NF-κB, a culprit of both inflamm-ageing and declining immunity?

Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions

(2021) Mano R. Maurya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

(2021) Hazel J. Shields et al.   Frontiers in Cell and Developmental Biology

NF-κB dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages

(2021) Quen J. Cheng et al.   SCIENCE

A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age

(2021) Rachel H McMahan et al.   Immunity & Ageing

Blood–Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia

(2021) Basharat Hussain et al.   Frontiers in Neuroscience

Commentary on Some Recent Theses Relevant to Combating Aging: December 2021

(2021) Benjamin Zealley   REJUVENATION RESEARCH

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Classical and Nonclassical Intercellular Communication in Senescence and Ageing

(2020) Juan Antonio Fafián-Labora et al.   TRENDS IN CELL BIOLOGY

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

(2019) Emiliano Trias et al.   Frontiers in Aging Neuroscience

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

(2019) Song Ho Chang et al.   Nature Communications

Short-term high-fat meal intake alters the expression of circadian clock-, inflammation-, and oxidative stress-related genes in human skeletal muscle

(2019) Zsófia Budai et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Exclusivity and Compensation in NFκB Dimer Distributions and IκB Inhibition

(2019) Kristen M. Ramsey et al.   BIOCHEMISTRY

Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism

(2019) Mara Mazzoni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

NF-κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

(2019) Edoardo Parrella et al.   Translational Neurodegeneration

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Assaying Homodimers of NF-κB in Live Single Cells

(2019) Erik W. Martin et al.   Frontiers in Immunology

Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot study

(2019) R.T. Mankowski et al.   EXPERIMENTAL GERONTOLOGY

Effects of 90 Days of Resveratrol Supplementation on Cognitive Function in Elders: A Pilot Study

(2018) Stephen D. Anton et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Properties and functions of adipose tissue macrophages in obesity

(2018) Lucia Russo et al.   IMMUNOLOGY

Senescence and senotherapeutics: a new field in cancer therapy

(2018) Vassilios Myrianthopoulos et al.   PHARMACOLOGY & THERAPEUTICS

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

(2018) Heather L. Thompson et al.   AGING CELL

Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice

(2018) Hee-Kyung Hong et al.   GENES & DEVELOPMENT

Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock

(2018) Frédéric Gachon et al.   GENES & DEVELOPMENT

F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus

(2017) Mahiro Egashira et al.   ENDOCRINOLOGY

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

(2017) Alicia S. Wellman et al.   GASTROENTEROLOGY

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidermal Dysfunction Leads to an Age-Associated Increase in Levels of Serum Inflammatory Cytokines

(2017) Lizhi Hu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs

(2017) John S Davies et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Intercellular communication for innate immunity

(2017) Tan A. Nguyen et al.   MOLECULAR IMMUNOLOGY

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

(2017) Jonathan D. Proto et al.   PLoS One

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

(2017) Annika Höhn et al.   Redox Biology

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice

(2016) Kyung-Ah Kim et al.   BMC MICROBIOLOGY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

Loss of Nfkb1 leads to early onset aging

(2016) Giovanna M. Bernal et al.   Aging-US

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

(2014) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

(2014) Julie Gibbs et al.   NATURE MEDICINE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

NF-κB: roles and regulation in different CD4+T-cell subsets

(2013) Hyunju Oh et al.   IMMUNOLOGICAL REVIEWS

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

(2012) Protásio L. da Luz et al.   ATHEROSCLEROSIS

Late-onset Parkinsonism in NF B/c-Rel-deficient mice

(2012) C. Baiguera et al.   BRAIN

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

A Key Role for NF-κB Transcription Factor c-Rel in T-Lymphocyte-Differentiation and Effector Functions

(2012) Alexander Visekruna et al.   Clinical & Developmental Immunology

Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia

(2012) Angela R. Boyd et al.   EXPERIMENTAL GERONTOLOGY

DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out

(2012) Kevin W. McCool et al.   IMMUNOLOGICAL REVIEWS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Core circadian protein CLOCK is a positive regulator of NF- B-mediated transcription

(2012) M. L. Spengler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary factors and low-grade inflammation in relation to overweight and obesity

(2011) Philip C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Advanced Age Impairs Macrophage Polarization

(2011) Shegufta Mahbub et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

(2011) Trevor Siggers et al.   NATURE IMMUNOLOGY

What do we mean when we write “senescence,”“apoptosis,”“necrosis,” or “clearance of dying cells”?

(2010) Dror Mevorach et al.   Annals of the New York Academy of Sciences

Role of NF-κB in the skeleton

(2010) Deborah Veis Novack   CELL RESEARCH

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

GFP-p65 knock-in mice as a tool to study NF-κB dynamics in vivo

(2009) Rossana De Lorenzi et al.   GENESIS

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL