CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

Progress in the Development of Preventative Drugs for Cisplatin-Induced Hearing Loss

(2018) Robert A. Hazlitt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children’s Oncology Group

(2017) Kristin R. Knight et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

(2017) David R Freyer et al.   LANCET ONCOLOGY

Cisplatin is retained in the cochlea indefinitely following chemotherapy

(2017) Andrew M. Breglio et al.   Nature Communications

Nuclear DNA damage signalling to mitochondria in ageing

(2016) Evandro Fei Fang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Guidelines for Auditory Threshold Measurement for Significant Threshold Shift

(2016) Kathleen Campbell et al.   OTOLOGY & NEUROTOLOGY

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménièreʼs Disease

(2016) Paul R. Lambert et al.   OTOLOGY & NEUROTOLOGY

Recent advances in local drug delivery to the inner ear

(2015) Naila El Kechai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gene Expression by Mouse Inner Ear Hair Cells during Development

(2015) D. I. Scheffer et al.   JOURNAL OF NEUROSCIENCE

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

(2015) Heng Xu et al.   NATURE GENETICS

New treatment options for hearing loss

(2015) Ulrich Müller et al.   NATURE REVIEWS DRUG DISCOVERY

Hidden Hearing Loss

(2015) M. Charles Liberman   SCIENTIFIC AMERICAN

Discovery of Small Molecules that Inhibit the Disordered Protein, p27 Kip1

(2015) Luigi I. Iconaru et al.   Scientific Reports

Pemetrexed and Gemcitabine as Combination Therapy for the Treatment of Group3 Medulloblastoma

(2014) Marie Morfouace et al.   CANCER CELL

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

(2014) M. D. Hall et al.   CANCER RESEARCH

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice

(2014) Yali Zhang et al.   DIABETES

In Vivo Generation of Immature Inner Hair Cells in Neonatal Mouse Cochleae by Ectopic Atoh1 Expression

(2014) Zhiyong Liu et al.   PLoS One

A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

(2013) Yin M. Yang et al.   Cell Stem Cell

Sound preconditioning therapy inhibits ototoxic hearing loss in mice

(2013) Soumen Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Mechanotransduction Is Required for Cisplatin-Induced Hair Cell Death in the Zebrafish Lateral Line

(2013) A. J. Thomas et al.   JOURNAL OF NEUROSCIENCE

Review: Ototoxic Characteristics of Platinum Antitumor Drugs

(2012) Dalian Ding et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Independent transcriptional reprogramming and apoptosis induction by cisplatin

(2012) Lorenzo Galluzzi et al.   CELL CYCLE

TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1

(2012) Masatsugu Masuda et al.   DEVELOPMENTAL BIOLOGY

Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin

(2012) Anna L. Vlasits et al.   HEARING RESEARCH

Quinoline Ring Derivatives Protect Against Aminoglycoside-Induced Hair Cell Death in the Zebrafish Lateral Line

(2012) Henry C. Ou et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Normal Hearing Sensitivity at Low-to-Middle Frequencies with 34% Prestin-Charge Density

(2012) Tetsuji Yamashita et al.   PLoS One

Emerging treatments for noise-induced hearing loss

(2011) Naoki Oishi et al.   EXPERT OPINION ON EMERGING DRUGS

Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish

(2011) Lauren M.J. Buck et al.   HEARING RESEARCH

Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis

(2011) Xiao-Xi Guo et al.   Protein & Cell

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

(2010) Giuliano Ciarimboli et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles of NADPH Oxidases in Cisplatin-Induced Reactive Oxygen Species Generation and Ototoxicity

(2010) H.-J. Kim et al.   JOURNAL OF NEUROSCIENCE

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Screening for Hair Cell Loss and Protection in the Zebrafish Lateral Line

(2010) Allison B. Coffin et al.   Zebrafish

Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways

(2009) Kelly N. Owens et al.   HEARING RESEARCH

Adding Insult to Injury: Cochlear Nerve Degeneration after "Temporary" Noise-Induced Hearing Loss

(2009) S. G. Kujawa et al.   JOURNAL OF NEUROSCIENCE

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy

(2009) Colin J D Ross et al.   NATURE GENETICS

Protective Effects of Acetyl-l-Carnitine on Cisplatin Cytotoxicity and Oxidative Stress in Neuroblastoma

(2009) Zekiye Sultan Altun et al.   NEUROCHEMICAL RESEARCH

Amifostine Protects Against Cisplatin-Induced Ototoxicity in Children With Average-Risk Medulloblastoma

(2008) Maryam Fouladi et al.   JOURNAL OF CLINICAL ONCOLOGY

Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

(2008) V. Hellberg et al.   JNCI-Journal of the National Cancer Institute