Molecular Basis for Failure of “Atypical” C1 Domain of Vav1 to Bind Diacylglycerol/Phorbol Ester

Crystal Structure and Allosteric Activation of Protein Kinase C βII

(2011) Thomas A. Leonard et al.   CELL

Probing the Determinants of Diacylglycerol Binding Affinity in the C1B Domain of Protein Kinase Cα

(2011) Mikaela D. Stewart et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities

(2010) Or Raifman et al.   CHEMBIOCHEM

Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir

(2010) Jonathan M. Miller et al.   MOLECULAR PHARMACEUTICS

Taxonomy and function of C1 protein kinase C homology domains

(2010) James H. Hurley et al.   PROTEIN SCIENCE

VASCo: computation and visualization of annotated protein surface contacts

(2009) Georg Steinkellner et al.   BMC BIOINFORMATICS

Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family

(2008) Jun Chen et al.   BIOCHEMICAL JOURNAL

Wealth of Opportunity - The C1 Domain as a Target for Drug Development

(2008) P. Blumberg et al.   CURRENT DRUG TARGETS

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

(2008) Jonathan Rapley et al.   EMBO REPORTS

Vav1: A hematopoietic signal transduction molecule involved in human malignancies

(2008) Shulamit Katzav   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Conformationally Constrained Analogues of Diacylglycerol. 30. An Investigation of Diacylglycerol-lactones Containing Heteroaryl Groups Reveals Compounds with High Selectivity for Ras Guanyl Nucleotide-Releasing Proteins

(2008) Saïd El Kazzouli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities

(2008) Dehui Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

(2008) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

Physiological Role for Phosphatidic Acid in the Translocation of the Novel Protein Kinase C Apl II in Aplysia Neurons

(2008) C. A. Farah et al.   MOLECULAR AND CELLULAR BIOLOGY