Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System

SignalP 6.0 predicts all five types of signal peptides using protein language models

(2022) Felix Teufel et al.   NATURE BIOTECHNOLOGY

Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor

(2021) Caroline W. Karanja et al.   ACS Infectious Diseases

Molecular Dissection of Escherichia coli CpdB: Roles of the N Domain in Catalysis and Phosphate Inhibition, and of the C Domain in Substrate Specificity and Adenosine Inhibition

(2021) Iralis López-Villamizar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclic di-AMP: Small molecule with big roles in bacteria

(2021) Sudhanshu Mudgal et al.   MICROBIAL PATHOGENESIS

A decade of research on the second messenger c-di-AMP

(2020) Wen Yin et al.   FEMS MICROBIOLOGY REVIEWS

Conserved strategies for pathogen evasion of cGAS–STING immunity

(2020) James B Eaglesham et al.   CURRENT OPINION IN IMMUNOLOGY

Cell wall‐anchored 5′‐nucleotidases in Gram‐positive cocci

(2019) Kar Yan Soh et al.   MOLECULAR MICROBIOLOGY

Cyclic di-AMP in host–pathogen interactions

(2018) Laura Devaux et al.   CURRENT OPINION IN MICROBIOLOGY

Coping with an Essential Poison: a Genetic Suppressor Analysis Corroborates a Key Function of c-di-AMP in Controlling Potassium Ion Homeostasis in Gram-Positive Bacteria

(2018) Fabian M. Commichau et al.   JOURNAL OF BACTERIOLOGY

High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival

(2018) Benjamin E. Rubin et al.   PLoS Genetics

Streptococcus suis – The “Two Faces” of a Pathobiont in the Porcine Respiratory Tract

(2018) Désirée Vötsch et al.   Frontiers in Microbiology

Streptococcus agalactiae Non-Pilus, Cell Wall-Anchored Proteins: Involvement in Colonization and Pathogenesis and Potential as Vaccine Candidates

(2018) Giampiero Pietrocola et al.   Frontiers in Immunology

The Surface-Exposed Protein SntA Contributes to Complement Evasion in Zoonotic Streptococcus suis

(2018) Simin Deng et al.   Frontiers in Immunology

Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in bacteria

(2018) Fabian M. Commichau et al.   JOURNAL OF BACTERIOLOGY

The manganese efflux system MntE contributes to the virulence of Streptococcus suis serotype 2

(2017) Jiali Xu et al.   MICROBIAL PATHOGENESIS

Characterization of a novel streptococcal heme-binding protein SntA and its interaction with host antioxidant protein AOP2

(2017) Yun Wan et al.   MICROBIAL PATHOGENESIS

Nucleotide circles of life and death

(2017) Lingyin Li   Nature Chemical Biology

Physiology and pathogenicity of cpdB deleted mutant of avian pathogenic Escherichia coli

(2017) Huifang Liu et al.   RESEARCH IN VETERINARY SCIENCE

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

(2016) Warrison A. Andrade et al.   Cell Host & Microbe

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

(2016) Ruchi Jain Dey et al.   Nature Chemical Biology

The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase

(2016) Iralis López-Villamizar et al.   PLoS One

ORION: a web server for protein fold recognition and structure prediction using evolutionary hybrid profiles

(2016) Yassine Ghouzam et al.   Scientific Reports

The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness

(2015) Arren Bar-Even et al.   BIOCHEMISTRY

Improving protein fold recognition with hybrid profiles combining sequence and structure evolution

(2015) Yassine Ghouzam et al.   BIOINFORMATICS

Structural and Biochemical Insight into the Mechanism of Rv2837c fromMycobacterium tuberculosisas a c-di-NMP Phosphodiesterase

(2015) Qing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decrease of colonization in the chicks' cecum and internal organs of Salmonella enterica serovar Pullorum by deletion of cpdB by Red system

(2015) Huifang Liu et al.   MICROBIAL PATHOGENESIS

Cyclic di-AMP mediates biofilm formation

(2015) Xian Peng et al.   MOLECULAR MICROBIOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function

(2014) Kamakshi Sureka et al.   CELL

Functional analysis of c-di-AMP phosphodiesterase, GdpP, in Streptococcus suis serotype 2

(2014) Bin Du et al.   MICROBIOLOGICAL RESEARCH

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) inMycobacterium tuberculosisleads to reduced virulence in a mouse model of infection

(2014) Jun Yang et al.   MOLECULAR MICROBIOLOGY

Two-Step Synthesis and Hydrolysis of Cyclic di-AMP in Mycobacterium tuberculosis

(2014) Kasi Manikandan et al.   PLoS One

Crosstalk between Mycobacterium tuberculosis and the host cell

(2014) Bappaditya Dey et al.   SEMINARS IN IMMUNOLOGY

Streptococcus suis, an important pig pathogen and emerging zoonotic agent—an update on the worldwide distribution based on serotyping and sequence typing

(2014) Guillaume Goyette-Desjardins et al.   Emerging Microbes & Infections

Cyclic Dinucleotides and the Innate Immune Response

(2013) Olga Danilchanka et al.   CELL

Contribution of the two domains ofE. coli5′-nucleotidase to substrate specificity and catalysis

(2013) Ulrike Krug et al.   FEBS LETTERS

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Spatial positioning of cell wall-anchored virulence factors in Gram-positive bacteria

(2012) Hélène Bierne et al.   CURRENT OPINION IN MICROBIOLOGY

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Protein secretion and surface display in Gram-positive bacteria

(2012) O. Schneewind et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis

(2011) Yaara Oppenheimer-Shaanan et al.   EMBO REPORTS

TroA of Streptococcus suis Is Required for Manganese Acquisition and Full Virulence

(2011) P. J. W. Schreur et al.   JOURNAL OF BACTERIOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Identification ofStreptococcus suisgenes preferentially expressed under iron starvation by selective capture of transcribed sequences

(2009) Wei Li et al.   FEMS MICROBIOLOGY LETTERS

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL