Molecular farming using transgenic rice endosperm

Metabolic engineering of rice endosperm towards higher vitamin B1 accumulation

(2021) Simon Strobbe et al.   PLANT BIOTECHNOLOGY JOURNAL

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

(2021) Brian J. Ward et al.   NATURE MEDICINE

Riboflavin fortification of rice endosperm by metabolic engineering

(2021) Yong‐Sheng Tian et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-made vaccines and therapeutics

(2021) Hugues Fausther-Bovendo et al.   SCIENCE

Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial

(2021) Yoshikazu Yuki et al.   Lancet Microbe

Shortened snRNA promoters for efficient CRISPR/Cas-based multiplex genome editing in monocot plants

(2020) Yu Hao et al.   Science China-Life Sciences

Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides

(2020) Dandan Qian et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhancement of vitamin B 6 levels in rice expressing Arabidopsis vitamin B 6 biosynthesis de novo genes

(2019) Nathalie Mangel et al.   PLANT JOURNAL

Metabolic engineering of rice endosperm for betanin biosynthesis

(2019) Yong‐Sheng Tian et al.   NEW PHYTOLOGIST

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

(2018) Evangelia Vamvaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Golden Rice to aSTARice: Bioengineering Astaxanthin Biosynthesis in Rice Endosperm

(2018) Qinlong Zhu et al.   Molecular Plant

Enhancing carotenoid biosynthesis in rice endosperm by metabolic engineering

(2018) Yong-Sheng Tian et al.   PLANT BIOTECHNOLOGY JOURNAL

Stepwise pathway engineering to the biosynthesis of zeaxanthin, astaxanthin and capsanthin in rice endosperm

(2018) Sun-Hwa Ha et al.   METABOLIC ENGINEERING

Contribution of individual phenolics to antioxidant activity and in vitro digestibility of wild rices ( Zizania aquatica L.)

(2017) Daniela Sumczynski et al.   FOOD CHEMISTRY

Development of “Purple Endosperm Rice” by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System

(2017) Qinlong Zhu et al.   Molecular Plant

An overview on the strategies to exploit rice endosperm as production platform for biopharmaceuticals

(2017) Fumio Takaiwa et al.   PLANT SCIENCE

Production and characterization of recombinant human acid α-glucosidase in transgenic rice cell suspension culture

(2016) Jae-Wan Jung et al.   JOURNAL OF BIOTECHNOLOGY

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV

(2016) Evangelia Vamvaka et al.   PLANT BIOTECHNOLOGY JOURNAL

Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity

(2016) Chao Bai et al.   TRANSGENIC RESEARCH

Opportunities for Products of New Plant Breeding Techniques

(2016) Jan G. Schaart et al.   TRENDS IN PLANT SCIENCE

Comparison on cellular mechanisms of iron and cadmium accumulation in rice: prospects for cultivating Fe-rich but Cd-free rice

(2016) Lei Gao et al.   Rice

Biofortified indica rice attains iron and zinc nutrition dietary targets in the field

(2016) Kurniawan R. Trijatmiko et al.   Scientific Reports

Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds

(2015) Jesse G. Zalatan et al.   CELL

Optimisation and validation of the microwave-assisted extraction of phenolic compounds from rice grains

(2015) W. Setyaningsih et al.   FOOD CHEMISTRY

A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants

(2015) Xingliang Ma et al.   Molecular Plant

Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering

(2015) Dieter Blancquaert et al.   NATURE BIOTECHNOLOGY

Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12

(2015) Evangelia Vamvaka et al.   PLANT BIOTECHNOLOGY JOURNAL

Antihypertensive Peptides from Food Proteins

(2015) Rotimi E. Aluko   Annual Review of Food Science and Technology

Transgenic rice endosperm as a bioreactor for molecular pharming

(2014) Jiquan Ou et al.   PLANT CELL REPORTS

Over-expression of the MxIRT1 gene increases iron and zinc content in rice seeds

(2014) Song Tan et al.   TRANSGENIC RESEARCH

Treatment of obesity with the resveratrol-enriched rice DJ-526

(2014) So-Hyeon Baek et al.   Scientific Reports

Human serum albumin from recombinant DNA technology: Challenges and strategies

(2013) Zhen Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Characteristics and Antioxidative Activity of the Acetone-Soluble and -Insoluble Fractions of a Defatted Rice Bran Extract Obtained by Using an Aqueous Organic Solvent under Subcritical Conditions

(2013) Tai-Ying CHIOU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Expression of a Functional Recombinant Human Basic Fibroblast Growth Factor from Transgenic Rice Seeds

(2013) Na An et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed

(2013) Liping Zhang et al.   JOURNAL OF BIOTECHNOLOGY

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

(2013) Daisuke Tokuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Large-scale production and evaluation of marker-free indica rice IR64 expressing phytoferritin genes

(2013) Norman Oliva et al.   MOLECULAR BREEDING

Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification

(2013) Yoshikazu Yuki et al.   PLANT BIOTECHNOLOGY JOURNAL

Transgenic rice seed synthesizing diverse flavonoids at high levels: a new platform for flavonoid production with associated health benefits

(2013) Yuko Ogo et al.   PLANT BIOTECHNOLOGY JOURNAL

Precise plant breeding using new genome editing techniques: opportunities, safety and regulation in the EU

(2013) Frank Hartung et al.   PLANT JOURNAL

ER stress response induced by the production of human IL-7 in rice endosperm cells

(2013) Kyoko Kudo et al.   PLANT MOLECULAR BIOLOGY

Creation of Resveratrol-Enriched Rice for the Treatment of Metabolic Syndrome and Related Diseases

(2013) So-Hyeon Baek et al.   PLoS One

High-level expression of modified gene encoding human adiponectin in transgenic rice

(2012) Feng Liu et al.   BIOLOGICAL RESEARCH

Transgenic Rice Expressing Amyloid β-peptide for Oral Immunization

(2012) Taiji Yoshida et al.   International Journal of Biological Sciences

Growth-Inhibitory Effects of Pigmented Rice Bran Extracts and Three Red Bran Fractions against Human Cancer Cells: Relationships with Composition and Antioxidative Activities

(2012) Ming-Hsuan Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plant-made pharmaceuticals: Leading products and production platforms

(2011) Matthew Paul et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression

(2011) Kazuya Suzuki et al.   PLANT BIOTECHNOLOGY JOURNAL

Constitutive Overexpression of the OsNAS Gene Family Reveals Single-Gene Strategies for Effective Iron- and Zinc-Biofortification of Rice Endosperm

(2011) Alexander A. T. Johnson et al.   PLoS One

Large-scale production of functional human serum albumin from transgenic rice seeds

(2011) Y. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Simple Set of Plasmids for the Production of Transgenic Plants

(2010) Masaharu KURODA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

QUANTIFICATION OF CAROTENOID AND FLAVONOID COMPONENTS IN BRANS OF SOME THAI BLACK RICE CULTIVARS USING SUPERCRITICAL FLUID EXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY

(2010) MUNTANA NAKORNRIAB et al.   JOURNAL OF FOOD LIPIDS

High-level accumulation of recombinant miraculin protein in transgenic tomatoes expressing a synthetic miraculin gene with optimized codon usage terminated by the native miraculin terminator

(2010) Kyoko Hiwasa-Tanase et al.   PLANT CELL REPORTS

Reducing Rice Seed Storage Protein Accumulation Leads to Changes in Nutrient Quality and Storage Organelle Formation

(2010) T. Kawakatsu et al.   PLANT PHYSIOLOGY

Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine

(2010) D. Tokuhara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraction and purification of human interleukin-10 from transgenic rice seeds

(2010) Yoshihiro Fujiwara et al.   PROTEIN EXPRESSION AND PURIFICATION

Generation and immunogenicity of Japanese encephalitis virus envelope protein expressed in transgenic rice

(2009) Yuanyuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biorefinery: Toward an industrial metabolism

(2009) Stéphane Octave et al.   BIOCHIMIE

Oral administration of recombinant human granulocyte-macrophage colony stimulating factor expressed in rice endosperm can increase leukocytes in mice

(2008) Tingting Ning et al.   BIOTECHNOLOGY LETTERS

Characterization of a new rice glutelin gene GluD-1 expressed in the starchy endosperm

(2008) Taiji Kawakatsu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Proteomic Analysis of Rice Endosperm Cells in Response to Expression of hGM-CSF

(2008) Junling Luo et al.   JOURNAL OF PROTEOME RESEARCH

Sustained Expression of Human Cytomegalovirus Glycoprotein B (UL55) in the Seeds of Homozygous Rice Plants

(2008) Eilleen S. Tackaberry et al.   MOLECULAR BIOTECHNOLOGY

A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery

(2008) Tingting Xie et al.   PEPTIDES

Preventing unintended proteolysis in plant protein biofactories

(2008) Meriem Benchabane et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of human growth hormone in transgenic rice cell suspension culture

(2008) Tae-Geum Kim et al.   PLANT CELL REPORTS

Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit

(2008) Yasunobu Matsumoto et al.   TRANSGENIC RESEARCH

Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy

(2007) Lijun Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS