Impact of Neutrophil Extracellular Traps on Thrombosis Formation: New Findings and Future Perspective

Plasma tumor DNA is associated with increased risk of venous thromboembolism in metastatic castration‐resistant cancer patients

(2021) Vincenza Conteduca et al.   INTERNATIONAL JOURNAL OF CANCER

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

Therapeutic strategies for thrombosis: new targets and approaches

(2020) Nigel Mackman et al.   NATURE REVIEWS DRUG DISCOVERY

Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update

(2020) Aldo Bonaventura et al.   Cells

Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock

(2020) Emeka B. Okeke et al.   BIOMATERIALS

Neutrophil Extracellular Traps Participate in Cardiovascular Diseases

(2020) Yvonne Döring et al.   CIRCULATION RESEARCH

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

(2020) Hawa Racine Thiam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Mechanisms of NETosis

(2020) Hawa Racine Thiam et al.   Annual Review of Cell and Developmental Biology

Neutrophil Extracellular Trap Degradation by Differently Polarized Macrophage Subsets

(2020) Patrick Haider et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

(2020) Victoria Mutua et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Anti‐NET antibodies and impaired NET degradation in antiphospholipid syndrome

(2020) Yu Zuo et al.   Arthritis & Rheumatology

Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review

(2020) Seung-Woo Kim et al.   Cells

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

(2019) Elodie Laridan et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Neutrophil extracellular traps in thrombi retrieved during interventional treatment of ischemic arterial diseases

(2019) Ádám Z. Farkas et al.   THROMBOSIS RESEARCH

Neutrophils: back in the thrombosis spotlight

(2019) Denis F. Noubouossie et al.   BLOOD

Citrullinated histone H3, a biomarker for neutrophil extracellular trap formation, predicts the risk of mortality in patients with cancer

(2019) Ella Grilz et al.   BRITISH JOURNAL OF HAEMATOLOGY

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

(2019) Yohei Hisada et al.   HAEMATOLOGICA

Neutrophil Extracellular Traps

(2019) Charlotte Thålin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review

(2019) Robert Goggs et al.   VETERINARY PATHOLOGY

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils—Important Communicators in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

(2019) Lina Wirestam et al.   Frontiers in Immunology

Recombinant human ADAMTS13 treatment and anti‐NET strategies enhance skin allograft survival in mice

(2019) Siu Ling Wong et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial InjuryNovelty and Significance

(2018) Grégory Franck et al.   CIRCULATION RESEARCH

Mechanisms and disease relevance of neutrophil extracellular trap formation

(2018) Kristof Van Avondt et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense duringKlebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

(2018) Theodora A. M. Claushuis et al.   JOURNAL OF IMMUNOLOGY

Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients

(2018) L.-M. Mauracher et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome

(2018) Maarten van der Linden et al.   RHEUMATOLOGY

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice

(2018) Yongzhi Wang et al.   Scientific Reports

Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease

(2018) Miriam Sjåstad Langseth et al.   European Journal of Preventive Cardiology

The role of neutrophils in thrombosis

(2018) Sargam Kapoor et al.   THROMBOSIS RESEARCH

Pancreatic Cancer-Induced Neutrophil Extracellular Traps: A Potential Contributor to Cancer-Associated Thrombosis

(2017) Norbaini Abdol Razak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions

(2017) Simon F De Meyer et al.   International Journal of Stroke

Anti-inflammatory approaches to ischaemic stroke prevention

(2017) Peter J Kelly et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Neutrophil Extracellular Traps Promote Hypercoagulability in Patients With Sepsis

(2017) Shuofei Yang et al.   SHOCK

Thrombomodulin alfa attenuates the procoagulant effect and cytotoxicity of extracellular histones through the promotion of protein C activation

(2017) Keita Osada et al.   THROMBOSIS RESEARCH

Lipopolysaccharide-induced neutrophil extracellular trap formation in canine neutrophils is dependent on histone H3 citrullination by peptidylarginine deiminase

(2017) Ronald H.L. Li et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis

(2017) He Meng et al.   Arthritis & Rheumatology

Complement component 5 promotes lethal thrombosis

(2017) Tomohiro Mizuno et al.   Scientific Reports

Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis

(2017) Ana C. Leal et al.   Scientific Reports

In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps

(2016) Denis F. Noubouossie et al.   BLOOD

Global Burden of Thrombosis: Table.

(2016) Aaron M. Wendelboe et al.   CIRCULATION RESEARCH

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Decreased Neutrophil Extracellular Trap Degradation in Shiga Toxin-Associated Haemolytic Uraemic Syndrome

(2016) Jonatan Leffler et al.   Journal of Innate Immunity

Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome

(2016) Maria Victoria Ramos et al.   Journal of Innate Immunity

Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

(2016) Scott M. Stevens et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice

(2016) Osama M. El-Sayed et al.   JOURNAL OF VASCULAR SURGERY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Thrombus Histology Suggests Cardioembolic Cause in Cryptogenic Stroke

(2016) Tobias Boeckh-Behrens et al.   STROKE

Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway

(2016) Trang T. Vu et al.   THROMBOSIS AND HAEMOSTASIS

Extracellular histones induce tissue factor expression in vascular endothelial cells via TLR and activation of NF-κB and AP-1

(2016) Xinyu Yang et al.   THROMBOSIS RESEARCH

Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

(2016) Silvia Guglietta et al.   Nature Communications

NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways

(2016) Joshua Yuen et al.   Frontiers in Immunology

The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis

(2016) Andrew S. Kimball et al.   Frontiers in Immunology

Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in SepsisSignificance

(2015) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

P-selectin promotes neutrophil extracellular trap formation in mice

(2015) J. Etulain et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases

(2015) April Barnado et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Influence of complement on neutrophil extracellular trap release induced by bacteria

(2015) L. J. Palmer et al.   JOURNAL OF PERIODONTAL RESEARCH

Venous thrombosis and cancer: from mouse models to clinical trials

(2015) Y. Hisada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies

(2015) M. Jiménez-Alcázar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Ruxolitinib versus Standard Therapy for the Treatment of Polycythemia Vera

(2015) Alessandro M. Vannucchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome

(2015) Srilakshmi Yalavarthi et al.   Arthritis & Rheumatology

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

(2014) A. S. Savchenko et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Syndromes of Thrombotic Microangiopathy

(2014) James N. George et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Neutrophil Extracellular Trap Levels Predict Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation

(2013) Yasuyuki Arai et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

(2013) Bassem Mohammed et al.   Nutrients

Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis

(2012) Maurits L. van Montfoort et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense

(2011) T. G. Loof et al.   BLOOD

Sepsis, thrombosis and organ dysfunction

(2011) Nicola Semeraro et al.   THROMBOSIS RESEARCH