Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders – Advances and challenges

Engineered antigen-specific regulatory T cells for autoimmune skin conditions

(2021) Zhussipbek Mukhatayev et al.   AUTOIMMUNITY REVIEWS

Immune regulation in renal inflammation

(2021) Katrin Neumann et al.   CELL AND TISSUE RESEARCH

The Complex Role of Regulatory T Cells in Immunity and Aging

(2021) Lourdes Rocamora-Reverte et al.   Frontiers in Immunology

Immunoregulatory Cells in Myasthenia Gravis

(2021) Ying Wu et al.   Frontiers in Neurology

CD28null and Regulatory T Cells Are Substantially Disrupted in Patients with End-Stage Renal Disease Due to Diabetes Mellitus

(2021) Erasmia Sampani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulatory T cells in autoimmune hepatitis: an updated overview

(2021) Maria Serena Longhi et al.   JOURNAL OF AUTOIMMUNITY

Targeting Enclysis in Liver Autoimmunity, Transplantation, Viral Infection and Cancer

(2021) Yara O. Aghabi et al.   Frontiers in Immunology

Improving the Efficacy of Regulatory T Cell Therapy

(2021) Paulien Baeten et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Tissue Tregs

(2020) Prudence PokWai Lui et al.   IMMUNOLOGY

Immune modulation via T regulatory cell enhancement: disease‐modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases – An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)

(2020) F. Roth‐Walter et al.   ALLERGY

Role of regulatory T cells in psoriasis pathogenesis and treatment

(2020) L. Nussbaum et al.   BRITISH JOURNAL OF DERMATOLOGY

Treg Enhancing Therapies to Treat Autoimmune Diseases

(2020) Peter J. Eggenhuizen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of end stage renal disease on CD28 expression and T‐cell immunity

(2020) Erasmia Sampani et al.   NEPHROLOGY

The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

(2020) Lauren V. Terry et al.   Frontiers in Immunology

The role of Treg subtypes in glomerulonephritis

(2020) G. R. Herrnstadt et al.   CELL AND TISSUE RESEARCH

Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity?

(2020) Ibo Janssens et al.   CELLULAR IMMUNOLOGY

New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression

(2020) Norihisa Mikami et al.   CURRENT OPINION IN IMMUNOLOGY

A method for expansion and retroviral transduction of mouse regulatory T cells

(2020) Dan Wu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Infiltration of Immunoinflammatory Cells and Related Chemokine/Interleukin Expression in Different Gastric Immune Microenvironments

(2020) Ang Wang et al.   Journal of Immunology Research

Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis

(2020) Laura Elisa Buitrago-Molina et al.   JOURNAL OF AUTOIMMUNITY

T cells in primary Sjögren’s syndrome: targets for early intervention

(2019) Gwenny M Verstappen et al.   RHEUMATOLOGY

Correction of Defective T-Regulatory Cells From Patients With Crohn’s Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α

(2019) Rimma Goldberg et al.   GASTROENTEROLOGY

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

Current Clinical Trials in Pemphigus and Pemphigoid

(2019) Kentaro Izumi et al.   Frontiers in Immunology

Low Dose Interleukin-2 for Refractory Autoimmune Hepatitis

(2018) Tiong Y. Lim et al.   HEPATOLOGY

Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus

(2018) Masayuki Mizui et al.   Frontiers in Immunology

Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells

(2018) Marco Romano et al.   Frontiers in Immunology

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

(2018) Henrieta Fraser et al.   Molecular Therapy-Methods & Clinical Development

Regulatory T Cells for More Targeted Immunosuppressive Therapies

(2018) Hazim Allos et al.   CLINICS IN LABORATORY MEDICINE

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier

(2018) Jonathan H. Esensten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus

(2018) Maria Dall'Era et al.   Arthritis & Rheumatology

Regulatory T Cells in Systemic Sclerosis

(2018) Camelia Frantz et al.   Frontiers in Immunology

Analysis of FOXP3+ regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus

(2017) Angelika Schmidt et al.   IMMUNOLOGIC RESEARCH

Autoimmune hepatitis: From current knowledge and clinical practice to future research agenda

(2017) Marcial Sebode et al.   LIVER INTERNATIONAL

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris

(2016) Thomas Schmidt et al.   EXPERIMENTAL DERMATOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation

(2016) Niloufar Safinia et al.   Oncotarget

The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis

(2016) Takayoshi Morita et al.   PLoS One

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

(2015) I. E. Dijke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome

(2015) Sara Omenetti et al.   Frontiers in Immunology

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

Regulatory T cells in systemic lupus erythematosus

(2014) Kim Ohl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies

(2014) Richard Taubert et al.   JOURNAL OF HEPATOLOGY

Decreased expression of Runx1 and lowered proportion of Foxp3+ CD25+ CD4+ regulatory T cells in systemic sclerosis

(2014) Hiroshi Kataoka et al.   Modern Rheumatology

Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand

(2014) D Nazzal et al.   Cell Death & Disease

Challenges in cryopreservation of regulatory T cells (Tregs) for clinical therapeutic applications

(2013) Karolina Golab et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus

(2013) A. Toker et al.   JOURNAL OF IMMUNOLOGY

Natural and Induced T Regulatory Cells in Cancer

(2013) Dennis O. Adeegbe et al.   Frontiers in Immunology

Neutrophil – CD4+CD25+ T regulatory cell interactions: A possible new mechanism of infectious tolerance

(2012) Natalia Lewkowicz et al.   IMMUNOBIOLOGY

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T cells in autoimmune hepatitis

(2012) Maria Serena Longhi et al.   JOURNAL OF HEPATOLOGY

FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency

(2012) Moritz Peiseler et al.   JOURNAL OF HEPATOLOGY

Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

(2012) J. Gotot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris

(2011) T. Yokoyama et al.   INTERNATIONAL IMMUNOLOGY

Role of CD4+CD25high+FOXP3+Regulatory T Cells in Psoriasis

(2010) Woo-Jin Yun et al.   Annals of Dermatology

Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma

(2010) S. Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea

(2010) E. Antiga et al.   BRITISH JOURNAL OF DERMATOLOGY

Role of Treg in immune regulation of allergic diseases

(2010) Oscar Palomares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel role of regulatory T cells in limiting early neutrophil responses in skin

(2010) Hannah Richards et al.   IMMUNOLOGY

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

(2010) A. K. Marwaha et al.   JOURNAL OF IMMUNOLOGY

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

(2010) M. Feuerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells

(2010) H. Tsukamoto et al.   RHEUMATOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Increased Th17 cells are accompanied by FoxP3+ Treg cell accumulation and correlated with psoriasis disease severity

(2009) Li Zhang et al.   CLINICAL IMMUNOLOGY

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

(2009) N. Iikuni et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foxp3+ T-Regulatory Cells in Sjögren's Syndrome

(2008) Maria I. Christodoulou et al.   AMERICAN JOURNAL OF PATHOLOGY

CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis

(2008) Guang Ming Han et al.   CELLULAR IMMUNOLOGY

Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target

(2008) Dorothy K. Sojka et al.   IMMUNOLOGY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis

(2008) F. Flores-Borja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus

(2008) H.-Y. Lee et al.   RHEUMATOLOGY

Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis

(2007) M C Vonk et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjögren's syndrome

(2007) M.-F. Liu et al.   LUPUS