Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation
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Title
Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 11, Pages -
Publisher
Proceedings of the National Academy of Sciences
Online
2022-03-08
DOI
10.1073/pnas.2121353119
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Note: Only part of the references are listed.- NLRP3 inflammasome in cancer and metabolic diseases
- (2021) Bhesh Raj Sharma et al. NATURE IMMUNOLOGY
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- (2021) Zsófia Agnes Bittner et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2021) Liudmila Andreeva et al. CELL
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- NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
- (2021) Tingting Niu et al. Nature Communications
- HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
- (2020) Venkat Giri Magupalli et al. SCIENCE
- Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
- (2019) Yang Yang et al. Cell Death & Disease
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
- (2019) Rebecca C. Coll et al. Nature Chemical Biology
- MCC950 closes the active conformation of NLRP3 to an inactive state
- (2019) Ana Tapia-Abellán et al. Nature Chemical Biology
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- Pharmacological Inhibitors of the NLRP3 Inflammasome
- (2019) Ayesha Zahid et al. Frontiers in Immunology
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
- (2018) Jueqi Chen et al. NATURE
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
- (2017) Andrea Stutz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Protein kinase D at the Golgi controls NLRP3 inflammasome activation
- (2017) Zhirong Zhang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
- (2017) Nan Song et al. MOLECULAR CELL
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
- (2016) Chuansheng Guo et al. IMMUNITY
- Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
- (2016) Michael J. Primiano et al. JOURNAL OF IMMUNOLOGY
- The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
- (2016) Marina Saresella et al. Molecular Neurodegeneration
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- Crystal structure of NOD2 and its implications in human disease
- (2016) Sakiko Maekawa et al. Nature Communications
- Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome
- (2015) Yiqing Yan et al. CELL
- Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase
- (2015) SeungHye Han et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation
- (2015) Jonathan L. Schmid-Burgk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
- (2015) Hexin Shi et al. NATURE IMMUNOLOGY
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
- Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia
- (2014) Justine M. Abais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome
- (2013) Hiroki Mitoma et al. IMMUNITY
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
- (2013) Z. Hu et al. SCIENCE
- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation
- (2012) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
- (2012) Gloria Lopez-Castejon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Novel role of PKR in inflammasome activation and HMGB1 release
- (2012) Ben Lu et al. NATURE
- Inflammasome is a central player in the induction of obesity and insulin resistance
- (2011) R. Stienstra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- The Inflammasomes
- (2010) Kate Schroder et al. CELL
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- (2010) C. Bauer et al. GUT
- The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis
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- (2010) Rongbin Zhou et al. NATURE
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- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
- (2008) Alexandra-Chloé Villani et al. NATURE GENETICS
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
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