Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients
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Title
Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients
Authors
Keywords
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Journal
Stem Cell Research & Therapy
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-06-03
DOI
10.1186/s13287-022-02901-4
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Note: Only part of the references are listed.- Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
- (2022) Lei Zhang et al. FEBS Journal
- Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
- (2021) Kangkang Zha et al. npj Regenerative Medicine
- Chronological Age Affects MSC Senescence In Vitro—A Systematic Review
- (2021) Konstantinos Kapetanos et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees
- (2021) Ichiro Sekiya et al. Scientific Reports
- Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development
- (2020) Junjie Huang et al. STEM CELLS AND DEVELOPMENT
- Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis
- (2020) Hao Yang et al. Aging-US
- Senolytic drugs: from discovery to translation
- (2020) J. L. Kirkland et al. JOURNAL OF INTERNAL MEDICINE
- Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells
- (2019) Alessandro Bertolo et al. Scientific Reports
- MSC Therapy for Osteoarthritis: An Unfinished Story
- (2019) Frank Barry JOURNAL OF ORTHOPAEDIC RESEARCH
- Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs
- (2019) María Satué et al. Scientific Reports
- Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
- (2019) Manuel J. Del Rey et al. Immunity & Ageing
- Senescent cells and osteoarthritis: a painful connection
- (2018) Ok Hee Jeon et al. JOURNAL OF CLINICAL INVESTIGATION
- Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
- (2018) Fumitaka Mizoguchi et al. Nature Communications
- Effects of senolytic drugs on human mesenchymal stromal cells
- (2018) Clara Grezella et al. Stem Cell Research & Therapy
- To stay young, kill zombie cells
- (2017) Megan Scudellari NATURE
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats
- (2016) N. Ozeki et al. OSTEOARTHRITIS AND CARTILAGE
- In vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model
- (2016) Meng Li et al. Stem Cell Research & Therapy
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Combination therapy with intra-articular injection of mesenchymal stem cells and articulated joint distraction for repair of a chronic osteochondral defect in the rabbit
- (2015) Yohei Harada et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Diagnosis and Treatment of Osteoarthritis
- (2013) Rafaelani L. Taruc-Uy et al. PRIMARY CARE
- Prospective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency
- (2013) Francesca Gullo et al. RHEUMATOLOGY
- Implantation of Allogenic Synovial Stem Cells Promotes Meniscal Regeneration in a Rabbit Meniscal Defect Model
- (2012) Masafumi Horie et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
- (2010) Jérémie Sellam et al. Nature Reviews Rheumatology
- Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit
- (2008) Hideyuki Koga et al. CELL AND TISSUE RESEARCH
- Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
- (2008) Paolo Bianco et al. Cell Stem Cell
- Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
- (2008) Wolfgang Wagner et al. PLoS One
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