Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers

An extended APOBEC3A mutation signature in cancer

(2021) Adam Langenbucher et al.   Nature Communications

DNA molecular combing-based replication fork directionality profiling

(2021) Marion Blin et al.   NUCLEIC ACIDS RESEARCH

Pan-cancer analysis of whole genomes

(2020)   NATURE

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

(2020) Yi-Ju Chen et al.   CELL

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

(2020) David Mas-Ponte et al.   NATURE GENETICS

Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

(2020) Pégah Jalili et al.   Nature Communications

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

(2020) Emily K. Law et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

(2020) Ming-Jun Shi et al.   Genome Medicine

APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer

(2019) Ming-Jun Shi et al.   EUROPEAN UROLOGY

Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features

(2019) Rémi Buisson et al.   SCIENCE

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

(2019) Abby M. Green et al.   DNA REPAIR

APOBEC3A is a prominent cytidine deaminase in breast cancer

(2019) Luis M. Cortez et al.   PLoS Genetics

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins

(2017) Fumiaki Ito et al.   JOURNAL OF MOLECULAR BIOLOGY

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

(2017) Yi Kan Wang et al.   NATURE GENETICS

APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks

(2017) Liqun Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA

(2017) Emily K. Schutsky et al.   NUCLEIC ACIDS RESEARCH

APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism

(2017) Ting-Wen Chen et al.   Nature Communications

APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks

(2017) Liqun Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells

(2017) Sebastian Pott   eLife

Understanding mutagenesis through delineation of mutational signatures in human cancer

(2016) Mia Petljak et al.   CARCINOGENESIS

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

APOBEC3A damages the cellular genome during DNA replication

(2016) Abby M. Green et al.   CELL CYCLE

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

(2016) Vladimir B. Seplyarskiy et al.   GENOME RESEARCH

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

(2016) J Zámborszky et al.   ONCOGENE

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B

(2016) Monica K. Akre et al.   PLoS One

Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations inEscherichia coli

(2016) Ashok S. Bhagwat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The topography of mutational processes in breast cancer genomes

(2016) Sandro Morganella et al.   Nature Communications

Replication landscape of the human genome

(2016) Nataliya Petryk et al.   Nature Communications

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

(2016) Igor B. Rogozin et al.   Scientific Reports

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

(2016) James I. Hoopes et al.   Cell Reports

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions

(2015) Marat D. Kazanov et al.   Cell Reports

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

(2014) Stephen Henderson et al.   Cell Reports

APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma

(2013) B. Leonard et al.   CANCER RESEARCH

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

Chromosome Engineering Allows the Efficient Isolation of Vertebrate Neocentromeres

(2013) Wei-Hao Shang et al.   DEVELOPMENTAL CELL

The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis

(2013) Kin Chan et al.   DNA REPAIR

The AID-Induced DNA Damage Response in Chromatin

(2013) Jeremy A. Daniel et al.   MOLECULAR CELL

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Efficient Deamination of 5-Methylcytidine and 5-Substituted Cytidine Residues in DNA by Human APOBEC3A Cytidine Deaminase

(2013) Rodolphe Suspène et al.   PLoS One

Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death

(2013) Bianka Mussil et al.   PLoS One

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

(2013) Benjamin JM Taylor et al.   eLife

Creative deaminases, self-inflicted damage, and genome evolution

(2012) Silvestro G. Conticello   Annals of the New York Academy of Sciences

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A

(2012) Michael A. Carpenter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Analysis of Hypermutation by the Deoxycytidine Deaminase APOBEC3A

(2012) Robin P. Love et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G

(2012) Priyanga Wijesinghe et al.   NUCLEIC ACIDS RESEARCH

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

(2011) Sébastien Landry et al.   EMBO REPORTS

Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine Deaminase

(2009) Iñigo Narvaiza et al.   PLoS Pathogens