Effect of metal ions on Alzheimer's disease

Copper Imbalance in Alzheimer’s Disease: Meta-Analysis of Serum, Plasma, and Brain Specimens, and Replication Study Evaluating ATP7B Gene Variants

(2021) Rosanna Squitti et al.   Biomolecules

Associative Interactions among Zinc, Apolipoprotein E, and Amyloid-β in the Amyloid Pathology

(2020) Shin Bi Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ

(2020) Jie Huang et al.   NUCLEIC ACIDS RESEARCH

Zinc modulates synaptic transmission by differentially regulating synaptic glutamate homeostasis in hippocampus

(2020) Zhijun Shen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Reverse regulation of hepatic ceruloplasmin production in rat model of myocardial ischemia

(2020) Dan Yang et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

(2019) Andrew Tsatsanis et al.   NEUROCHEMICAL RESEARCH

Targeting the Iron-Response Elements of the mRNAs for the Alzheimer’s Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity

(2019) Jack Rogers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease

(2019) Anil R. Wadhwani et al.   ANNALS OF NEUROLOGY

Redox active metals in neurodegenerative diseases

(2019) Karla Acevedo et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Binding and Reactivity of Copper to R1 and R3 Fragments of tau Protein

(2019) Chiara Bacchella et al.   INORGANIC CHEMISTRY

The cost of Alzheimer's disease in China and re-estimation of costs worldwide

(2018) Jianping Jia et al.   Alzheimers & Dementia

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

(2018) Ya-Shuo Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases

(2018) Pamela Maher   FREE RADICAL BIOLOGY AND MEDICINE

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Dysregulation and Dislocation of SFPQ Disturbed DNA Organization in Alzheimer’s Disease and Frontotemporal Dementia

(2018) Jing Lu et al.   JOURNAL OF ALZHEIMERS DISEASE

Zinc Exacerbates Tau Pathology in a Tau Mouse Model

(2018) Kristen M. Craven et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer’s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery

(2018) Antonietta Vilella et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Mitoferrin-1 is Involved in the Progression of Alzheimer’s Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer’s Disease

(2018) Jiatao Huang et al.   NEUROSCIENCE

Free Copper Distinguishes Mild Cognitive Impairment Subjects from Healthy Elderly Individuals

(2018) Rosanna Squitti et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of K832R and R952K SNPs of Wilson's Disease Gene with Alzheimer's Disease

(2018) Serena Bucossi et al.   JOURNAL OF ALZHEIMERS DISEASE

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

(2018) Abdel A. Belaidi et al.   Neurotherapeutics

Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese

(2018) Katriana A. Popichak et al.   Journal of Neuroinflammation

Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1–42 and Enhances Aβ1–42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death

(2018) Tomoyuki Nishizaki   MOLECULAR NEUROBIOLOGY

Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways

(2017) Entaz Bahar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cortical Iron Reflects Severity of Alzheimer’s Disease

(2017) Sara van Duijn et al.   JOURNAL OF ALZHEIMERS DISEASE

The effect of postnatal manganese exposure on the NMDA receptor signaling pathway in rat hippocampus

(2017) Lei Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load

(2017) K Goozee et al.   MOLECULAR PSYCHIATRY

Mitochondrial Ferritin Deletion Exacerbatesβ-Amyloid-Induced Neurotoxicity in Mice

(2017) Peina Wang et al.   Oxidative Medicine and Cellular Longevity

Association of Serum Manganese Levels with  Alzheimer’s Disease and Mild Cognitive Impairment:  A Systematic Review and Meta‐Analysis

(2017) Ke Du et al.   Nutrients

Serum Copper, Zinc, and Iron Levels in Patients with Alzheimer's Disease: A Meta-Analysis of Case-Control Studies

(2017) Dan-Dan Li et al.   Frontiers in Aging Neuroscience

Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice

(2016) Lan-yan Lin et al.   Molecular Neurodegeneration

Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer’s Disease

(2016) Yingbo Fu et al.   MOLECULES

Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta

(2016) Masashi Kitazawa et al.   TOXICOLOGICAL SCIENCES

First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease

(2016) Timothy R. DeGrado et al.   Molecular Imaging

Transfer of Copper from an Amyloid to a Natural Copper-Carrier Peptide with a Specific Mediating Ligand

(2015) Michel Nguyen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper at synapse: Release, binding and modulation of neurotransmission

(2015) Nadia D'Ambrosi et al.   NEUROCHEMISTRY INTERNATIONAL

Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

(2014) Rosanna Squitti et al.   ANNALS OF NEUROLOGY

Manganese leads to an increase in markers of oxidative stress as well as to a shift in the ratio of Fe(ii)/(iii) in rat brain tissue

(2014) Katharina Fernsebner et al.   Metallomics

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease

(2014) Javier Becerril-Ortega et al.   NEUROBIOLOGY OF AGING

Cognitive function and plasma BDNF levels among manganese-exposed smelters

(2014) Yunfeng Zou et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Subneurotoxic copper(II)-induced NF-κB-dependent microglial activation is associated with mitochondrial ROS

(2014) Zhuqin Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Protective Effects of Riluzole on Manganese-Induced Disruption of Glutamate Transporters and Glutamine Synthetase in the Cultured Astrocytes

(2012) Yu Deng et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Synaptic Released Zinc Promotes Tau Hyperphosphorylation by Inhibition of Protein Phosphatase 2A (PP2A)

(2012) Xu-Ying Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Linkage Disequilibrium and Haplotype Analysis of the ATP7B Gene in Alzheimer's Disease

(2012) Rosanna Squitti et al.   REJUVENATION RESEARCH

Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients

(2011) Nicole L. Bjorklund et al.   JOURNAL OF NEUROSCIENCE METHODS

Expression and Localization of Mitochondrial Ferritin mRNA in Alzheimer's Disease Cerebral Cortex

(2011) Ligang Wang et al.   PLoS One

Oxidatively generated DNA damage after Cu(II) catalysis of dopamine and related catecholamine neurotransmitters and neurotoxins: Role of reactive oxygen species

(2010) Wendy A. Spencer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc Overload Enhances APP Cleavage and Aβ Deposition in the Alzheimer Mouse Brain

(2010) Chun-Yan Wang et al.   PLoS One

Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction

(2010) C Corona et al.   Cell Death & Disease

Manganese Homeostasis inSaccharomyces cerevisiae

(2009) Amit R. Reddi et al.   CHEMICAL REVIEWS

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS