Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

(2019) Abubakar Wani et al.   Autophagy

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

An enriched environment restores hepatitis B vaccination-mediated impairments in synaptic function through IFN-γ/Arginase1 signaling

(2018) Fangfang Qi et al.   BRAIN BEHAVIOR AND IMMUNITY

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

(2018) Towfique Raj et al.   NATURE GENETICS

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

(2018) Christy O.Y. Hung et al.   Cell Reports

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer’s Disease Brain

(2017) Mohammad Ejaz Ahmed et al.   JOURNAL OF ALZHEIMERS DISEASE

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model

(2017) Zhong-Hao Zhang et al.   JOURNAL OF NEUROSCIENCE

Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic Mice

(2016) Yiren Qin et al.   JOURNAL OF IMMUNOLOGY

p62 improves AD-like pathology by increasing autophagy

(2016) A Caccamo et al.   MOLECULAR PSYCHIATRY

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease AdvaxCpG- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules

(2016) Hayk Davtyan et al.   Scientific Reports

Atorvastatin prevents Aβ oligomer-induced neurotoxicity in cultured rat hippocampal neurons by inhibiting Tau cleavage

(2015) Hai-juan Sui et al.   ACTA PHARMACOLOGICA SINICA

Neonatal vaccination with bacillus Calmette–Guérin and hepatitis B vaccines modulates hippocampal synaptic plasticity in rats

(2015) Qingqing Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

In Vivo Application of beta Amyloid Oligomers: A Simple Tool to Evaluate Mechanisms of Action and New Therapeutic Approaches

(2015) Claudia Balducci et al.   CURRENT PHARMACEUTICAL DESIGN

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

(2014) Dun-Sheng Yang et al.   BRAIN

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance

(2014) Y. Shibuya et al.   JOURNAL OF NEUROSCIENCE

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Autophagy activation by interferon-γ via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity

(2013) Takeshi Matsuzawa et al.   IMMUNOLOGY

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

(2013) Miranda E. Orr et al.   NEUROBIOLOGY OF AGING

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging

(2013) Sara Sepe et al.   NEUROBIOLOGY OF AGING

Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathways

(2012) Ying Jin et al.   ACTA PHARMACOLOGICA SINICA

IFN-  Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

(2012) T. Matsuzawa et al.   JOURNAL OF IMMUNOLOGY

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Latanoprost Promotes Neurite Outgrowth in Differentiated RGC-5 Cells via the PI3K-Akt-mTOR Signaling Pathway

(2011) Jun Zheng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Two Faces of Interferon-  in Cancer

(2011) M. R. Zaidi et al.   CLINICAL CANCER RESEARCH

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN-  Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid   Precursor Protein Transgenic Mice

(2010) P. Chakrabarty et al.   JOURNAL OF IMMUNOLOGY

CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-  Phagocytosis

(2010) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-γ: A historical perspective

(2009) Alfons Billiau et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

IFN-γ enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer’s disease

(2008) Rona Baron et al.   FASEB JOURNAL

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

(2007) Avinash R. Shenoy et al.   IMMUNOBIOLOGY