Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis

(2021) Maryam Aftabizadeh et al.   JCI Insight

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

(2020) Jessica C. Casciano et al.   BRITISH JOURNAL OF CANCER

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells

(2020) Emily Clement et al.   EMBO JOURNAL

Acetate promotes SNAI1 expression by ACSS2-mediated histone acetylation under glucose limitation in renal cell carcinoma cell

(2020) Lv Yao et al.   BIOSCIENCE REPORTS

Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine

(2020) Sas N. Dijk et al.   Scientific Reports

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses

(2020) Ryan Houston et al.   PLOS BIOLOGY

MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer

(2019) Wanming He et al.   ONCOGENE

Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation

(2019) Ceren Duman et al.   Cell Metabolism

Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer

(2019) Songtao Cheng et al.   CLINICAL SCIENCE

Adipocyte and lipid metabolism in cancer drug resistance

(2019) Yihai Cao   JOURNAL OF CLINICAL INVESTIGATION

A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors

(2019) Andrea Aloia et al.   CLINICAL CANCER RESEARCH

Solute carrier transporters: the metabolic gatekeepers of immune cells

(2019) Wenxin Song et al.   Acta Pharmaceutica Sinica B

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction

(2018) Elizabeth A. Killion et al.   Molecular Metabolism

Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture

(2018) Matthew Redmann et al.   Redox Biology

Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans

(2017) Mittal J. Jasoliya et al.   HUMAN MOLECULAR GENETICS

JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework

(2017) Aziz Khan et al.   NUCLEIC ACIDS RESEARCH

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

(2017) Heather J. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

(2016) Mahesh S. Padanad et al.   Cell Reports

STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism

(2016) Yan S. Xu et al.   Scientific Reports

Retention Time Prediction Improves Identification in Nontargeted Lipidomics Approaches

(2015) Fabian Aicheler et al.   ANALYTICAL CHEMISTRY

PPARδ activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro

(2015) Chin Fung Kelvin Kan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Erratum to: Mitochondrial phospholipids: role in mitochondrial function

(2015) Edgard M. Mejia et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

ACSL4 promotes prostate cancer growth, invasion and hormonal resistance

(2015) Xinyu Wu et al.   Oncotarget

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation

(2014) Olga Pougovkina et al.   HUMAN MOLECULAR GENETICS

c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate

(2014) Lia R. Edmunds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Phospholipid Metabolites in Recurrent Glioblastoma: In Vivo Markers Detect Different Tumor Phenotypes before and under Antiangiogenic Therapy

(2013) Elke Hattingen et al.   PLoS One

Cytochrome c causes pore formation in cardiolipin-containing membranes

(2013) C. L. Bergstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Increased Expression of Phosphatidylcholine (16:0/18:1) and (16:0/18:2) in Thyroid Papillary Cancer

(2012) Seiji Ishikawa et al.   PLoS One

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation

(2012) H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry

(2012) A Perelman et al.   Cell Death & Disease

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

(2010) Paula M. Maloberti et al.   PLoS One

Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand: Figure 1.

(2009) Vishal M. Gohil et al.   JOURNAL OF CELL BIOLOGY