Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Determination of the Carboxyl Dissociation Degree and pK a Value of Mono and Polyacid Solutions by FTIR Titration

(2021) Martin Müller et al.   MACROMOLECULAR CHEMISTRY AND PHYSICS

Molecular Transfer Model for pH Effects on Intrinsically Disordered Proteins: Theory and Applications

(2021) Mauro Lorenzo Mugnai et al.   Journal of Chemical Theory and Computation

Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies

(2021) Taranpreet Kaur et al.   Nature Communications

Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Side Chains of Amino Acids

(2021) Martin J. Fossat et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Transfer Matrix Model of pH Effects in Polymeric Complex Coacervation

(2021) Ashley R. Knoerdel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Diffusion of a disordered protein on its folded ligand

(2021) Felix Wiggers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Standard state free energies, not pKas, are ideal for describing small molecule protonation and tautomeric states

(2020) M. R. Gunner et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

(2020) Jamie A. Greig et al.   MOLECULAR CELL

pH-Controlled Coacervate–Membrane Interactions within Liposomes

(2020) Mart G. F. Last et al.   ACS Nano

Catalytic Site pKa Values of Aspartic, Cysteine, and Serine Proteases: Constant pH MD Simulations

(2020) Florian Hofer et al.   Journal of Chemical Information and Modeling

Liquid-liquid phase separation drives skin barrier formation

(2020) Felipe Garcia Quiroz et al.   SCIENCE

Phase transition of RNA−protein complexes into ordered hollow condensates

(2020) Ibraheem Alshareedah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions by Disorder – A Matter of Context

(2020) Katrine Bugge et al.   Frontiers in Molecular Biosciences

Intrinsically disordered linkers control tethered kinases via effective concentration

(2020) Mateusz Dyla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable multiphase dynamics of arginine and lysine liquid condensates

(2020) Rachel S. Fisher et al.   Nature Communications

Role of electrostatic interactions in charge regulation of weakly dissociating polyacids

(2020) Mohsen Ghasemi et al.   PROGRESS IN POLYMER SCIENCE

PKAD: a database of experimentally measured pKa values of ionizable groups in proteins

(2019) Swagata Pahari et al.   Database-The Journal of Biological Databases and Curation

The PCNA interaction motifs revisited: thinking outside the PIP-box

(2019) Andreas Prestel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

q-Canonical Monte Carlo Sampling for Modeling the Linkage Between Charge Regulation and Conformational Equilibria of Peptides

(2019) Martin J Fossat et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Specificity of MYB interactions relies on motifs in ordered and disordered contexts

(2019) Peter S Millard et al.   NUCLEIC ACIDS RESEARCH

Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics

(2019) Charlotte S. Sørensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme Kinetics via Open Circuit Potentiometry

(2019) Lettie A. Smith et al.   ANALYTICAL CHEMISTRY

A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain

(2018) Max V. Staller et al.   Cell Systems

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

Folding of poly-amino acids and intrinsically disordered proteins in overcrowded milieu induced by pH change

(2018) Alexander V. Fonin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Lysine acetylation and cancer: A proteomics perspective

(2017) Jeovanis Gil et al.   Journal of Proteomics

Single-molecule electrometry

(2017) Francesca Ruggeri et al.   Nature Nanotechnology

Sequence and entropy-based control of complex coacervates

(2017) Li-Wei Chang et al.   Nature Communications

Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability

(2017) Marcin Wolny et al.   Scientific Reports

ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells

(2017) Rabia U. Malik et al.   Scientific Reports

Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1

(2016) Charlotte O'Shea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications

(2016) Alaji Bah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Charge-Neutral Constant pH Molecular Dynamics Simulations Using a Parsimonious Proton Buffer

(2016) Serena Donnini et al.   Journal of Chemical Theory and Computation

A Molecular Thermodynamic Model of Complexation in Mixtures of Oppositely Charged Polyelectrolytes with Explicit Account of Charge Association/Dissociation

(2016) Ali Salehi et al.   MACROMOLECULES

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

(2016) Chi W. Pak et al.   MOLECULAR CELL

Microscopic mechanisms that govern the titration response and pK a values of buried residues in staphylococcal nuclease mutants

(2016) Yuqing Zheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

(2015) Jakob Fuhrmann et al.   ACS Chemical Biology

Local and macroscopic electrostatic interactions in single α-helices

(2015) Emily G Baker et al.   Nature Chemical Biology

Arginine: Its pKavalue revisited

(2015) Carolyn A. Fitch et al.   PROTEIN SCIENCE

Single-Molecule Studies of Intrinsically Disordered Proteins

(2014) Marco Brucale et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Protein Ser/Thr/Tyr Phosphorylation in the Archaea

(2014) Peter J. Kennelly   JOURNAL OF BIOLOGICAL CHEMISTRY

pH-dependent random coil 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements

(2014) Gerald Platzer et al.   JOURNAL OF BIOMOLECULAR NMR

The Effect of Intrachain Electrostatic Repulsion on Conformational Disorder and Dynamics of the Sic1 Protein

(2014) Baoxu Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Temperature-dependent solvation modulates the dimensions of disordered proteins

(2014) R. Wuttke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of pH and Binding of Multivalent Metal Ions: Charge Inversion and Reentrant Condensation in Protein Solutions

(2013) Felix Roosen-Runge et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Charge regulation in biomolecular solution

(2013) Mikael Lund et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Describing sequence–ensemble relationships for intrinsically disordered proteins

(2012) Albert H. Mao et al.   BIOCHEMICAL JOURNAL

pH-jump induced α-helix folding of poly-l-glutamic acid

(2012) Mateusz L. Donten et al.   CHEMICAL PHYSICS

Electrostatic Contribution of Surface Charge Residues to the Stability of a Thermophilic Protein: Benchmarking Experimental and Predicted pKa Values

(2012) Chi-Ho Chan et al.   PLoS One

Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy

(2012) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of pH on Proteins: Predictions for Ensemble and Single-Molecule Pulling Experiments

(2011) Edward P. O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence Determinants of Compaction in Intrinsically Disordered Proteins

(2010) Joseph A. Marsh et al.   BIOPHYSICAL JOURNAL

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charges in the hydrophobic interior of proteins

(2010) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of proton linkage to the thermodynamic stability of the major cold-shock protein of Escherichia coli CspA

(2010) Susan A. Petrosian et al.   PROTEIN SCIENCE

Universality of protein reentrant condensation in solution induced by multivalent metal ions

(2010) Fajun Zhang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural plasticity of staphylococcal nuclease probed by perturbation with pressure and pH

(2010) Ryo Kitahara et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Diversity in Free and Bound States of Intrinsically Disordered Protein Phosphatase 1 Regulators

(2010) Joseph A. Marsh et al.   STRUCTURE

Protein Ionizable Groups: pKValues and Their Contribution to Protein Stability and Solubility

(2009) C. Nick Pace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pKa Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different Factors

(2009) Michael J. Harms et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular determinants of the pKavalues of Asp and Glu residues in staphylococcal nuclease

(2009) Carlos A. Castañeda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystallographic Study of Hydration of an Internal Cavity in Engineered Proteins with Buried Polar or Ionizable Groups

(2008) Jamie L. Schlessman et al.   BIOPHYSICAL JOURNAL

Charged single α-helix: A versatile protein structural motif

(2008) Dániel Süveges et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS