Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion

(Z)-2-(2-Bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An Orally Bioavailable PPARβ/δ-Selective Ligand with Inverse Agonistic Properties

(2012) Sonja Lieber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging Roles of Angiopoietin-like 4 in Human Cancer

(2012) Ming Jie Tan et al.   MOLECULAR CANCER RESEARCH

Gene Expression Patterns Related to Vascular Invasion and Aggressive Features in Endometrial Cancer

(2011) Monica Mannelqvist et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin-like 4: a decade of research

(2011) Pengcheng Zhu et al.   BIOSCIENCE REPORTS

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

(2011) R.-L. Huang et al.   BLOOD

Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2−:H2O2 Ratio and Confers Anoikis Resistance to Tumors

(2011) Pengcheng Zhu et al.   CANCER CELL

Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes

(2011) Michael G. Borland et al.   CELLULAR SIGNALLING

Development of Improved PPARβ/δ Inhibitors

(2011) Philipp M. Toth et al.   ChemMedChem

Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin β1 signaling in human hepatocellular carcinoma

(2011) Hong Li et al.   HEPATOLOGY

Proteolytic Processing of Angiopoietin-like Protein 4 by Proprotein Convertases Modulates Its Inhibitory Effects on Lipoprotein Lipase Activity

(2011) Xia Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis

(2011) Nakayama   ONCOLOGY REPORTS

Genomewide Analyses Define Different Modes of Transcriptional Regulation by Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ)

(2011) Till Adhikary et al.   PLoS One

New insights into the role of PPARs

(2011) Alexandra Montagner et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Angiopoietin-Like 4 Interacts with Integrins β1 and β5 to Modulate Keratinocyte Migration

(2010) Yan Yih Goh et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin-like 4 Interacts with Matrix Proteins to Modulate Wound Healing

(2010) Yan Yih Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Profiling Identifies Functional Interactions of TGFβ and PPARβ/δ Signaling

(2010) Kerstin Kaddatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

(2010) Barry G. Shearer et al.   JOURNAL OF MEDICINAL CHEMISTRY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling

(2010) Josefine Stockert et al.   NUCLEIC ACIDS RESEARCH

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion

(2010) Nakayama   ONCOLOGY REPORTS

Determination of Angptl4 mRNA as a Diagnostic Marker of Primary and Metastatic Clear Cell Renal-Cell Carcinoma

(2010) Jérôme Verine et al.   PLoS One

Lysophosphatidic Acid Induces MDA-MB-231 Breast Cancer Cells Migration through Activation of PI3K/PAK1/ERK Signaling

(2010) Jun Du et al.   PLoS One

A compact VEGF signature associated with distant metastases and poor outcomes

(2009) Zhiyuan Hu et al.   BMC Medicine

Activating Peroxisome Proliferator-Activated Receptor   Mutant Promotes Tumor Growth In vivo by Enhancing Angiogenesis

(2009) L. Tian et al.   CANCER RESEARCH

Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism

(2009) Suneil K. Koliwad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production

(2008) Olga Gealekman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Suppression of the Raf/MEK/ERK Signaling Cascade and Inhibition of Angiogenesis by the Carboxyl Terminus of Angiopoietin-Like Protein 4

(2008) Ying-Hua Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PPARδ agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle

(2008) Hyun-Joung Lim et al.   ATHEROSCLEROSIS

Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells

(2008) Zhiyong Zhang et al.   CANCER LETTERS

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Ligand-Mediated Regulation of Peroxisome Proliferator-Activated Receptor (PPAR)  / : A Comparative Analysis of PPAR-Selective Agonists and All-trans Retinoic Acid

(2008) M. Rieck et al.   MOLECULAR PHARMACOLOGY

Macrophages, PPARs, and Cancer

(2008) Jo A. Van Ginderachter et al.   PPAR Research