Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection

Inhibition of sphingosine‐1‐phosphate‐induced Th17 cells ameliorates alcoholic steatohepatitis in mice

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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

(2020) Judith Lang et al.   Nature Communications

Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA + B Cells

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Interleukin 21 collaborates with interferon-γ for the optimal expression of interferon-stimulated genes and enhances protection against enteric microbial infection

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Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis

(2019) Jana Meiners et al.   Frontiers in Immunology

Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

(2019) P. Kent Langston et al.   NATURE IMMUNOLOGY

Citrobacter rodentium–host–microbiota interactions: immunity, bioenergetics and metabolism

(2019) Caroline Mullineaux-Sanders et al.   NATURE REVIEWS MICROBIOLOGY

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

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Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens

(2017) Yun-Gi Kim et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

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Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation

(2017) Nazanin Navabi et al.   Cell Reports

IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection

(2016) Tamas Dolowschiak et al.   Cell Host & Microbe

Intrinsic Defense Mechanisms of the Intestinal Epithelium

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Milk sphingomyelin improves lipid metabolism and alters gut microbiota in high fat diet-fed mice

(2016) Gregory H. Norris et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Citrobacter rodentium -induced colitis: A robust model to study mucosal immune responses in the gut

(2015) Ekaterina P. Koroleva et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis

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mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Regulation of PP2A by Sphingolipid Metabolism and Signaling

(2015) Joshua Oaks et al.   Frontiers in Oncology

Pathogens’ Exploitation of the Intestinal Food Web

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Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Intestinal monocytes and macrophages are required for T cell polarization in response toCitrobacter rodentium

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

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Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

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Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

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The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

(2011) Kaoru Geddes et al.   NATURE MEDICINE

Sphingosine Interaction with Acidic Leucine-rich Nuclear Phosphoprotein-32A (ANP32A) Regulates PP2A Activity and Cyclooxygenase (COX)-2 Expression in Human Endothelial Cells

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Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis

(2010) M. A. Ciorba et al.   JOURNAL OF IMMUNOLOGY

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development

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