Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells

Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

(2017) Shanshan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

T follicular regulatory cells in mice and men

(2017) Ana Raquel Maceiras et al.   IMMUNOLOGY

Bone marrow-derived mesenchymal stem cells inhibit T follicular helper cell in lupus-prone mice

(2017) X Yang et al.   LUPUS

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

(2017) Woelsung Yi et al.   Nature Communications

Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients

(2017) Satoshi Kubo et al.   Arthritis & Rheumatology

T Follicular Helper Cells As a New Target for Immunosuppressive Therapies

(2017) Lin Yan et al.   Frontiers in Immunology

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis

(2016) Patrick Blanco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Block of both TGF-β and IL-2 signaling impedes Neurophilin-1+ regulatory T cell and follicular regulatory T cell development

(2016) Liang Li et al.   Cell Death & Disease

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

(2016) Meryem Aloulou et al.   Nature Communications

Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses

(2016) Jialong Yang et al.   eLife

Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity

(2015) Wen-xia Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Signs of impaired immunoregulation and enhanced effector T-cell responses in the primary antiphospholipid syndrome

(2015) B Jakiela et al.   LUPUS

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

Bcl-6 controlled TFH polarization and memory: the known unknowns

(2014) Hai Qi et al.   CURRENT OPINION IN IMMUNOLOGY

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

(2014) Pramod Aryal et al.   FEBS Journal

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

(2014) Martin Vaeth et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients

(2014) Li Wang et al.   Journal of Translational Medicine

T Follicular Helper Cells and Regulatory B Cells Dynamics in Systemic Lupus Erythematosus

(2014) Xue Yang et al.   PLoS One

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice

(2013) Xue Yang et al.   PLoS One

Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease

(2012) Takashi Maehara et al.   ANNALS OF THE RHEUMATIC DISEASES

Germinal Center B-cells

(2012) Keith M. Hamel et al.   AUTOIMMUNITY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Baicalin as an Immunoregulatory Compound by Controlling TH17 Cell Differentiation

(2011) Ji Yang et al.   PLoS One

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses

(2008) Cecile King et al.   Annual Review of Immunology

Protective effect of baicalin against Lipopolysaccharide/d-galactosamine-induced liver injury in mice by up-regulation of Heme oxygenase-1

(2008) Jing-Yuan Wan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY