Dietary Restriction and Rapamycin Affect Brain Aging in Mice by Attenuating Age-Related DNA Methylation Changes

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

(2020) Noémie Gensous et al.   Nutrients

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

(2020) Dae Hyun Kim et al.   Nutrients

Rapamycin rejuvenates oral health in aging mice

(2020) Jonathan Y An et al.   eLife

Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities

(2020) Fedor Galkin et al.   AGEING RESEARCH REVIEWS

Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family

(2020) Jose Vladimir Sandoval-Sierra et al.   AGING CELL

Is Rapamycin a Dietary Restriction Mimetic?

(2019) Archana Unnikrishnan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Maternal circadian disruption is associated with variation in placental DNA methylation

(2019) Danielle A. Clarkson-Townsend et al.   PLoS One

Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila

(2019) Joseph M. Schinaman et al.   Scientific Reports

Rapamycin protects aging muscle

(2019) Huibin Tang et al.   Aging-US

Rapamycin for longevity: opinion article

(2019) Mikhail V. Blagosklonny   Aging-US

Multi-omics approaches to human biological age estimation

(2019) Ilya Solovev et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Revisiting the genomic hypomethylation hypothesis of aging

(2018) Archana Unnikrishnan et al.   Annals of the New York Academy of Sciences

Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription

(2018) Carl Baribault et al.   Epigenetics

DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function

(2018) Di Cui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

(2018) Martin Widschwendter et al.   Nature Reviews Clinical Oncology

GOATOOLS: A Python library for Gene Ontology analyses

(2018) D. V. Klopfenstein et al.   Scientific Reports

Gene Expression and Methylation Analysis of ABCA7 in Patients with Alzheimer’s Disease

(2017) Kiyohiro Yamazaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Beneficial effects of dietary restriction in aging brain

(2017) Ibanylla Kynjai Hynniewta Hadem et al.   JOURNAL OF CHEMICAL NEUROANATOMY

DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

(2017) Yuki Ozaki et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Identifying CpG sites with different differential methylation frequencies in colorectal cancer tissues based on individualized differential methylation analysis

(2017) Haidan Yan et al.   Oncotarget

DNA Methylation of Synaptic Genes in the Prefrontal Cortex Is Associated with Aging and Age-Related Cognitive Impairment

(2017) Lara Ianov et al.   Frontiers in Aging Neuroscience

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

(2017) Sabine Langie et al.   Genes

Systems-level analysis of human aging genes shed new light on mechanisms of aging

(2016) Quanwei Zhang et al.   HUMAN MOLECULAR GENETICS

Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer’s Disease Subjects

(2016) Yuta Yoshino et al.   JOURNAL OF ALZHEIMERS DISEASE

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

(2016) Carla Garza-Lombó et al.   Frontiers in Cellular Neuroscience

Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice

(2016) Niran Hadad et al.   Epigenetics & Chromatin

Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex

(2016) Lara Ianov et al.   Frontiers in Aging Neuroscience

Aging and DNA methylation

(2015) Marc Jung et al.   BMC BIOLOGY

Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms

(2015) Helen L Fisher et al.   Epigenetics

Competition between DNA methylation and transcription factors determines binding of NRF1

(2015) Silvia Domcke et al.   NATURE

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Concordant and discordant DNA methylation signatures of aging in human blood and brain

(2015) Pau Farré et al.   Epigenetics & Chromatin

Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain

(2015) Huan Gong et al.   Oncotarget

DNA methylation and cognitive aging

(2015) Xiangru Xu   Oncotarget

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

(2015) Eleni M. Tomazou et al.   Cell Reports

Genetics and epigenetics of aging and longevity

(2014) Alexey Moskalev et al.   CELL CYCLE

Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension

(2014) Jeffrey van Haren et al.   CURRENT BIOLOGY

Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing

(2014) Hong Qian et al.   EXPERIMENTAL DERMATOLOGY

Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver

(2014) Zhen Yu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epigenetic Variation in Monozygotic Twins: A Genome-Wide Analysis of DNA Methylation in Buccal Cells

(2014) Jenny van Dongen et al.   Genes

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(2013) Wilson C. Fok et al.   AGING CELL

BS-Seeker2: a versatile aligning pipeline for bisulfite sequencing data

(2013) Weilong Guo et al.   BMC GENOMICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The role of AUTS2 in neurodevelopment and human evolution

(2013) Nir Oksenberg et al.   TRENDS IN GENETICS

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Effects of dietary fish oil on learning function and apoptosis of hippocampal pyramidal neurons in streptozotocin-diabetic rats

(2012) Chang-Hai Zhao et al.   BRAIN RESEARCH

Role of L1CAM for axon sprouting and branching

(2012) Michael K. E. Schäfer et al.   CELL AND TISSUE RESEARCH

Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice

(2012) Wilson C. Fok et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

DNA methylation in cognition comes of age

(2012) Susan C Su et al.   NATURE NEUROSCIENCE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic regulation of caloric restriction in aging

(2011) Yuanyuan Li et al.   BMC Medicine

DNA-binding factors shape the mouse methylome at distal regulatory regions

(2011) Michael B. Stadler et al.   NATURE

Cell adhesion molecules in the central nervous system

(2010) Hideru Togashi et al.   Cell Adhesion & Migration

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

A midlife longevity drug?

(2009) Matt Kaeberlein et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE