The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2

Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes

(2015) T. E. Thorvaldsen et al.   MOLECULAR CANCER RESEARCH

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

(2015) Mira I Pronobis et al.   eLife

Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin Signaling

(2014) Evan R. Delgado et al.   AMERICAN JOURNAL OF PATHOLOGY

LEF1 and B9L Shield  -Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors

(2014) M. de la Roche et al.   CANCER RESEARCH

The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin

(2014) Ying Feng et al.   CELLULAR SIGNALLING

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

(2014) Teemu Haikarainen et al.   CURRENT PHARMACEUTICAL DESIGN

Testing Models of the APC Tumor Suppressor/β-Catenin Interaction Reshapes Our View of the Destruction Complex in Wnt Signaling

(2014) Robert J. Yamulla et al.   GENETICS

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

(2014) Ezgi Kunttas-Tatli et al.   MOLECULAR BIOLOGY OF THE CELL

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

(2014) Paul A. DaRosa et al.   NATURE

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction

(2013) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4

(2013) Teemu Haikarainen et al.   PLoS One

Functional Comparison of Human Adenomatous Polyposis Coli (APC) and APC-Like in Targeting Beta-Catenin for Degradation

(2013) Jean Schneikert et al.   PLoS One

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition

(2012) Matias Casás-Selves et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Reversible Modification of Adenomatous Polyposis Coli (APC) with K63-linked Polyubiquitin Regulates the Assembly and Activity of the β-Catenin Destruction Complex

(2012) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation

(2012) Shree Harsha Vijaya Chandra et al.   PLoS One

WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

(2012) Richard G. James et al.   PLoS One

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells

(2012) Renyue Bao et al.   PLoS One

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

(2012) S. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Ring finger protein 146/Iduna is a Poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase

(2012) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

(2011) David M. Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/ -catenin signaling

(2011) A. Scholer-Dahirel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

(2011) C. Mendoza-Topaz et al.   Open Biology

Isoreserpine promotes β-catenin degradation via Siah-1 up-regulation in HCT116 colon cancer cells

(2009) Jungsug Gwak et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PARsing the Phrase “All in for Axin”— Wnt Pathway Targets in Cancer

(2009) Eric R. Fearon   CANCER CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Wnt Signaling from Development to Disease: Insights from Model Systems

(2009) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Tankyrase function at telomeres, spindle poles, and beyond

(2007) Susan J. Hsiao et al.   BIOCHIMIE