Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma

Anatomic position determines oncogenic specificity in melanoma

(2022) Joshua M. Weiss et al.   NATURE

Exercise-induced myokines and their effect on prostate cancer

(2021) Jin-Soo Kim et al.   Nature Reviews Urology

Pan-cancer analysis of whole genomes

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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Anti-PD1 checkpoint inhibitor therapy in acral melanoma: a multicenter study of 193 Japanese patients

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Nuclear Membrane Rupture and Its Consequences

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Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma

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Repair of nuclear ruptures requires barrier-to-autointegration factor

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Nuclear envelope deformation controls cell cycle progression in response to mechanical force

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MK5 Regulates YAP Stability and Is a Molecular Target in YAP-Driven Cancers

(2019) Jimyung Seo et al.   CANCER RESEARCH

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Cycling, and Male Sexual and Urinary Function: Results from a Large, Multinational, Cross-Sectional Study

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Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction

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Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures

(2018) Natalie Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb

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cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Whole-genome landscapes of major melanoma subtypes

(2017) Nicholas K. Hayward et al.   NATURE

Mechanobiology of YAP and TAZ in physiology and disease

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Acral Melanoma and Mechanical Stress on the Plantar Surface of the Foot

(2017) Collin M. Costello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Causes and consequences of nuclear envelope alterations in tumour progression

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Mechanisms of Hippo pathway regulation

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Nuclear envelope rupture is induced by actin-based nucleus confinement

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Nuclear envelope rupture drives genome instability in cancer

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Melanomas and Mechanical Stress Points on the Plantar Surface of the Foot

(2016) Akane Minagawa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward a Shared Vision for Cancer Genomic Data

(2016) Robert L. Grossman et al.   NEW ENGLAND JOURNAL OF MEDICINE

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

(2015) M. H. Kim et al.   EMBO JOURNAL

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

(2014) Hong Sun Jang et al.   Annals of Dermatology

KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model

(2014) Junli Du et al.   Molecular BioSystems

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

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(2012) Jesse D. Vargas et al.   Nucleus

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

TEAD mediates YAP-dependent gene induction and growth control

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