Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Immunology
Dandan Yang, Xueqiang Zhao, Xin Lin
Summary: Bcl10 plays a critical role in the development and function of regulatory T (Treg) cells, deficiency of which leads to impaired development and suppressive function of Treg cells, even causing lethal autoimmunity. Bcl10-deficient Treg cells can undergo conversion into proinflammatory cells and decrease in effector Treg cell populations. The study provides genetic evidence that Bcl10 is essential for Treg cell development and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Allergy
Matteo Doglio, Tobias Alexander, Nicoletta Del Papa, John A. Snowden, Raffaella Greco
Summary: Systemic lupus erythematous is a heterogeneous autoimmune disease with a complex etiopathogenesis. Cellular therapies, such as autologous hematopoietic stem cell transplantation and regulatory T-cell therapy, have shown potential for providing more specific and sustainable treatment options for this disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jonathan Charaix, Alexia Borelli, Jeremy C. Santamaria, Lionel Chasson, Matthieu Giraud, Arnauld Serge, Magali Irla
Summary: This study reveals that Aire regulates the suppressive signature of recirculating T-reg in the thymus. Specifically, Aire controls the suppressive function of recirculating T-reg by regulating the expression of mTEC, which are responsible for restimulating T-reg.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Review
Immunology
Arielle Raugh, Denise Allard, Maria Bettini
Summary: This review highlights the alterations in gene expression and function of regulatory T cells (Tregs) in autoimmune diseases. It discusses the potential impact of genetic, epigenetic, and environmental factors on Treg development and function. The review also explores the influence of the tissue microenvironment on Treg function, stability, and plasticity. Additionally, it provides insights into the current efficacy and future directions of Treg-based therapies for Type 1 Diabetes and other autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Zheng Zhang, Jihua Guo, Rong Jia
Summary: Treg plasticity is associated with inflammatory diseases and cancers. Regulating Treg plasticity is a promising direction for the treatment of inflammatory diseases and cancers.
INFLAMMATION RESEARCH
(2023)
Review
Immunology
David W. Scott
Summary: The use of CAR transduced T cells and engineered Tregs with specific receptors show great promise in cancer immunotherapy. Methods involving retroviral transduction of specific T-cell receptors, scFv, or antigens for various diseases models are discussed for their potential clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Review
Immunology
Sudhir Gupta, Yesim Demirdag, Ankmalika Abha Gupta
Summary: CD4 T regulatory cells play crucial roles in peripheral tolerance and the pathogenesis of autoimmune diseases in both human and experimental models. Other regulatory lymphocytes, such as CD8 Tregs, Bregs, and T-FR cells, are also important players in these processes. Their phenotypic characteristics and mechanisms of immunoregulation are still evolving, emphasizing the complexity of interplay among various regulatory lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Tracoyia Roach, Laurence Morel
Summary: Immune homeostasis relies on the balance between effector T cells and regulatory T cells. Studies have identified genetic factors that maintain the stability and suppressive function of regulatory T cells, which could potentially be targeted for therapeutic intervention against autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hardeep Singh Tuli, Vivek Kumar Garg, Sakshi Bhushan, Vivek Uttam, Uttam Sharma, Aklank Jain, Katrin Sak, Vikas Yadav, Jose M. Lorenzo, Kuldeep Dhama, Tapan Behl, Gautam Sethi
Summary: Cancer prevalence and incidence rates have been increasing over the past few decades. To combat this disease, it is necessary to explore safer and more effective molecules. Flavonoids, a class of polyphenols, have shown potential against cancer without significant toxicity to normal cells. They modulate microRNAs to enhance drug sensitivity and suppress cancer cell proliferation, metastasis, and angiogenesis. This review comprehensively discusses the structure, chemistry, and effects of flavonoids like quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, and cyanidin on various cancer types. Targeting miRNAs by flavonoids in cancer cells could be a promising approach for future clinical investigations and affirmation.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Kuldeep Dhama, Firzan Nainu, Andri Frediansyah, Mohd Iqbal Yatoo, Ranjan K. Mohapatra, Sandip Chakraborty, Hao Zhou, Md. Rabiul Islam, Sukamto S. Mamada, Hendrix Indra Kusuma, Ali A. Rabaan, Saad Alhumaid, Abbas Al Mutair, Muhammad Iqhrammullah, Jaffar A. Al-Tawfiq, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Hardeep Singh Tuli, Chiranjib Chakraborty, Harapan Harapan
Summary: Newly emerging variants of SARS-CoV-2 continuously pose global public health concerns and can lead to waves of COVID-19 pandemic. These variants can spread quickly across countries, cause severe disease and reduce the efficacy of current vaccines and immunotherapies. The Omicron variant, first identified in South Africa, is currently the only variant of interest. This review provides an overview of SARS-CoV-2 variants, with a focus on the Omicron variant, its lineages, and hybrid variants. The challenges and strategies to counter the Omicron variant amid the ongoing COVID-19 pandemic are also discussed.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Gulden Goksen, Didem Demir, Kuldeep Dhama, Manoj Kumar, Ping Shao, Fengwei Xie, Noemi Echegaray, Jose Manuel Lorenzo
Summary: Current trends favor the use of natural components for creating healthful, environmentally friendly, sustainable, and profitable goods. In response, the food industry is seeking safe natural ingredients to produce low-fat, artificial-additive-free, gluten-free, prebiotic, and fortified foods. Similarly, the pharmaceutical and medical industries are exploring the application of natural ingredients, specifically plant mucilage, to address biomaterial challenges more efficiently. Plant mucilage has proven to have excellent health features and technological properties, making it useful for both food and biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Letter
Surgery
Manish Dhawan, Manish Sharma, Talha B. Emran, Ali A. Rabaan
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Oroshay Kaiwan, Yashendra Sethi, Nimrat Khehra, Inderbir Padda, Hitesh Chopra, Deepak Chandran, Kuldeep Dhama, Chiranjib Chakraborty, Md. Aminul Islam, Nirja Kaka
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Ravinder Singh, Manjinder Singh, Varinder Singh, Pratima Kumari, Hitesh Chopra, Om Prakash Priyanka, Om Prakash B. Choudhary, Talha Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Chiranjib Chakraborty, Manojit Bhattacharya, Hitesh Chopra, Prosun Bhattacharya, Md. Aminul Islam, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Editorial Material
Microbiology
Md. Aminul Islam, Fatema Hasan Kaifa, Deepak Chandran, Manojit Bhattacharya, Chiranjib Chakraborty, Prosun Bhattacharya, Kuldeep Dhama
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Neurosciences
Kumaraswamy Gandla, Ancha Kishore Babu, Aziz Unnisa, Indu Sharma, Laliteshwar Pratap Singh, Mahammad Akiful Haque, Neelam Laxman Dashputre, Shahajan Baig, Falak A. Siddiqui, Mayeen Uddin Khandaker, Abdullah Almujally, Nissren Tamam, Abdelmoneim Sulieman, Sharuk L. Khan, Talha Bin Emran
Summary: Various factors, such as oxidative stress and the pathological state of neurodegenerative disorders (NDs), can contribute to their development. Carotenoids (CTs), natural pigments, have significant anti-inflammatory and antioxidant effects, and studies have found a strong correlation between CT levels in the body and the prevention and treatment of NDs.
Letter
Medicine, General & Internal
Md. Rezaul Islam, Showkat A. Mir, Shopnil Akash, Kuldeep Dhama
ANNALS OF MEDICINE AND SURGERY
(2023)
Review
Medicine, General & Internal
Kannan Raman, Kalirajan Rajagopal, B. Ramesh, P. Kumar Nallasivan, M. K. Mohan M. Raja, Srikanth Jupudi, Gowramma Byran, Sharuk L. Khan, Talha Bin Emran
Summary: The new coronavirus, which was discovered in late 2019, has caused widespread illness and death worldwide. Currently, there are no specific treatments available for this infection, leading to the use of natural products as potential antiviral medications and immunity boosters. However, not all natural compounds are effective against the virus.
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Orthopedics
Ranjit Sah, Mohammed Amir Rais, Aroop Mohanty, Hitesh Chopra, Deepak Chandran, Talha Bin Emran, Kuldeep Dhama
Summary: The highly contagious Omicron variant of SARS-CoV-2 has become a cause for concern during the ongoing COVID-19 pandemic. It is classified as a variant of concern by the World Health Organization (WHO) and has spread faster than any other variant since its emergence in late 2021. Omicron is currently the only circulating VOC and its subvariant BA.5 is the most contagious and dominant globally. This article emphasizes the importance of effective vaccination and adherence to preventive measures in curbing the transmission of these variants.
INTERNATIONAL JOURNAL OF SURGERY OPEN
(2023)
Article
Public, Environmental & Occupational Health
Rabab G. A. El-Kader, Rekha J. J. Ogale, Omar Omar Zidan, Omar Al Jadaan, Vijaya Kumardhas, Sirwan K. K. Ahmed, Kuldeep Dhama, S. Praveen, Mohammad Ebad Ur Rehman
Summary: This study assessed the health-related behaviors of university students in Ras Al Khaimah, United Arab Emirates. The findings revealed that over a quarter of participants were overweight and most students did not adhere to safety guidelines and nutritious eating. The study highlights significant health promotion opportunities for university students to foster a healthier youth.
HEALTH SCIENCE REPORTS
(2023)
Letter
Surgery
Hitesh Chopra, Kuldeep Dhama, Talha B. Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Chemistry, Multidisciplinary
Hitesh Chopra, Yugal Kishore Mohanta, Saurov Mahanta, Tapan Kumar Mohanta, Inderbir Singh, Satya Kumar Avula, Sarada Prasanna Mallick, Ali A. Rabaan, Hajir Alsaihati, Ahmed Alsayyah, Mohammed Alissa, Hussain R. Alturaifi, Bader Alalwan, Mohamed S. Attia, Sandip Chakraborty, Kuldeep Dhama
Summary: This article introduces the methods and applications of using nanotechnology to promote wound healing. Nanomaterials can alter the wound microenvironment through antibacterial, anti-inflammatory, and angiogenic actions to accelerate wound healing.
NANOTECHNOLOGY REVIEWS
(2023)
