULAR CELL

The Photolyase/Cryptochrome Family of Proteins as DNA Repair Enzymes and Transcriptional Repressors

(2017) Ibrahim Halil Kavakli et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Vertebrate-like CRYPTOCHROME 2 from monarch regulates circadian transcription via independent repression of CLOCK and BMAL1 activity

(2017) Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1

(2017) Alicia K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor

(2017) Zhiqiang Hou et al.   STRUCTURE

The ratio of intracellular CRY proteins determines the clock period length

(2016) Yang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The genomic basis of circadian and circalunar timing adaptations in a midge

(2016) Tobias S. Kaiser et al.   NATURE

Pacemaker-neuron–dependent disturbance of the molecular clockwork by aDrosophilaCLOCK mutant homologous to the mouseClockmutation

(2016) Euna Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling

(2016) Mathew D. Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ube3a Imprinting Impairs Circadian Robustness in Angelman Syndrome Models

(2015) Shu-qun Shi et al.   CURRENT BIOLOGY

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

Histone monoubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback

(2015) Alfred G Tamayo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

(2015) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Decoupling circadian clock protein turnover from circadian period determination

(2015) L. F. Larrondo et al.   SCIENCE

Histone monoubiquitination by Clock–Bmal1 complex marks Per1 and Per2 genes for circadian feedback

(2015) Alfred G Tamayo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

(2015) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emerging Models for the Molecular Basis of Mammalian Circadian Timing

(2014) Chelsea L. Gustafson et al.   BIOCHEMISTRY

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

CLOCK:BMAL1 is a pioneer-like transcription factor

(2014) J. S. Menet et al.   GENES & DEVELOPMENT

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

(2014) Rui Ye et al.   GENES & DEVELOPMENT

Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression

(2014) Yunus Annayev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of the circadian clock protein PERIOD2 in living cells

(2014) R. Ollinger et al.   JOURNAL OF CELL SCIENCE

Specificity in Circadian Clock Feedback from Targeted Reconstitution of the NuRD Corepressor

(2014) Jin Young Kim et al.   MOLECULAR CELL

Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting

(2014) Hye Jin Nam et al.   MOLECULAR CELL

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

(2014) Hao A Duong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

A Positive Role for PERIOD in Mammalian Circadian Gene Expression

(2014) Makoto Akashi et al.   Cell Reports

Machine Learning Helps Identify CHRONO as a Circadian Clock Component

(2014) Ron C. Anafi et al.   PLOS BIOLOGY

A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock

(2014) Akihiro Goriki et al.   PLOS BIOLOGY

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

(2014) Shannon N Nangle et al.   eLife

Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function

(2013) Anna Czarna et al.   CELL

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase

(2013) Shannon Nangle et al.   CELL RESEARCH

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

(2013) Peng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

Cycles in spatial and temporal chromosomal organization driven by the circadian clock

(2013) Lorena Aguilar-Arnal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery

(2013) L. Lande-Diner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA

(2012) Zixi Wang et al.   CELL RESEARCH

Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function

(2012) Sanjoy K. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

(2012) Markus Stratmann et al.   MOLECULAR CELL

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

The Molecular Clockwork of the Fire Ant Solenopsis invicta

(2012) Krista K. Ingram et al.   PLoS One

Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

(2012) N. Kucera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKC  participates in food entrainment by regulating BMAL1

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex

(2012) K. Padmanabhan et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

(2011) Inês Chaves et al.   Annual Review of Plant Biology

Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function

(2011) Maki Ukai-Tadenuma et al.   CELL

A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation

(2011) Mary L. Spengler et al.   CELL CYCLE

Quantitative Analyses of Cryptochrome-mBMAL1 Interactions

(2011) Anna Czarna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock

(2011) Rui Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of full-length Drosophila cryptochrome

(2011) Brian D. Zoltowski et al.   NATURE

Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock

(2011) L. DiTacchio et al.   SCIENCE

A Molecular Mechanism for Circadian Clock Negative Feedback

(2011) H. A. Duong et al.   SCIENCE

Identification of two Amino Acids in the C-terminal Domain of Mouse CRY2 Essential for PER2 Interaction

(2010) Natali Ozber et al.   BMC MOLECULAR BIOLOGY

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

(2010) Sayako Katada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

(2010) Saurabh Sahar et al.   PLoS One

Identification of RACK1 and Protein Kinase C  as Integral Components of the Mammalian Circadian Clock

(2010) M. S. Robles et al.   SCIENCE

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Generation of a Novel Allelic Series of Cryptochrome Mutants via Mutagenesis Reveals Residues Involved in Protein-Protein Interaction and CRY2-Specific Repression

(2009) E. V. McCarthy et al.   MOLECULAR AND CELLULAR BIOLOGY

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

(2009) H. Yoshitane et al.   MOLECULAR AND CELLULAR BIOLOGY

Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism

(2009) Rongmin Chen et al.   MOLECULAR CELL

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2

(2009) Sven Hennig et al.   PLOS BIOLOGY

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

(2008) Andrew C. Liu et al.   PLoS Genetics