Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation

Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI

(2016) Mushfiquddin Khan et al.   BRAIN RESEARCH

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor

(2015) Kazufumi Hirano et al.   ANTIOXIDANTS & REDOX SIGNALING

A subset of N-substituted phenothiazines inhibits NADPH oxidases

(2015) Tamara Seredenina et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypobromous acid, a powerful endogenous electrophile: Experimental and theoretical studies

(2015) Valdecir Farias Ximenes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

(2015) Yang Li et al.   ACS Medicinal Chemistry Letters

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

High-throughput Assays for Superoxide and Hydrogen Peroxide

(2014) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

(2013) Eugenia Cifuentes-Pagano et al.   ANTIOXIDANTS & REDOX SIGNALING

Reaction between Peroxynitrite and Triphenylphosphonium-Substituted Arylboronic Acid Isomers: Identification of Diagnostic Marker Products and Biological Implications

(2013) Adam Sikora et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Silicon-Heteroaromatic System as Photosensitizer for Light-Driven Hydrogen Production by Hydrogenase Mimics

(2013) Roman Goy et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation

(2013) Jacek Zielonka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitoxantrone Targets Human Ubiquitin-Specific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Cell Survival

(2013) Richard A. Burkhart et al.   MOLECULAR CANCER RESEARCH

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms

(2013) Balaraman Kalyanaraman   Redox Biology

Opportunity Nox: The Future of NADPH Oxidases as Therapeutic Targets in Cardiovascular Disease

(2012) Jennifer Streeter et al.   Cardiovascular Therapeutics

Targeting NOX enzymes in pulmonary fibrosis

(2012) Louise Hecker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting NADPH oxidases for the treatment of cancer and inflammation

(2012) Michael Y. Bonner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Boronate Probes as Diagnostic Tools for Real Time Monitoring of Peroxynitrite and Hydroperoxides

(2012) Jacek Zielonka et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Hydropropidine: A novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide

(2012) Radoslaw Michalski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Reaction between Peroxynitrite and Boronates: EPR Spin-Trapping, HPLC Analyses, and Quantum Mechanical Study of the Free Radical Pathway

(2011) Adam Sikora et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

(2011) Imad Al Ghouleh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global Profiling of Reactive Oxygen and Nitrogen Species in Biological Systems

(2011) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy

(2010) Y. Zhao et al.   CANCER RESEARCH

Peroxynitrite Is the Major Species Formed from Different Flux Ratios of Co-generated Nitric Oxide and Superoxide

(2010) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Molecule Inhibitors of NADPH Oxidase 4

(2010) Gábor Borbély et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

(2010) G. C. Van de Bittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioenergetic Profile Experiment using C2C12 Myoblast Cells

(2010) David G. Nicholls et al.   Jove-Journal of Visualized Experiments

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

(2009) Partha Mukhopadhyay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

(2009) Thomas L. Leto et al.   ANTIOXIDANTS & REDOX SIGNALING

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Understanding peroxynitrite biochemistry and its potential for treating human diseases

(2009) Joseph S. Beckman   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite

(2009) Adam Sikora et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine

(2007) Jacek Zielonka et al.   Nature Protocols