Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting

Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex

(2018) Kan Kobayashi et al.   SCIENCE

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence

(2017) Evan Mercier et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

(2016) Klemens Wild et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

The Code for Directing Proteins for Translocation across ER Membrane: SRP Cotranslationally Recognizes Specific Features of a Signal Sequence

(2015) IngMarie Nilsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosome–SRP–FtsY cotranslational targeting complex in the closed state

(2015) Ottilie von Loeffelholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Signal-sequence induced conformational changes in the signal recognition particle

(2015) Tobias Hainzl et al.   Nature Communications

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle

(2014) Xin Zhang et al.   Annual Review of Biophysics

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

(2014) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Signal Recognition Particle: An Essential Protein-Targeting Machine

(2013) David Akopian et al.   Annual Review of Biochemistry

Molecular Mechanism of GTPase Activation at the Signal Recognition Particle (SRP) RNA Distal End

(2013) Kuang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions

(2013) Carla P Guimaraes et al.   Nature Protocols

Identifying Molecular Dynamics in Single-Molecule FRET Experiments with Burst Variance Analysis

(2011) Joseph P. Torella et al.   BIOPHYSICAL JOURNAL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Structural basis of signal-sequence recognition by the signal recognition particle

(2011) Tobias Hainzl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting

(2011) K. Shen et al.   RNA

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

(2011) S. F. Ataide et al.   SCIENCE

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein

(2010) C. Mary et al.   RNA

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

(2010) X. Zhang et al.   SCIENCE

Multiple conformational switches in a GTPase complex control co-translational protein targeting

(2009) Xin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal Sequences Activate the Catalytic Switch of SRP RNA

(2009) N. Bradshaw et al.   SCIENCE

Demonstration of a Multistep Mechanism for Assembly of the SRP·SRP Receptor Complex: Implications for the Catalytic Role of SRP RNA

(2008) Xin Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY