Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone

NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection

(2018) Soo Jung Cho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection

(2018) Soo Jung Cho et al.   EXPERIMENTAL GERONTOLOGY

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

(2018) Andreas Nerlich et al.   Scientific Reports

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

(2017) Kerstin Boengler et al.   Journal of Cachexia Sarcopenia and Muscle

Age-Enhanced Endoplasmic Reticulum Stress Contributes to Increased Atg9A Inhibition of STING-Mediated IFN-  Production during Streptococcus pneumoniae Infection

(2014) D. N. Mitzel et al.   JOURNAL OF IMMUNOLOGY

Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

(2013) Jon D. Simmons et al.   ANNALS OF SURGERY

Persistent damage induces mitochondrial DNA degradation

(2013) Inna N. Shokolenko et al.   DNA REPAIR

Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status

(2013) Satoshi Yamanouchi et al.   JOURNAL OF CRITICAL CARE

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

(2013) Anna-Maria Joseph et al.   PLoS One

Improved Mitochondrial Function Underlies the Protective Effect of Pirfenidone against Tubulointerstitial Fibrosis in 5/6 Nephrectomized Rats

(2013) Jun-Feng Chen et al.   PLoS One

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Immune modulatory effects of the foodborne contaminant citrinin in mice

(2012) Mohammad Rafiqul Islam et al.   FOOD AND CHEMICAL TOXICOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes

(2011) Daniel C. Andersson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells

(2010) Marleen Forkink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Pneumonia in the elderly

(2009) Mateo Cabre   CURRENT OPINION IN PULMONARY MEDICINE

How can we improve the management and outcome of pneumonia in the elderly?

(2008) V. Brito et al.   EUROPEAN RESPIRATORY JOURNAL

Pneumonia and Mortality in Elderly Patients

(2008) Renzo Rozzini et al.   Journal of the American Medical Directors Association