Uncovering a Cryptic Site of Malaria Pathogenesis: Models to Study Interactions Between Plasmodium and the Bone Marrow

Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium berghei

(2022) Franziska Hentzschel et al.   Science Advances

Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin

(2021) Buket Baddal et al.   Pathogens

Comprehensive phenotyping of erythropoiesis in human bone marrow: Evaluation of normal and ineffective erythropoiesis

(2021) Hongxia Yan et al.   AMERICAN JOURNAL OF HEMATOLOGY

Biomechanical cues as master regulators of hematopoietic stem cell fate

(2021) Honghu Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Erythrocyte CD55 mediates the internalization of Plasmodium falciparum parasites

(2021) Bikash Shakya et al.   eLife

Molecular and cellular mechanisms that regulate human erythropoiesis

(2021) Alexis Leon Caulier et al.   BLOOD

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis

(2020) Gaelle Neveu et al.   BLOOD

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

(2020) Myriam L. R. Haltalli et al.   NATURE CELL BIOLOGY

Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate

(2019) Carmen G. Palii et al.   Cell Stem Cell

Comparing the two leading erythroid lines BEL-A and HUDEP-2

(2019) Deborah E. Daniels et al.   HAEMATOLOGICA

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

(2019) Timothy J. Satchwell et al.   Nature Communications

Immune monitoring using mass cytometry and related high-dimensional imaging approaches

(2019) Felix J. Hartmann et al.   Nature Reviews Rheumatology

Developmental differences between neonatal and adult human erythropoiesis

(2018) Hongxia Yan et al.   AMERICAN JOURNAL OF HEMATOLOGY

In-depth phenotypic characterization of reticulocyte maturation using mass cytometry

(2018) Richard Thomson-Luque et al.   BLOOD CELLS MOLECULES AND DISEASES

Plasmodium falciparum malaria skews globin gene expression balance in in-vitro haematopoietic stem cell culture system: Its implications in malaria associated anemia

(2018) Vrushali Pathak et al.   EXPERIMENTAL PARASITOLOGY

Erythropoiesis: insights into pathophysiology and treatments in 2017

(2018) Andrea Zivot et al.   MOLECULAR MEDICINE

Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection

(2018) Nicanor Obaldia et al.   mBio

A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy

(2018) Rebecca S. Lee et al.   Nature Communications

Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow

(2018) Mariana De Niz et al.   Science Advances

Rodent malaria models: insights into human disease and parasite biology

(2018) Mariana De Niz et al.   CURRENT OPINION IN MICROBIOLOGY

CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants ofPlasmodium falciparuminvasion

(2017) Usheer Kanjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

(2017) Kongtana Trakarnsanga et al.   Nature Communications

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells

(2016) Felix C. Giani et al.   Cell Stem Cell

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points

(2016) Maria L. Vainieri et al.   Open Biology

A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs

(2016) Yoann Duffier et al.   Scientific Reports

The erythroblastic island as an emerging paradigm in the anemia of inflammation

(2015) Jimmy Hom et al.   IMMUNOLOGIC RESEARCH

A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion

(2015) E. S. Egan et al.   SCIENCE

Distinct Mechanisms of Inadequate Erythropoiesis Induced by Tumor Necrosis Factor Alpha or Malarial Pigment

(2015) Abigail A. Lamikanra et al.   PLoS One

Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E

(2014) J. Li et al.   BLOOD

Severity of anaemia is associated with bone marrow haemozoin in children exposed toPlasmodium falciparum

(2014) Ruth Aguilar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS

(2014) Kongtana Trakarnsanga et al.   PLoS One

Plasmodium falciparum transmission stages accumulate in the human bone marrow

(2014) R. Joice et al.   Science Translational Medicine

Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo

(2013) J. Hu et al.   BLOOD

Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow

(2013) R. Aguilar et al.   BLOOD

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

(2013) Ryo Kurita et al.   PLoS One

Hematopoiesis: A Human Perspective

(2012) Sergei Doulatov et al.   Cell Stem Cell

Ex-vivo generation of human red cells for transfusion

(2012) David J. Anstee et al.   CURRENT OPINION IN HEMATOLOGY

The Role of Animal Models for Research on Severe Malaria

(2012) Alister G. Craig et al.   PLoS Pathogens

Proof of principle for transfusion of in vitro-generated red blood cells

(2011) M.-C. Giarratana et al.   BLOOD

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

(2011) S. M. Hattangadi et al.   BLOOD

P. falciparum Modulates Erythroblast Cell Gene Expression in Signaling and Erythrocyte Production Pathways

(2011) Pamela A. Tamez et al.   PLoS One

Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

(2011) Jessica Dias et al.   STEM CELLS AND DEVELOPMENT

Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal

(2010) O. A. Skorokhod et al.   BLOOD

In Vitro Genetic Analysis of an Erythrocyte Determinant of Malaria Infection

(2010) Amy K. Bei et al.   JOURNAL OF INFECTIOUS DISEASES

Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection

(2009) P. A. Tamez et al.   BLOOD

Erythropoiesis: Model systems, molecular regulators, and developmental programs

(2009) Asterios S. Tsiftsoglou et al.   IUBMB LIFE