Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
出版年份 2022 全文链接
标题
Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 19, Pages -
出版商
Proceedings of the National Academy of Sciences
发表日期
2022-05-06
DOI
10.1073/pnas.2200559119
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
- (2022) Pétur O. Heidarsson et al. Nature Chemistry
- Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures
- (2021) Xiangze Zeng et al. APL Materials
- Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Side Chains of Amino Acids
- (2021) Martin J. Fossat et al. JOURNAL OF PHYSICAL CHEMISTRY B
- How multisite phosphorylation impacts the conformations of intrinsically disordered proteins
- (2021) Fan Jin et al. PLoS Computational Biology
- Diffusion of a disordered protein on its folded ligand
- (2021) Felix Wiggers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
- (2021) Cesar L. Cuevas-Velazquez et al. Nature Communications
- Quantifying charge state heterogeneity for proteins with multiple ionizable residues
- (2021) Martin J. Fossat et al. BIOPHYSICAL JOURNAL
- Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution
- (2021) Lasse Staby et al. JOURNAL OF MOLECULAR BIOLOGY
- Single-molecule Detection of Ultrafast Biomolecular Dynamics with Nanophotonics
- (2021) Mark F. Nüesch et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
- (2021) Anne Bremer et al. Nature Chemistry
- Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties
- (2021) Giulio Tesei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning
- (2020) Alex S. Holehouse et al. Journal of Chemical Theory and Computation
- Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation
- (2020) Jamie A. Greig et al. MOLECULAR CELL
- Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
- (2020) Erik W. Martin et al. SCIENCE
- An analytical theory to describe sequence-specific inter-residue distance profiles for polyampholytes and intrinsically disordered proteins
- (2020) Jonathan Huihui et al. JOURNAL OF CHEMICAL PHYSICS
- Dissecting the Functional Contributions of the Intrinsically Disordered C-terminal Tail of Bacillus subtilis FtsZ
- (2020) Megan C. Cohan et al. JOURNAL OF MOLECULAR BIOLOGY
- Interactions by Disorder – A Matter of Context
- (2020) Katrine Bugge et al. Frontiers in Molecular Biosciences
- Revealing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment
- (2020) David Moses et al. Journal of Physical Chemistry Letters
- Improvements to the ABSINTH forcefield for proteins based on experimentally derived amino-acid specific backbone conformational statistics
- (2019) Jeong-Mo Choi et al. Journal of Chemical Theory and Computation
- Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins
- (2019) Rebecca Beveridge et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains
- (2019) Szabo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
- (2019) Maksym Tsytlonok et al. Nature Communications
- q-Canonical Monte Carlo Sampling for Modeling the Linkage Between Charge Regulation and Conformational Equilibria of Peptides
- (2019) Martin J Fossat et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered Proteins Is Regulated through Zinc-Histidine Interactions
- (2019) Carolina Cragnell et al. Biomolecules
- Polymer effects modulate binding affinities in disordered proteins
- (2019) Renee Vancraenenbroeck et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Information theoretic measures for quantifying sequence–ensemble relationships of intrinsically disordered proteins
- (2019) Megan C Cohan et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics
- (2019) Charlotte S. Sørensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Binding without folding – the biomolecular function of disordered polyelectrolyte complexes
- (2019) Benjamin Schuler et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Collapse Transitions of Proteins and the Interplay Among Backbone, Sidechain, and Solvent Interactions
- (2018) Alex S. Holehouse et al. Annual Review of Biophysics
- Intrinsically Disordered Protein Exhibits Both Compaction and Expansion under Macromolecular Crowding
- (2018) Anthony Banks et al. BIOPHYSICAL JOURNAL
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Sequence charge decoration dictates coil-globule transition in intrinsically disordered proteins
- (2018) Taylor Firman et al. JOURNAL OF CHEMICAL PHYSICS
- Sequence-to-Conformation Relationships of Disordered Regions Tethered to Folded Domains of Proteins
- (2018) Anuradha Mittal et al. JOURNAL OF MOLECULAR BIOLOGY
- A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
- (2018) Kristian K. Kristensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain
- (2018) Max V. Staller et al. Cell Systems
- Local and Global Dynamics in Intrinsically Disordered Synuclein
- (2018) Nasrollah Rezaei-Ghaleh et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Extreme disorder in an ultrahigh-affinity protein complex
- (2018) Alessandro Borgia et al. NATURE
- Highly disordered histone H1−DNA model complexes and their condensates
- (2018) Abigail L. Turner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutamate promotes SSB protein–protein Interactions via intrinsically disordered regions
- (2017) Alexander G. Kozlov et al. JOURNAL OF MOLECULAR BIOLOGY
- Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure
- (2017) Basile I. M. Wicky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
- (2017) Jacob P. Brady et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor
- (2017) Kathryn P. Sherry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sequence and entropy-based control of complex coacervates
- (2017) Li-Wei Chang et al. Nature Communications
- Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System
- (2016) Mainak Guharoy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications
- (2016) Alaji Bah et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation
- (2016) Erik W. Martin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles
- (2016) Yi-Hsuan Lin et al. PHYSICAL REVIEW LETTERS
- Cryptic sequence features within the disordered protein p27Kip1regulate cell cycle signaling
- (2016) Rahul K. Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Asymmetric Modulation of Protein Order-Disorder Transitions by Phosphorylation and Partner Binding
- (2015) Priya R. Banerjee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Theoretical perspectives on nonnative interactions and intrinsic disorder in protein folding and binding
- (2015) Tao Chen et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Relating sequence encoded information to form and function of intrinsically disordered proteins
- (2015) Rahul K Das et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- A theoretical method to compute sequence dependent configurational properties in charged polymers and proteins
- (2015) Lucas Sawle et al. JOURNAL OF CHEMICAL PHYSICS
- Sequence- and Temperature-Dependent Properties of Unfolded and Disordered Proteins from Atomistic Simulations
- (2015) Gül H. Zerze et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Visualizing the Molecular Recognition Trajectory of an Intrinsically Disordered Protein Using Multinuclear Relaxation Dispersion NMR
- (2015) Robert Schneider et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck
- (2015) Sudeep Banjade et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Classification of Intrinsically Disordered Regions and Proteins
- (2014) Robin van der Lee et al. CHEMICAL REVIEWS
- A simple molecular mechanics integrator in mixed rigid body and dihedral angle space
- (2014) Andreas Vitalis et al. JOURNAL OF CHEMICAL PHYSICS
- Long-Range Correlated Dynamics in Intrinsically Disordered Proteins
- (2014) Giacomo Parigi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells
- (2014) Wade Borcherds et al. Nature Chemical Biology
- Temperature-dependent solvation modulates the dimensions of disordered proteins
- (2014) R. Wuttke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multisteric Regulation by Structural Disorder in Modular Signaling Proteins: An Extension of the Concept of Allostery
- (2013) Peter Tompa CHEMICAL REVIEWS
- Describing intrinsically disordered proteins at atomic resolution by NMR
- (2013) Malene Ringkjøbing Jensen et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- A quantitative measure for protein conformational heterogeneity
- (2013) Nicholas Lyle et al. JOURNAL OF CHEMICAL PHYSICS
- Modulation of allostery by protein intrinsic disorder
- (2013) Allan Chris M. Ferreon et al. NATURE
- Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
- (2013) R. K. Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering
- (2013) Martin Schwalbe et al. STRUCTURE
- Crystal lattice properties fully determine short-range interaction parameters for alkali and halide ions
- (2012) Albert H. Mao et al. JOURNAL OF CHEMICAL PHYSICS
- Improved Atomistic Monte Carlo Simulations Demonstrate That Poly-l-Proline Adopts Heterogeneous Ensembles of Conformations of Semi-Rigid Segments Interrupted by Kinks
- (2012) Aditya Radhakrishnan et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence
- (2012) L. Y. Beh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
- (2012) H. Hofmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of an IDP binding mechanism and rates by helix propensity and non-native interactions: association of HIF1α with CBP
- (2011) David De Sancho et al. Molecular BioSystems
- Sequence Determinants of Compaction in Intrinsically Disordered Proteins
- (2010) Joseph A. Marsh et al. BIOPHYSICAL JOURNAL
- Effective Charge and Coil−Globule Transition of a Polyelectrolyte Chain
- (2010) Arindam Kundagrami et al. MACROMOLECULES
- Factors Governing Fibrillogenesis of Polypeptide Chains Revealed by Lattice Models
- (2010) Mai Suan Li et al. PHYSICAL REVIEW LETTERS
- Net charge per residue modulates conformational ensembles of intrinsically disordered proteins
- (2010) A. H. Mao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Charge interactions can dominate the dimensions of intrinsically disordered proteins
- (2010) S. Muller-Spath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Theory of polyzwitterion conformations
- (2009) Rajeev Kumar et al. JOURNAL OF CHEMICAL PHYSICS
- Probing the mechanisms of fibril formation using lattice models
- (2008) Mai Suan Li et al. JOURNAL OF CHEMICAL PHYSICS
- ABSINTH: A new continuum solvation model for simulations of polypeptides in aqueous solutions
- (2008) Andreas Vitalis et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More