The Role of Efflux and Physiological Adaptation in Biofilm Tolerance and Resistance

Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria

(2016) Donald C. Sheppard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention

(2016) John S. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biofilms and Cyclic di-GMP (c-di-GMP) Signaling: Lessons fromPseudomonas aeruginosaand Other Bacteria

(2016) Martina Valentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

Efflux as a Glutaraldehyde Resistance Mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa Biofilms

(2015) Amit Vikram et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of Stress Responses to Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms

(2015) Philip S. Stewart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

RNA Futile Cycling in Model Persisters Derived from MazF Accumulation

(2015) W. W. K. Mok et al.   mBio

Stationary-Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery

(2015) Katherine G. Völzing et al.   mBio

Inhibition of stationary phase respiration impairs persister formation in E. coli

(2015) Mehmet A. Orman et al.   Nature Communications

Differential Roles of RND Efflux Pumps in Antimicrobial Drug Resistance of Sessile and Planktonic Burkholderia cenocepacia Cells

(2014) Silvia Buroni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

(2014) D. Lebeaux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

BrlR fromPseudomonas aeruginosais a c-di-GMP-responsive transcription factor

(2014) Jacob R. Chambers et al.   MOLECULAR MICROBIOLOGY

The Contribution of Antibiotic Resistance Mechanisms in Clinical Burkholderia cepacia Complex Isolates: An Emphasis on Efflux Pump Activity

(2014) Sung-Pin Tseng et al.   PLoS One

Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms

(2014) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Toxin-Antitoxin Systems as Multilevel Interaction Systems

(2014) Nathalie Goeders et al.   Toxins

Metabolic aspects of bacterial persisters

(2014) Marcel Prax et al.   Frontiers in Cellular and Infection Microbiology

The role of metabolism in bacterial persistence

(2014) Stephanie M. Amato et al.   Frontiers in Microbiology

Chronic wounds and the medical biofilm paradigm

(2014) R.D. Wolcott et al.   Journal of Wound Care

Involvement of toxin-antitoxin modules inBurkholderia cenocepaciabiofilm persistence

(2014) Heleen Van Acker et al.   Pathogens and Disease

Key Role for Efflux in the Preservative Susceptibility and Adaptive Resistance of Burkholderia cepacia Complex Bacteria

(2013) Laura Rushton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dormancy Is Not Necessary or Sufficient for Bacterial Persistence

(2013) Mehmet A. Orman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The role of bacterial biofilms in chronic infections

(2013) Thomas Bjarnsholt   APMIS

Bacterial Persister Cell Formation and Dormancy

(2013) Thomas K. Wood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Microbial Persistence and the Road to Drug Resistance

(2013) Nadia R. Cohen et al.   Cell Host & Microbe

mazEF-mediated programmed cell death in bacteria: “What is this?”

(2013) Bhaskar Chandra Mohan Ramisetty et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate

(2013) Christopher F. Schuster et al.   FEMS MICROBIOLOGY LETTERS

Inhibition of multidrug efflux as a strategy to prevent biofilm formation

(2013) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The MerR-Like Regulator BrlR Confers Biofilm Tolerance by Activating Multidrug Efflux Pumps in Pseudomonas aeruginosa Biofilms

(2013) J. Liao et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Molecular Mechanism of Bacterial Persistence by HipA

(2013) Elsa Germain et al.   MOLECULAR CELL

Biofilm-Grown Burkholderia cepacia Complex Cells Survive Antibiotic Treatment by Avoiding Production of Reactive Oxygen Species

(2013) Heleen Van Acker et al.   PLoS One

Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm

(2013) Sara M. Soto   Virulence

Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

(2013) Steve P. Bernier et al.   PLoS Genetics

Bacterial Persistence and Toxin-Antitoxin Loci

(2012) Kenn Gerdes et al.   Annual Review of Microbiology

Hypoxia Increases Antibiotic Resistance in Pseudomonas aeruginosa through Altering the Composition of Multidrug Efflux Pumps

(2012) Bettina Schaible et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

(2012) L. Fernandez et al.   CLINICAL MICROBIOLOGY REVIEWS

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The MerR-Like Transcriptional Regulator BrlR Contributes to Pseudomonas aeruginosa Biofilm Tolerance

(2012) Julie Liao et al.   JOURNAL OF BACTERIOLOGY

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

Molecular Mechanisms of Chlorhexidine Tolerance in Burkholderia cenocepacia Biofilms

(2011) Tom Coenye et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies

(2011) M. Fauvart et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Deciphering the Role of RND Efflux Transporters in Burkholderia cenocepacia

(2011) Silvia Bazzini et al.   PLoS One

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis

(2010) James P Folsom et al.   BMC MICROBIOLOGY

Response of sessile cells to stress: from changes in gene expression to phenotypic adaptation

(2010) Tom Coenye   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

(2009) Silvia Buroni et al.   BMC MICROBIOLOGY

Novel persistence genes inPseudomonas aeruginosaidentified by high-throughput screening

(2009) Valerie N. De Groote et al.   FEMS MICROBIOLOGY LETTERS

Energy production genessucBandubiF  are involved in persister survival and tolerance to multiple antibiotics and stresses inEscherichia coli

(2009) Chao Ma et al.   FEMS MICROBIOLOGY LETTERS

In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteria

(2009) E. Peeters et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bacterial persistence: some new insights into an old phenomenon

(2009) R. Jayaraman   JOURNAL OF BIOSCIENCES

Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli

(2008) S. Hansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

(2008) M. Kvist et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toxin-Antitoxin Systems in Escherichia coli Influence Biofilm Formation through YjgK (TabA) and Fimbriae

(2008) Y. Kim et al.   JOURNAL OF BACTERIOLOGY

Involvement of a Novel Efflux System in Biofilm-Specific Resistance to Antibiotics

(2008) L. Zhang et al.   JOURNAL OF BACTERIOLOGY

Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes

(2008) Sünje Johanna Pamp et al.   MOLECULAR MICROBIOLOGY

Physiological heterogeneity in biofilms

(2008) Philip S. Stewart et al.   NATURE REVIEWS MICROBIOLOGY