Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

(2019) Sebastian Boeltz et al.   CELL DEATH AND DIFFERENTIATION

Hyperglycemia Induces Neutrophil Extracellular Traps Formation Through an NADPH Oxidase-Dependent Pathway in Diabetic Retinopathy

(2019) Luoziyi Wang et al.   Frontiers in Immunology

Inflammasomes, Neutrophil Extracellular Traps, and Cholesterol

(2019) Alan R. Tall et al.   JOURNAL OF LIPID RESEARCH

Novel findings in neutrophil biology and their impact on cardiovascular disease

(2019) Aldo Bonaventura et al.   CARDIOVASCULAR RESEARCH

Neutrophils and NETS in modulating acute and chronic inflammation

(2019) Fernanda Vargas e Silva Castanheira et al.   BLOOD

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

(2019) Marrah E Lachowicz-Scroggins et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Baseline neutrophil-to-lymphocyte ratio is associated with long-term T2D remission after metabolic surgery

(2019) Aldo Bonaventura et al.   ACTA DIABETOLOGICA

Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction

(2019) Thomas M. Hofbauer et al.   BASIC RESEARCH IN CARDIOLOGY

The NLRP3 inflammasome in acute myocardial infarction

(2019) Adolfo Gabriele Mauro et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Neutrophil extracellular traps (NET) induced by different stimuli: A comparative proteomic analysis

(2019) Andrea Petretto et al.   PLoS One

Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis

(2019) Ying Jin et al.   Journal of the American Heart Association

Guidelines for evaluating myocardial cell death

(2019) Paras K Mishra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Extracellular DNA NET-Works With Dire Consequences for Health

(2019) Nicoletta Sorvillo et al.   CIRCULATION RESEARCH

Diabetes and Vascular Disease: is it all about Glycemia?

(2019) Alessandra Vecchié et al.   CURRENT PHARMACEUTICAL DESIGN

The IL-1 family of cytokines and receptors in rheumatic diseases

(2019) Charles Anthony Dinarello   Nature Reviews Rheumatology

Glucose associated NETosis in patients with ST-elevation myocardial infarction: an observational study

(2019) Ragnhild Helseth et al.   BMC Cardiovascular Disorders

Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction

(2019) Jing Liu et al.   Scientific Reports

Increased plasmatic NETs by-products in patients in severe obesity

(2019) Marco D’Abbondanza et al.   Scientific Reports

Neutrophil extracellular traps and monocyte subsets at the culprit lesion site of myocardial infarction patients

(2019) Andreas Mangold et al.   Scientific Reports

Interleukin-1β Mediates Arterial Thrombus Formation via NET-Associated Tissue Factor

(2019) Luca Liberale et al.   Journal of Clinical Medicine

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

(2018) Lisa Menegazzo et al.   ACTA DIABETOLOGICA

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

Aspirin in primary prevention for patients with diabetes: still a matter of debate

(2018) Aldo Bonaventura et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Obesity phenotypes and their paradoxical association with cardiovascular diseases

(2018) Alessandra Vecchié et al.   European Journal of Internal Medicine

Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging

(2018) Siu Ling Wong et al.   FASEB JOURNAL

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

(2018) Brendan M. Everett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases

(2018) Luca Liberale et al.   THROMBOSIS AND HAEMOSTASIS

Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease

(2018) Miriam Sjåstad Langseth et al.   European Journal of Preventive Cardiology

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

(2018) Stefano Toldo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases

(2018) Jonas Hahn et al.   FASEB JOURNAL

Resistin exerts a beneficial role in atherosclerotic plaque inflammation by inhibiting neutrophil migration

(2018) Luca Liberale et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Obesity-induced Endothelial Dysfunction is Prevented by Neutrophil Extracellular Trap Inhibition

(2018) Hui Wang et al.   Scientific Reports

Innate immunity as a target for acute cardioprotection

(2018) Coert J Zuurbier et al.   CARDIOVASCULAR RESEARCH

Inflammation and pericarditis: Are neutrophils actors behind the scenes?

(2018) Aldo Bonaventura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines

(2017) Danielle M. Clancy et al.   FEBS Journal

Early reduction of matrix metalloproteinase-8 serum levels is associated with leptin drop and predicts diabetes remission after bariatric surgery

(2017) Luca Liberale et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

White blood cell subtypes and risk of type 2 diabetes

(2017) Hongmei Zhang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients

(2017) Agostina Carestia et al.   PLoS One

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

(2017) Fawaz Awad et al.   PLoS One

In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps

(2016) Denis F. Noubouossie et al.   BLOOD

NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count

(2016) J. Qin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Beyond the grave: When is cell death critical for immunity to infection?

(2016) HN Stephenson et al.   CURRENT OPINION IN IMMUNOLOGY

NETosis Delays Diabetic Wound Healing in Mice and Humans

(2016) Gian Paolo Fadini et al.   DIABETES

Cellular recruitment in myocardial ischaemia/reperfusion injury

(2016) Aldo Bonaventura et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study

(2016) J.-H. Park et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Granulopoiesis and granules of human neutrophils

(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse

(2016) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Neutrophil extracellular traps — the dark side of neutrophils

(2016) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

The Time Course of Markers of Neutrophil Extracellular Traps in Patients Undergoing Revascularisation for Acute Myocardial Infarction or Stable Angina Pectoris

(2016) Ragnhild Helseth et al.   MEDIATORS OF INFLAMMATION

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice

(2016) Quinte Braster et al.   PLoS One

Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy

(2015) Lan Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Inflammasome in Myocardial Injury and Cardiac Remodeling

(2015) Stefano Toldo et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

(2015) Dimitrios A. Stakos et al.   EUROPEAN HEART JOURNAL

TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion

(2015) Thibaut Quillard et al.   EUROPEAN HEART JOURNAL

Metabolic requirements for neutrophil extracellular traps formation

(2015) Oscar Rodríguez-Espinosa et al.   IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

NETosis is induced by high glucose and associated with type 2 diabetes

(2014) Lisa Menegazzo et al.   ACTA DIABETOLOGICA

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart

(2014) Stefano Toldo et al.   CARDIOVASCULAR RESEARCH

Neutrophils Cast NETs in Atherosclerosis

(2014) Yvonne Döring et al.   CIRCULATION RESEARCH

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes

(2014) Y. Wang et al.   DIABETES

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

(2013) Julian I. Borissoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

(2013) Byung-Cheol Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell-Free Circulating DNA: A New Biomarker for the Acute Coronary Syndrome

(2013) Ming Cui et al.   CARDIOLOGY

Neutrophils and type 1 autoimmune diabetes

(2013) Manuela Battaglia   CURRENT OPINION IN HEMATOLOGY

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Prognostic value of culprit site neutrophils in acute coronary syndrome

(2013) Klaus Distelmaier et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation

(2013) Manjunath B. Joshi et al.   FEBS LETTERS

Reduced Blood Leukocyte and Neutrophil Numbers in the Pathogenesis of Type 1 Diabetes

(2013) M. Harsunen et al.   HORMONE AND METABOLIC RESEARCH

Blocking Interleukin-1 as a Novel Therapeutic Strategy for Secondary Prevention of Cardiovascular Events

(2012) Antonio Abbate et al.   BIODRUGS

Neutrophil dysfunction induced by hyperglycemia: modulation of myeloperoxidase activity

(2012) Cláudia de Souza Ferreira et al.   CELL BIOCHEMISTRY AND FUNCTION

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction

(2012) Xiaofei Li et al.   THROMBOSIS AND HAEMOSTASIS

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction

(2009) Klaus Distelmaier et al.   THROMBOSIS AND HAEMOSTASIS

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

(2008) M. E. Stegenga et al.   BLOOD