SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions

SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4

(2021) Fanny Onodi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Toll‐like receptors in the pathogenesis of COVID‐19

(2021) Shaghayegh Khanmohammadi et al.   JOURNAL OF MEDICAL VIROLOGY

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

(2021) Antoine Rebendenne et al.   JOURNAL OF VIROLOGY

Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup

(2021) Eric J. Rubin et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

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Type I and III interferon responses in SARS-CoV-2 infection

(2021) You-Me Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Innate immune sensing of coronavirus and viral evasion strategies

(2021) Yusuke Kasuga et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

(2021) Min Zheng et al.   NATURE IMMUNOLOGY

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

(2021) L. Vanderbeke et al.   Nature Communications

Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells

(2021) Claire Cenac et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

HIV-1 Tat – TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway

(2020) Elmostafa Bahraoui et al.   Scientific Reports

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

Reappearance of effector T cells is associated with recovery from COVID-19

(2020) Ivan Odak et al.   EBioMedicine

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Human NLRP1 is a sensor for double-stranded RNA

(2020) Stefan Bauernfried et al.   SCIENCE

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

(2020) Tapas Patra et al.   PLoS Pathogens

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Toll-like receptor 4 in acute viral infection: Too much of a good thing

(2018) Judith Olejnik et al.   PLoS Pathogens

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production

(2017) Manutea Serrero et al.   Scientific Reports

SARS-CoV and IFN: Too Little, Too Late

(2016) Eveline Kindler et al.   Cell Host & Microbe

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

(2016) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Coronavirus envelope (E) protein remains at the site of assembly

(2015) Pavithra Venkatagopalan et al.   VIROLOGY

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms

(2014) R. Planes et al.   JOURNAL OF VIROLOGY

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

(2014) Marta L. DeDiego et al.   VIRUS RESEARCH

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 Tat Protein Induces the Production of IDO in Human Monocyte Derived-Dendritic Cells through a Direct Mechanism: Effect on T Cells Proliferation

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HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10

(2013) Nawal Ben Haij et al.   Retrovirology

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

(2010) Jason Netland et al.   VIROLOGY

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

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CHOP Transcription Factor Mediates IL-8 Signaling in Cystic Fibrosis Bronchial Epithelial Cells

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