The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3

(2016) Z Li et al.   ONCOGENE

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo

(2016) Nickolai A. Tchurikov et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats

(2015) Agata Wronska et al.   GERONTOLOGY

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Ribosomal RNA gene repeats, their stability and cellular senescence

(2014) Takehiko KOBAYASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging

(2014) Namgyu Lee et al.   PROTEOMICS

Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation

(2014) Nickolai A. Tchurikov et al.   Journal of Molecular Cell Biology

Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging

(2013) Austen R. D. Ganley et al.   FEMS YEAST RESEARCH

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

(2013) Sifan Chen et al.   MOLECULAR CELL

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription

(2012) Yuan-Chin Tsai et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

(2012) Matthew F. Barber et al.   NATURE

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

(2011) C. Rieker et al.   JOURNAL OF NEUROSCIENCE

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

(2011) Maciej Pietrzak et al.   PLoS One

Ribosomal DNA Deletions Modulate Genome-Wide Gene Expression: “rDNA–Sensitive” Genes and Natural Variation

(2011) Silvana Paredes et al.   PLoS Genetics

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

(2010) Claudio Guetg et al.   EMBO JOURNAL

Efficient extraction of nucleolar proteins for interactome analyses

(2010) Delphine Chamousset et al.   PROTEOMICS

Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer

(2009) D. M. Stults et al.   CANCER RESEARCH

Expression of I-CreI Endonuclease Generates Deletions Within the rDNA of Drosophila

(2009) S. Paredes et al.   GENETICS

Loss of Bloom syndrome protein destabilizes human gene cluster architecture

(2009) Michael W. Killen et al.   HUMAN MOLECULAR GENETICS

Ribosomal DNA contributes to global chromatin regulation

(2009) S. Paredes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

(2008) Brian McStay et al.   Annual Review of Cell and Developmental Biology

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY