Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity

Novel Features of DAG-Activated PKC Isozymes Reveal a Conserved 3-D Architecture

(2016) Iva Lučić et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamics and Membrane Interactions of Protein Kinase C

(2015) Tatyana I. Igumenova   BIOCHEMISTRY

Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C-α

(2014) Brian P. Ziemba et al.   BIOCHEMISTRY

Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

(2014) J. C. Riches et al.   BLOOD

Charge Density Influences C1 Domain Ligand Affinity and Membrane Interactions

(2014) Jessica S. Kelsey et al.   CHEMBIOCHEM

C1 Domains: Structure and Ligand-Binding Properties

(2014) Joydip Das et al.   CHEMICAL REVIEWS

Interfacial Partitioning of a Loop Hinge Residue Contributes to Diacylglycerol Affinity of Conserved Region 1 Domains

(2014) Mikaela D. Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

(2014) Yongmei Pu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interactions of Protein Kinase C-α C1A and C1B Domains with Membranes: A Combined Computational and Experimental Study

(2014) Jianing Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation

(2013) H. Subramanian et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

(2013) Jeffrey S Iwig et al.   eLife

Molecular Basis for Failure of “Atypical” C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester

(2012) Tamas Geczy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

(2012) Deirdre M. Fuller et al.   PLoS One

Crystal Structure and Allosteric Activation of Protein Kinase C βII

(2011) Thomas A. Leonard et al.   CELL

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling

(2011) Anika Stadtmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-Kinase Regulates Plasma Membrane Targeting of the Ras-specific Exchange Factor RasGRP1

(2011) Bari Zahedi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing the Determinants of Diacylglycerol Binding Affinity in the C1B Domain of Protein Kinase Cα

(2011) Mikaela D. Stewart et al.   JOURNAL OF MOLECULAR BIOLOGY

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis

(2010) C. Carbo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CalDAG-GEFI and platelet activation

(2010) Lucia Stefanini et al.   PLATELETS

Taxonomy and function of C1 protein kinase C homology domains

(2010) James H. Hurley et al.   PROTEIN SCIENCE

Biochemical Characterization of Hyperactive β2-Chimaerin Mutants Revealed an Enhanced Exposure of C1 and Rac-GAP Domains

(2009) Maria Soledad Sosa et al.   BIOCHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Wealth of Opportunity - The C1 Domain as a Target for Drug Development

(2008) P. Blumberg et al.   CURRENT DRUG TARGETS

Lipid binding domains: more than simple lipid effectors

(2008) Robert V. Stahelin   JOURNAL OF LIPID RESEARCH

Lipid activation of protein kinases

(2008) Alexandra C. Newton   JOURNAL OF LIPID RESEARCH

Rationally designed peptide regulators of protein kinase C

(2008) Eric N. Churchill et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM