Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction

Myc induced replicative stress response: How to cope with it and exploit it

(2015) Sara Rohban et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

(2015) Cohen Idan et al.   Scientific Reports

Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors

(2014) L Molife et al.   Journal of Hematology & Oncology

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling

(2014) J. C. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERK-ing up autophagy during MYC-induced tumorigenesis

(2013) Souvik Dey et al.   Autophagy

Activation of a PGC-1-related Coactivator (PRC)-dependent Inflammatory Stress Program Linked to Apoptosis and Premature Senescence

(2013) Natalie Gleyzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

(2013) Vishal M. Gohil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein

(2012) Xin He et al.   DEVELOPMENTAL DYNAMICS

PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics

(2012) Kiran Mahajan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein degradation and the stress response

(2012) Karin Flick et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance

(2012) Stefano Campaner et al.   Cell Division

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

(2011) Richard C. Scarpulla   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

GSK-3 inhibition by an orally active small molecule increases bone mass in rats

(2011) Richard Marsell et al.   BONE

Tumor microenvironment: becoming sick of Myc

(2011) Jonathan R. Whitfield et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

PGC-1-related Coactivator (PRC), a Sensor of Metabolic Stress, Orchestrates a Redox-sensitive Program of Inflammatory Gene Expression

(2011) Natalie Gleyzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Primary Response Genes

(2011) Trent Fowler et al.   MOLECULAR CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation of Akt Is Essential for the Propagation of Mitochondrial Respiratory Stress Signaling and Activation of the Transcriptional Coactivator Heterogeneous Ribonucleoprotein A2

(2010) Manti Guha et al.   MOLECULAR BIOLOGY OF THE CELL

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

(2009) NM Luheshi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Methylation of 12S rRNA Is Necessary for In Vivo Stability of the Small Subunit of the Mammalian Mitochondrial Ribosome

(2009) Metodi D. Metodiev et al.   Cell Metabolism

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

PGC-1-related Coactivator Complexes with HCF-1 and NRF-2β in Mediating NRF-2(GABP)-dependent Respiratory Gene Expression

(2008) Kristel Vercauteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Hairpin RNA-mediated Silencing of PRC (PGC-1-related Coactivator) Results in a Severe Respiratory Chain Deficiency Associated with the Proliferation of Aberrant Mitochondria

(2008) Kristel Vercauteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS