Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm

Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?

(2021) Anna Kovalchuk et al.   Aging-US

Elucidation of the Mechanism of Action of Ginseng Against Acute Lung Injury/Acute Respiratory Distress Syndrome by a Network Pharmacology-Based Strategy

(2021) Qi Ding et al.   Frontiers in Pharmacology

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

(2021) Keivan Zandi et al.   Microorganisms

Virtual screening of plant-derived compounds against SARS-CoV-2 viral proteins using computational tools

(2021) María Antonela Zígolo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

SARS-CoV-2 B.1.617.2 (Delta) Variant COVID-19 Outbreak Associated with a Gymnastics Facility — Oklahoma, April–May 2021

(2021) Kendra Dougherty et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

(2020) Hussin A. Rothan et al.   JOURNAL OF AUTOIMMUNITY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Peroxiredoxin-1 aggravates lipopolysaccharide-induced septic shock via promoting inflammation

(2020) Ying He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

(2020) Shivraj Hariram Nile et al.   CYTOKINE & GROWTH FACTOR REVIEWS

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Molecular immune pathogenesis and diagnosis of COVID-19

(2020) Xiaowei Li et al.   Journal of Pharmaceutical Analysis

Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019

(2020) Zhe Zhu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

COVID-19 revisiting inflammatory pathways of arthritis

(2020) Georg Schett et al.   Nature Reviews Rheumatology

Immunological regulatory effect of flavonoid baicalin on innate immune toll-like receptors

(2020) Ming Jiang et al.   PHARMACOLOGICAL RESEARCH

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

(2020) Daniella S. Battagello et al.   CLINICAL SCIENCE

Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex

(2020) Aaron C. Petrey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

(2020) Luca Perico et al.   Nature Reviews Nephrology

Natural products for COVID ‐19 prevention and treatment regarding to previous coronavirus infections and novel studies

(2020) Motahareh Boozari et al.   PHYTOTHERAPY RESEARCH

Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study

(2020) Jing Gong et al.   BMC INFECTIOUS DISEASES

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biomimetic Nanoparticles Potentiate the Anti-Inflammatory Properties of Dexamethasone and Reduce the Cytokine Storm Syndrome: An Additional Weapon against COVID-19?

(2020) Roberto Molinaro et al.   Nanomaterials

A Molecular Docking Approach to Evaluate the Pharmacological Properties of Natural and Synthetic Treatment Candidates for Use against Hypertension

(2019) Syed Attique et al.   International Journal of Environmental Research and Public Health

Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells

(2019) Ji Yang et al.   Cell Death & Disease

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

(2019) Li-Ting Guo et al.   Journal of Neuroinflammation

Suppressive effects of sunitinib on a TLR activation-induced cytokine storm

(2019) Sheng Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway

(2019) Xiangli Meng et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

VEGF and FGF-2: Promising targets for the treatment of respiratory disorders

(2019) Ankit P. Laddha et al.   RESPIRATORY MEDICINE

MicroRNA-124 alleviates the lung injury in mice with septic shock through inhibiting the activation of the MAPK signaling pathway by downregulating MAPK14

(2019) Weiyun Pan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MiR-424 overexpression protects alveolar epithelial cells from LPS-induced apoptosis and inflammation by targeting FGF2 via the NF-κB pathway

(2019) Dongliang Cheng et al.   LIFE SCIENCES

MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile

(2018) Waleed H. Mahallawi et al.   CYTOKINE

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis

(2018) Peng Pang et al.   Evidence-based Complementary and Alternative Medicine

Pathophysiological Roles of Intracellular Proteases in Neuronal Development and Neurological Diseases

(2018) Tatsurou Yagami et al.   MOLECULAR NEUROBIOLOGY

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

(2017) Biswanath Dinda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

IL-17 Signaling: The Yin and the Yang

(2017) Nilesh Amatya et al.   TRENDS IN IMMUNOLOGY

EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer

(2017) Xiaoping Wang et al.   Oncotarget

Cyclooxygenase 2: its regulation, role and impact in airway inflammation

(2016) N. N. Rumzhum et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interleukin-17A Is Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome

(2016) Carmen Mikacenic et al.   CRITICAL CARE MEDICINE

Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

(2016) Shuangquan Yan et al.   Evidence-based Complementary and Alternative Medicine

Getting the most out of PubChem for virtual screening

(2016) Sunghwan Kim   Expert Opinion on Drug Discovery

Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype

(2016) Wei Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice

(2016) XIN-MIN DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Scutellaria baicalensis , the golden herb from the garden of Chinese medicinal plants

(2016) Qing Zhao et al.   Science Bulletin

CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks

(2015) Yu Tang et al.   BIOSYSTEMS

Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza

(2015) Grant S. Schulert et al.   JOURNAL OF INFECTIOUS DISEASES

Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase

(2014) Yue Ding et al.   ARCHIVES OF VIROLOGY

Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses

(2014) M. K. Nayak et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effective identification of essential proteins based on priori knowledge, network topology and gene expressions

(2014) Min Li et al.   METHODS

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

(2014) David Gfeller et al.   NUCLEIC ACIDS RESEARCH

Tumor necrosis factor alpha in mycobacterial infection

(2014) Anca Dorhoi et al.   SEMINARS IN IMMUNOLOGY

Importance of reverse signaling of the TNF superfamily in immune regulation

(2013) Kata Juhász et al.   Expert Review of Clinical Immunology

Tumor necrosis factor

(2012) Wen-Ming Chu   CANCER LETTERS

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY