Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins

Dementia with Lewy bodies—associated ß-synuclein mutations V70M and P123H cause mutation-specific neuropathological lesions

(2021) Maryna Psol et al.   HUMAN MOLECULAR GENETICS

β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins

(2021) Natalia Ninkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein

(2020) Masayo Fujita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice

(2020) Natalia Ninkina et al.   NEUROBIOLOGY OF AGING

Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation

(2020) Karan Sharma et al.   ACS Chemical Neuroscience

Hidden proteome of synaptic vesicles in the mammalian brain

(2020) Zacharie Taoufiq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synapsins regulate α-synuclein functions

(2019) Merav Atias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

(2019) Jichao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic vesicle mimics affect the aggregation of wild-type and A53T α-synuclein variants differently albeit similar membrane affinity

(2019) Sandra Rocha et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Comparative Analysis of the Conformation, Aggregation, Interaction, and Fibril Morphologies of Human α-, β-, and γ-Synuclein Proteins

(2018) Manish Kumar Jain et al.   BIOCHEMISTRY

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

(2018) Matthew J. Benskey et al.   Frontiers in Molecular Neuroscience

Vibrational circular dichroism sheds new light on the competitive effects of crowding and β-synuclein on the fibrillation process of α-synuclein

(2018) Evelien Van de Vondel et al.   BIOCHEMISTRY

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

(2017) Ulf Dettmer et al.   HUMAN MOLECULAR GENETICS

Synucleins Have Multiple Effects on Presynaptic Architecture

(2017) Karina J. Vargas et al.   Cell Reports

Potential of mean force and molecular dynamics study on the transient interactions between α and β synuclein that drive inhibition of α-synuclein aggregation

(2016) Airy Sanjeev et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Combinational losses of synucleins reveal their differential requirements for compensating age-dependent alterations in motor behavior and dopamine metabolism

(2016) Natalie Connor-Robson et al.   NEUROBIOLOGY OF AGING

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

(2016) Timothy J. Collier et al.   Frontiers in Neuroscience

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

(2016) James W. P. Brown et al.   Scientific Reports

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein

(2015) Maria K. Janowska et al.   Scientific Reports

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?

(2014) Katerina Markopoulou et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

(2013) Grit Taschenberger et al.   ANNALS OF NEUROLOGY

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses

(2012) Natalia Ninkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying Interactions of β-Synuclein and γ-Synuclein with Model Membranes

(2012) Vanessa C. Ducas et al.   JOURNAL OF MOLECULAR BIOLOGY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Systematic Mutagenesis of  -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities

(2012) J. Burre et al.   JOURNAL OF NEUROSCIENCE

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis

(2012) Owen M. Peters et al.   NEUROBIOLOGY OF DISEASE

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

(2011) Manu Sharma et al.   EMBO JOURNAL

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma

(2011) J. V. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of α-, β-, and γ-Synuclein With Diffuse Lewy Body Disease

(2010) Kenya Nishioka et al.   ARCHIVES OF NEUROLOGY

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Role of gamma-synuclein in microtubule regulation

(2010) Hong Zhang et al.   EXPERIMENTAL CELL RESEARCH

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

(2010) Oleg S Gorbatyuk et al.   MOLECULAR THERAPY

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

(2010) Manu Sharma et al.   NATURE CELL BIOLOGY

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Expansion of the Parkinson disease-associated SNCA- Rep1 allele upregulates human α-synuclein in transgenic mouse brain

(2009) Kenneth D. Cronin et al.   HUMAN MOLECULAR GENETICS

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

(2009) Natalia Ninkina et al.   HUMAN MOLECULAR GENETICS

Effect of Pseudorepeat Rearrangement on α-Synuclein Misfolding, Vesicle Binding, and Micelle Binding

(2009) Jampani Nageswara Rao et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic Regulation of α-Synuclein mRNA Expression in Various Human Brain Tissues

(2009) Colton Linnertz et al.   PLoS One

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

(2008) Steven L. Senior et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

(2008) Abdelmojib Al-Wandi et al.   NEUROBIOLOGY OF AGING

Desipramine Modulation of α-, γ-Synuclein and the Norepinephrine Transporter in an Animal Model of Depression

(2008) Alexis M Jeannotte et al.   NEUROPSYCHOPHARMACOLOGY

Molecular determinants of the aggregation behavior of α- and β-synuclein

(2008) Robert C. Rivers et al.   PROTEIN SCIENCE