Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury

Size matters: TLR4-mediated effects of α-(1,5)-linear arabino-oligosaccharides in macrophage-like cells depend on their degree of polymerization

(2021) Victor Costa Castro-Alves et al.   FOOD RESEARCH INTERNATIONAL

Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

(2021) Shalaka Wahane et al.   Science Advances

Current tools to interrogate microglial biology

(2021) Anaelle Aurelie Dumas et al.   NEURON

RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury

(2021) Sina Stern et al.   NEURON

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

(2020) Xiang Zhou et al.   NATURE NEUROSCIENCE

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation

(2020) Helena Crijns et al.   Frontiers in Immunology

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination

(2020) Annie Pu et al.   Journal of Neuroinflammation

Neuroimmune System as a Driving Force for Plasticity Following CNS Injury

(2020) Micaela L. O’Reilly et al.   Frontiers in Cellular Neuroscience

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

(2020) Anna Ciesielska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microglia-organized scar-free spinal cord repair in neonatal mice

(2020) Yi Li et al.   NATURE

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

(2020) Tobias Zrzavy et al.   BRAIN

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

(2020) Di Wu et al.   Nature Communications

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

Recent advances in the therapeutic uses of chondroitinase ABC

(2019) E. Muir et al.   EXPERIMENTAL NEUROLOGY

The translational landscape in spinal cord injury: focus on neuroplasticity and regeneration

(2019) Thomas H. Hutson et al.   Nature Reviews Neurology

Moving beyond the glial scar for spinal cord repair

(2019) Elizabeth J. Bradbury et al.   Nature Communications

The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan

(2018) Angela Avenoso et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis

(2018) Erin L Stephenson et al.   BRAIN

OUP accepted manuscript

(2018)   BRAIN

Emerging targets for reprograming the immune response to promote repair and recovery of function after spinal cord injury

(2018) Faith H. Brennan et al.   CURRENT OPINION IN NEUROLOGY

Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

(2018) Scott Dyck et al.   Journal of Neuroinflammation

Modulation of receptor protein tyrosine phosphatase sigma increases chondroitin sulfate proteoglycan degradation through Cathepsin B secretion to enhance axon outgrowth

(2018) Amanda Phuong Tran et al.   JOURNAL OF NEUROSCIENCE

Role of proteoglycans in neuro-inflammation and central nervous system fibrosis

(2018) Femke Heindryckx et al.   MATRIX BIOLOGY

The Biology of Regeneration Failure and Success After Spinal Cord Injury

(2018) Amanda Phuong Tran et al.   PHYSIOLOGICAL REVIEWS

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

(2018) Jordan R. Warford et al.   Acta Neuropathologica Communications

Anti-Chondroitin Sulfate Proteoglycan Strategies in Spinal Cord Injury: Temporal and Spatial Considerations Explain the Balance between Neuroplasticity and Neuroprotection

(2018) Todd Hryciw et al.   JOURNAL OF NEUROTRAUMA

Rapid and robust restoration of breathing long after spinal cord injury

(2018) Philippa M. Warren et al.   Nature Communications

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

How and why do T cells and their derived cytokines affect the injured and healthy brain?

(2017) Anthony J. Filiano et al.   NATURE REVIEWS NEUROSCIENCE

Traumatic spinal cord injury

(2017) Christopher S. Ahuja et al.   Nature Reviews Disease Primers

Chondroitin sulfate proteoglycans: Key modulators in the developing and pathologic central nervous system

(2015) Scott M. Dyck et al.   EXPERIMENTAL NEUROLOGY

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

(2015) Nicholas D. James et al.   EXPERIMENTAL NEUROLOGY

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

(2015) James T. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The resolution of inflammation: Principles and challenges

(2015) Sarah E. Headland et al.   SEMINARS IN IMMUNOLOGY

Monocyte subsets in man and other species

(2014) Loems Ziegler-Heitbrock   CELLULAR IMMUNOLOGY

Extracellular matrix regulation of inflammation in the healthy and injured spinal cord

(2014) Andrew D. Gaudet et al.   EXPERIMENTAL NEUROLOGY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Regulation of IL-10 by Chondroitinase ABC Promotes a Distinct Immune Response following Spinal Cord Injury

(2014) Athanasios Didangelos et al.   JOURNAL OF NEUROSCIENCE

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

(2014) K. Bartus et al.   JOURNAL OF NEUROSCIENCE

Neurite-J: An Image-J plug-in for axonal growth analysis in organotypic cultures

(2014) A. Torres-Espín et al.   JOURNAL OF NEUROSCIENCE METHODS

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Alternatively-Spliced Extra Domain A of Fibronectin Promotes Acute Inflammation and Brain Injury After Cerebral Ischemia in Mice

(2012) Mohammad Moshahid Khan et al.   STROKE

Non-Resolving Aspects of Acute Inflammation after Spinal Cord Injury (SCI): Indices and Resolution Plateau

(2011) Harald Prüss et al.   BRAIN PATHOLOGY

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

(2011) Rong-Rong Zhao et al.   JOURNAL OF NEUROSCIENCE METHODS

Functional regeneration of respiratory pathways after spinal cord injury

(2011) Warren J. Alilain et al.   NATURE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Emerging Concepts in Myeloid Cell Biology after Spinal Cord Injury

(2011) Alicia L. Hawthorne et al.   Neurotherapeutics

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells

(2009) Elizabeth M. Muir et al.   JOURNAL OF BIOTECHNOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation

(2009) Guillermo García-Alías et al.   NATURE NEUROSCIENCE

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

Expression of TLR4 and CD14 in the Central Nervous System (CNS) in a MPTP Mouse Model of Parkinson's-Like Disease

(2008) Maria Antonietta Panaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Can the immune system be harnessed to repair the CNS?

(2008) Phillip G. Popovich et al.   NATURE REVIEWS NEUROSCIENCE

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

(2008) L. Cao et al.   NEUROSCIENCE