Journal
FOOD RESEARCH INTERNATIONAL
Volume 141, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2020.110093
Keywords
Arabinans; Cytokines; Chemokines; Dietary fibre; Oligosaccharides
Categories
Funding
- Sao Paulo Research Foundation (FAPESP, Brazil) [2013/07914-8]
- Coordination for the Improvement of Higher Education Personnel (CAPES) [001]
- National Council for Scientific and Technological Development (CNPq)
- [310511/2018-6]
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The study found that controlled enzymatic hydrolysis of sugar beet arabinans can lead to the production of LAOS that interact with immune system cells, with the degree of polymerization (DP) influencing their biological effects. LAOS with higher DP mainly induce stimulatory effects through the TLR4/MyD88 pathway, while LAOS with lower DP have opposite effects and inhibit TLR4-mediated effects induced by both lipopolysaccharide and LAOS with higher DP.
Linear arabino-oligosaccharides (LAOS) produced from controlled enzymatic hydrolysis of arabinans from sugar beet are well-known because of their chain-length dependent prebiotic effects. However, it is not clear if these alpha-(1,5)-linked arabinose oligosaccharides can interact directly with immune system cells, as well as if its degree of polymerization (DP) influences possible biological effects. Four high purity LAOS with distinct DP were tested in macrophage-like cells exposed or not to LPS. Results shown that LAOS interact with Toll-like receptor (TLR) 4 in a chain length-dependent manner. LAOS with higher DP induce stimulatory effects mainly through the TLR4/ MyD88 pathway, thereby enhancing the release of tumor necrosis factor alpha (TNF-alpha), interleukin (IL-) 1 beta, 6, 12, and chemokines including MCP-1, RANTES, IL-8, and IP-10. Notably, LAOS with lower DP appears to have an opposite effect to those counterparts with higher DP, as they does not induce the secretion of cytokines and chemokines in macrophages-like cells, while also inhibit TLR4-mediated effects induced by both lipopolysaccharide and LAOS with higher DP. These findings provide not only insights into potential biological effects of LAOS, but also reveal that controlled enzymatic hydrolysis of sugar beet arabinans may lead to dietary oligosaccharides with desired biological properties.
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