Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases

Ergothioneine, recent developments

(2021) Irwin K. CHEAH et al.   Redox Biology

The current status of biotechnological production and the application of a novel antioxidant ergothioneine

(2021) Yiwen Han et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Mushroom-Derived Medicine? Preclinical Studies Suggest Potential Benefits of Ergothioneine for Cardiometabolic Health

(2021) Daniel Lam-Sidun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

On the Identification and Quantification of Ergothioneine and Lovastatin in Various Mushroom Species: Assets and Challenges of Different Analytical Approaches

(2021) Konstantinos Tsiantas et al.   MOLECULES

Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota

(2021) Wen-Long Sun et al.   Cell Reports

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

The biology of ergothioneine, an antioxidant nutraceutical

(2020) Irina Borodina et al.   NUTRITION RESEARCH REVIEWS

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

(2020) Irwin K. Cheah et al.   Antioxidants

Modulation of the Microbiome in Parkinson’s Disease: Diet, Drug, Stool Transplant, and Beyond

(2020) Ethan G. Brown et al.   Neurotherapeutics

Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn’s Disease

(2019) Yunjia Lai et al.   MOLECULES

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

(2019) Lei Feng et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of low molecular weight thiols in Mycobacterium tuberculosis

(2019) C. Sao Emani et al.   TUBERCULOSIS

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

(2019) Einar Smith et al.   HEART

L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model

(2019) Rachel D. Williamson et al.   HYPERTENSION

Bidirectional interactions between dietary curcumin and gut microbiota

(2018) Liang Shen et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Substrate Selectivity Check of the Ergothioneine Transporter

(2018) Julia Tschirka et al.   DRUG METABOLISM AND DISPOSITION

The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection

(2018) Akshamal M. Gamage et al.   FASEB JOURNAL

Ergothioneine - a diet-derived antioxidant with therapeutic potential

(2018) Barry Halliwell et al.   FEBS LETTERS

Anti-inflammatory properties of edible mushrooms: A review

(2018) Bożena Muszyńska et al.   FOOD CHEMISTRY

The potential therapeutic effects of ergothioneine in pre-eclampsia

(2018) Robert N. Kerley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interplay between ROS and Antioxidants during Ischemia-Reperfusion Injuries in Cardiac and Skeletal Muscle

(2018) Tingyang Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues

(2018) Richard Ming Yi Tang et al.   Scientific Reports

Mushrooms: A rich source of the antioxidants ergothioneine and glutathione

(2017) Michael D. Kalaras et al.   FOOD CHEMISTRY

Ergothioneine products derived by superoxide oxidation in endothelial cells exposed to high-glucose

(2017) Luigi Servillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ergothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity

(2017) Christopher Stoffels et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Overview of Culinary and Medicinal Mushrooms in Neurodegeneration and Neurotrauma Research

(2017) Kah-Hui Wong et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Alzheimer’s Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome State

(2017) Liang Shen et al.   JOURNAL OF ALZHEIMERS DISEASE

Ergothioneine Antioxidant Function

(2017) Luigi Servillo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal-Induced Injuries in Rat Pheochromocytoma Cells

(2017) Tuzz-Ying Song et al.   Oxidative Medicine and Cellular Longevity

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

(2016) Irwin K. Cheah et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis

(2016) Barry Halliwell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial [dys]function; culprit in pre-eclampsia?

(2016) C. M. McCarthy et al.   CLINICAL SCIENCE

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

(2016) Nunzia D’Onofrio et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Safety Evaluation of a Nature-Identical l-Ergothioneine in Sprague Dawley Rats

(2016) Palma Ann Marone et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Oxidative-stress detoxification and signalling in cyanobacteria: the crucial glutathione synthesis pathway supports the production of ergothioneine and ophthalmate

(2016) Kinsley Narainsamy et al.   MOLECULAR MICROBIOLOGY

Anti-obesogenic and antidiabetic effects of plants and mushrooms

(2016) Jan Martel et al.   Nature Reviews Endocrinology

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms)

(2016) Mona S. Calvo et al.   PLANT FOODS FOR HUMAN NUTRITION

Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice

(2016) Noritaka Nakamichi et al.   Brain and Behavior

A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation

(2015) Takashi Asahi et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice

(2015) Takuya Shimizu et al.   Drug Metabolism and Pharmacokinetics

Reproductive safety evaluation of L-Ergothioneine

(2015) Roy Forster et al.   FOOD AND CHEMICAL TOXICOLOGY

Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels

(2015) Carolin Pfeiffer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence?

(2015) Irwin K. Cheah et al.   FREE RADICAL RESEARCH

Elimination of Ascorbic Acid After High-Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation

(2014) Torben K. Nielsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Bioinformatic and Biochemical Characterizations of C–S Bond Formation and Cleavage Enzymes in the Fungus Neurospora crassa Ergothioneine Biosynthetic Pathway

(2014) Wen Hu et al.   ORGANIC LETTERS

Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults

(2014) Salvatore Sotgia et al.   PLoS One

Ergothioneine Is a Secreted Antioxidant in Mycobacterium smegmatis

(2013) Carine Sao Emani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1

(2013) M. Albiero et al.   DIABETES

Ergothioneine protects against neuronal injury induced by β-amyloid in mice

(2012) Nae-Cherng Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparative Study of Contents of Several Bioactive Components in Fruiting Bodies and Mycelia of Culinary-Medicinal Mushrooms

(2012) Yu-Chang Lo et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Contents of lovastatin, γ-aminobutyric acid and ergothioneine in mushroom fruiting bodies and mycelia

(2012) Shin-Yu Chen et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Ergothioneine; antioxidant potential, physiological function and role in disease

(2011) Irwin K. Cheah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cyanobacteria produce high levels of ergothioneine

(2011) Carolin Pfeiffer et al.   FOOD CHEMISTRY

Ergothioneine as an Anti-Oxidative/Anti-Inflammatory Component in Several Edible Mushrooms

(2011) Tomomi ITO et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

The Effect of Ergothioneine on Clastogenic Potential and Mutagenic Activity

(2011) Alexander G. Schauss et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons

(2011) N. N. Jong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

The ergothioneine transporter controls and indicates ergothioneine activity — A review

(2011) Dirk Gründemann   PREVENTIVE MEDICINE

The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation

(2011) AuBrei J. Weigand-Heller et al.   PREVENTIVE MEDICINE

Ergothioneine Prevents Copper-Induced Oxidative Damage to DNA and Protein by Forming a Redox-Inactive Ergothioneine−Copper Complex

(2010) Ben-Zhan Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

(2010) T. Sugiura et al.   DRUG METABOLISM AND DISPOSITION

Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo

(2010) Tuzz-Ying Song et al.   FOOD AND CHEMICAL TOXICOLOGY

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

(2010) Yukio Kato et al.   PHARMACEUTICAL RESEARCH

Mushroom intolerance: a novel diet–gene interaction in Crohn's disease

(2009) Ivonne Petermann et al.   BRITISH JOURNAL OF NUTRITION

The unusual amino acid L-ergothioneine is a physiologic cytoprotectant

(2009) B D Paul et al.   CELL DEATH AND DIFFERENTIATION

Increased ergothioneine tissue concentrations in carriers of the Crohn's disease risk-associated 503F variant of the organic cation transporter OCTN1

(2009) D Taubert et al.   GUT

Functional Characterization of Ergothioneine Transport by Rat Organic Cation/Carnitine Transporter Octn1 (slc22a4)

(2008) Toshimichi Nakamura et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Expression patterns of the organic cation/carnitine transporter family in adult murine brain

(2007) Anne Marie Lamhonwah et al.   BRAIN & DEVELOPMENT

Ergothioneine Modulates Proinflammatory Cytokines and Heat Shock Protein 70 in Mesenteric Ischemia and Reperfusion Injury

(2007) Omer Sakrak et al.   JOURNAL OF SURGICAL RESEARCH