Activation of a PGC-1-related Coactivator (PRC)-dependent Inflammatory Stress Program Linked to Apoptosis and Premature Senescence

Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein

(2012) Xin He et al.   DEVELOPMENTAL DYNAMICS

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress

(2011) Richard C. Scarpulla   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets

(2011) D C Gilbert et al.   BRITISH JOURNAL OF CANCER

Tumor microenvironment: becoming sick of Myc

(2011) Jonathan R. Whitfield et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

PGC-1-related Coactivator (PRC), a Sensor of Metabolic Stress, Orchestrates a Redox-sensitive Program of Inflammatory Gene Expression

(2011) Natalie Gleyzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS Quenching Potential of the Epidermal Cornified Cell Envelope

(2011) Wilbert P. Vermeij et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

(2011) Vittorio Calabrese et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of Primary Response Genes

(2011) Trent Fowler et al.   MOLECULAR CELL

PGC-1 coactivators in the cardiovascular system

(2011) Ian S. Patten et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular pathways and targets in cancer-related inflammation

(2010) Alberto Mantovani et al.   ANNALS OF MEDICINE

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

(2010) Gabriel Loor et al.   FREE RADICAL BIOLOGY AND MEDICINE

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Skin Cornification Proteins Provide Global Link between ROS Detoxification and Cell Migration during Wound Healing

(2010) Wilbert P. Vermeij et al.   PLoS One

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy

(2009) NM Luheshi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Methylation of 12S rRNA Is Necessary for In Vivo Stability of the Small Subunit of the Mammalian Mitochondrial Ribosome

(2009) Metodi D. Metodiev et al.   Cell Metabolism

In Situ Modulation of Oxidative Stress: A Novel and Efficient Strategy to Kill Cancer Cells

(2009) J. Verrax et al.   CURRENT MEDICINAL CHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

(2008) Michael Muller   ANTIOXIDANTS & REDOX SIGNALING

Inflammation and cancer: The oncogene-driven connection

(2008) Maria Grazia Borrello et al.   CANCER LETTERS

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS

(2008) Tatyana A. Klimova et al.   FASEB JOURNAL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

PGC-1-related Coactivator Complexes with HCF-1 and NRF-2β in Mediating NRF-2(GABP)-dependent Respiratory Gene Expression

(2008) Kristel Vercauteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Hairpin RNA-mediated Silencing of PRC (PGC-1-related Coactivator) Results in a Severe Respiratory Chain Deficiency Associated with the Proliferation of Aberrant Mitochondria

(2008) Kristel Vercauteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS