rDNA array length is a major determinant of replicative lifespan in budding yeast

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

(2021) Ruofan Yu et al.   Nature Communications

NORs on human acrocentric chromosome p-arms are active by default and can associate with nucleoli independently of rDNA

(2020) Marjolein van Sluis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Polymerase I Activators Count and Adjust Ribosomal RNA Gene Copy Number

(2019) Tetsushi Iida et al.   MOLECULAR CELL

Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics

(2019) Meng Jin et al.   Cell Systems

Genome architecture and stability in the Saccharomyces cerevisiae knockout collection

(2019) Fabio Puddu et al.   NATURE

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

(2018) Silvana Paredes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

(2018) Kevin L Lu et al.   eLife

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

(2018) Matthew M. Parks et al.   Science Advances

Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles

(2018) Andrés Mansisidor et al.   MOLECULAR CELL

A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

(2018) David G Hendrickson et al.   eLife

Multigenerational silencing dynamics control cell aging

(2017) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance

(2016) Kimiko Saka et al.   NUCLEIC ACIDS RESEARCH

Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice

(2016) Michelle L. Holland et al.   SCIENCE

rDNA Copy Number Variants Are Frequent Passenger Mutations in Saccharomyces cerevisiae Deletion Collections and de Novo Transformants

(2016) Elizabeth X. Kwan et al.   G3-Genes Genomes Genetics

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Regulation of ribosomal DNA amplification by the TOR pathway

(2015) Carmen V. Jack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput analysis of yeast replicative aging using a microfluidic system

(2015) Myeong Chan Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Inheritance of Diet-Induced Genome Rearrangements in Drosophila

(2015) John C. Aldrich et al.   PLoS Genetics

Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae

(2014) D. H. E. W. Huberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal DNA copy number is coupled with gene expression variation and mitochondrial abundance in humans

(2014) John G. Gibbons et al.   Nature Communications

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

(2014) Chong He et al.   PLoS Genetics

Cellular Senescence in Yeast Is Regulated by rDNA Noncoding Transcription

(2013) Kimiko Saka et al.   CURRENT BIOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes

(2013) P. A. Gibney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular phenotyping of aging in single yeast cells using a novel microfluidic device

(2012) Zhengwei Xie et al.   AGING CELL

Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform

(2012) S. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell size and growth rate are major determinants of replicative lifespan

(2011) Jingye Yang et al.   CELL CYCLE

Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

(2011) Derek L. Lindstrom et al.   PLoS Genetics

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

(2011) Undine Kruegel et al.   PLoS Genetics

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

(2009) Cheuk Hei Ho et al.   NATURE BIOTECHNOLOGY

Measuring Replicative Life Span in the Budding Yeast

(2009) Kristan K. Steffen et al.   Jove-Journal of Visualized Experiments

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

A Genetic Screen for Increased Loss of Heterozygosity in Saccharomyces cerevisiae

(2008) M. P. Andersen et al.   GENETICS

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH