Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition

(2011) Andreas Höglund et al.   CELL CYCLE

Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

(2011) A. Hoglund et al.   CLINICAL CANCER RESEARCH

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

(2011) David W. Schoppy et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

(2011) Matilde Murga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

(2011) K. A. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner

(2010) O. Gilad et al.   CANCER RESEARCH

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

(2009) Stefano Campaner et al.   NATURE CELL BIOLOGY

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress

(2009) Kristin Robinson et al.   PLoS One

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

(2008) Yen-Chun Liu et al.   PLoS One