Article
Immunology
Wenyang Jiang, Jie Ren, Hongling Zhou, Ruyuan He, Donghang Li, Rui Xiong, Zhuokun He, Dan Cheng
Summary: This study found that TMEM16A plays an important role in sepsis-induced acute lung injury (ALI) by regulating endoplasmic reticulum stress-induced ferroptosis in alveolar epithelial type II (AT2) cells. Knockout of TMEM16A improved lung function and alleviated lung pathological injury in LPS-treated mice. Inhibition of TMEM16A by shikonin also showed therapeutic effect on LPS-induced ALI in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Aming Sang, Yun Wang, Shun Wang, Qingyuan Wang, Xiaohua Wang, Xinyi Li, Xuemin Song
Summary: This study found that quercetin can protect against sepsis-induced acute lung injury by suppressing endoplasmic reticulum stress and mitochondrial dysfunction. The protective effect is achieved through induction of the SIRT1/AMPK pathway and reduction of oxidative damage.
CELLULAR SIGNALLING
(2022)
Review
Biochemistry & Molecular Biology
Stefan W. Ryter
Summary: Heme molecule is essential for oxygen transport, cellular metabolic enzyme activities, and can promote human diseases if dysfunction occurs. It has pro-oxidant properties, inducing cytotoxicity and injury, while also modulating inflammatory and immune system functions. Therapeutic strategies targeting the heme/HO-1 pathway show potential in inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yang Huang, Zi Ye, Yujing Yin, Tianju Ma, Qi Zhang, Kun Shang, Wenqian Chen, Zhaohui Li
Summary: The loss of HO-1 enzymatic activity induces early-onset nuclear cataracts by activating oxidative stress and ER stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Fuquan Wang, Jiamin Ma, Jingxu Wang, Ming Chen, Haifa Xia, Shanglong Yao, Dingyu Zhang
Summary: This study found that increased expression of SIRT1 can significantly improve sepsis-related lung injury and inhibit ER stress response and macrophage apoptosis. The protective effect of SIRT1 is mediated through the PERK/eIF2-alpha/ATF4/CHOP pathway.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Immunology
Tao Zeng, Yan Zhou, Yang Yu, Jian-wen Wang, Yao Wu, Xin Wang, Ling Zhu, Li-ming Zhou, Li-hong Wan
Summary: Ferroptosis is involved in LPS-induced acute lung injury and is regulated by endoplasmic reticulum stress. It has been found that mesencephalic astrocyte-derived neurotrophic factor (MANF) can attenuate LPS-induced lung injury by repressing macrophage activation. This study investigated the preventive role of MANF on ferroptosis and excessive endoplasmic reticulum stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Simeng He, Jia Shi, Wenming Liu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Xiangyun Li, Qiaoying Gao, Jing Yang, Jianbo Yu
Summary: The present study found that heme oxygenase-1 (HO-1) can attenuate endotoxin-induced acute lung injury (ALI) by regulating nicotinamide adenine dinucleotide (NAD(+)) and NAD(+)-mediated mitonuclear communication through the PGC1 alpha/PPAR gamma pathway. The study observed that NAD(+) affected mitonuclear communication and imbalance, and that the inhibition of the PGC1 alpha/PPAR gamma signaling exacerbated septic lung injury by reducing NAD(+) levels.
INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Vanessa Azevedo Voltarelli, Rodrigo W. Alves W. de Souza, Kenji Miyauchi, Carl J. Hauser, Leo Edmond Otterbein
Summary: Heme is an essential iron-protoporphyrin complex that plays a vital role in various cells and can have both harmful and beneficial effects. It can cause cytotoxicity in tissues and organs through pro-oxidant and pro-inflammatory responses, but it can also initiate specific cellular responses important for survival. This review focuses on heme metabolism and signaling pathways, including synthesis, degradation, scavenging, and its role in trauma and inflammatory diseases like traumatic brain injury, sepsis, cancer, and cardiovascular diseases.
Article
Immunology
Jing Tian, Yanan Li, Xing Mao, Keliang Xie, Yuxin Zheng, Yang Yu, Yonghao Yu
Summary: This study found that HO-1 plays a protective role in sepsis-induced lung injury in mice by regulating autophagy and activating the PI3K/Akt signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Junting Weng, Danjuan Liu, Bingbing Shi, Min Chen, Shuoyun Weng, Rongjie Guo, Xiaoping Zhou
Summary: This study investigated the therapeutic effects of the neutrophil elastase inhibitor Sivelestat sodium (SIV) in treating lipopolysaccharide (LPS)-induced acute lung injury (ALI) by improving endoplasmic reticulum stress (ERS). The results showed that SIV could improve ALI and suppress the LPS-induced ERS response.
Article
Medicine, Research & Experimental
Xiao Liu, Ling Wang, Qunzhi Xing, Kehan Li, Jianluo Si, Xiaowu Ma, Lianjing Mao
Summary: Sevoflurane exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating ferroptosis through up-regulating HO-1 expression, which may provide a possible mechanism for its application in clinical anesthesia.
Article
Oncology
Jie Cai, Zhenhua Sun, Lili Zhang, Hongrui Xu
Summary: This study investigated the role and mechanism of SERP1 in acute hepatic injury, finding that SERP1 regulates endoplasmic reticulum stress through the GSK3 beta/beta-catenin/TCF/LEF signaling pathway, reducing the occurrence of inchoate acute hepatic injury.
MOLECULAR MEDICINE REPORTS
(2022)
Editorial Material
Anesthesiology
C. C. Nestor, P. O. Sepulveda, M. G. Irwin
Review
Anesthesiology
R. L. H. Yim, K. M. M. Leung, C. C. M. Poon, M. G. Irwin
Summary: Parkinson's disease patients have a higher risk of peri-operative complications, necessitating multidisciplinary management and specialized care. Continuous dopaminergic treatment, peri-operative disease pathway development, and telemedicine are improving peri-operative care. Management for advanced Parkinson's disease is evolving with potential for integrated care and changes in anaesthetic management.
Review
Anesthesiology
C. C. Nestor, C. Ng, P. Sepulveda, M. G. Irwin
Summary: Mixing long- and short-acting local anaesthetics to hasten onset and extend duration may lead to ineffective solutions or potential harm due to pharmacokinetic principles; many local anaesthetic adjuncts are not approved for use, which can result in adverse events, and pharmaceutical compatibility needs to be confirmed before administration.
Review
Anesthesiology
C. K. E. Chung, C. C. M. Poon, M. G. Irwin
Summary: Surgery and anesthesia can cause stress to the brain, and monitoring with electroencephalography and cerebral oximetry can help assess anesthesia depth and cerebral metabolic activity. However, research results on the ability of these monitors to alleviate peri-operative neurocognitive complications have been contradictory. Understanding the changes in electroencephalography under anesthesia and those associated with aging is important for correctly interpreting anesthesia depth indices. Cerebral oximetry is useful for detecting cerebral desaturation and identifying higher-risk patients. An algorithm-based approach may be most effective in managing cerebral desaturation events.
Letter
Anesthesiology
C. C. Nestor, P. Sepulveda, M. G. Irwin
Letter
Anesthesiology
C. C. Nestor, P. Sepulveda, M. G. Irwin
Review
Pharmacology & Pharmacy
Qiu Qiu, Joshua C. J. Chew, Michael G. Irwin
Summary: Opioids are still important in postoperative analgesia, but the focus is on using them as part of multimodal regimens to avoid their complete use. The development of new drugs with more favorable adverse effect profiles may increase safety while maintaining efficacy.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Anesthesiology
Wendong Chen, Li Ma, Jianlin Shao, Chun Bi, Yuchen Xie, Shuangyan Zhao
Summary: This study analyzed the position-specific morphological changes of the upper airway and assessed their impact on difficult airway during intubation. The results showed that difficult airway had lower upper airway filling volumes compared to normal airway. Furthermore, the airway volume increased as the body position changed.
BMC ANESTHESIOLOGY
(2022)
Review
Anesthesiology
L. M. Hughes, M. G. Irwin, C. C. Nestor
Summary: Propfol-remifentanil-based total intravenous anaesthesia is commonly used in clinical practice due to its favorable pharmacokinetic profile. However, interruption in remifentanil supply presents an opportunity to explore alternative opioids and consider adjuncts to propofol-based anaesthesia. This article provides an overview of different opioids and their administration methods, as well as the role of non-opioid adjuncts in total intravenous anaesthesia.
Article
Anesthesiology
L. Q. Yang, L. Zhu, X. Shi, C. H. Miao, H. B. Yuan, Z. Q. Liu, W. D. Gu, F. Liu, X. X. Hu, D. P. Shi, H. W. Duan, C. Y. Wang, H. Weng, Z. L. Huang, L. Z. Li, Z. Z. He, J. Li, Y. P. Hu, L. Lin, S. T. Pan, S. H. Xu, D. Tang, D. I. Sessler, J. Liu, M. G. Irwin, W. F. Yu, POLMA-EP Investigators
Summary: In a clinical study, it was found that using a supraglottic airway device rather than a tracheal tube can reduce postoperative pulmonary complications in older patients undergoing non-cardiothoracic surgery under general anesthesia.
Article
Anesthesiology
W. Deng, C. C. Nestor, K. M. M. Leung, J. Chew, H. Wang, S. Wang, M. G. Irwin
Summary: The amount of aerosol generation from positive pressure ventilation via supraglottic airway devices in low-risk patients was quantified and compared to aerosol levels during conversation and coughing. The study found that the aerosol concentration generated by supraglottic airway insertion and removal was significantly lower than that produced during talking and coughing. The proportion of easily inhaled and small particles was also much lower during insertion and removal compared to talking and coughing.
Review
Medicine, General & Internal
Abigail Silva, Barbara Costa, Irene Castro, Joana Mourao, Nuno Vale
Summary: This review aims to discuss the current information on drug interactions in the perioperative period. Drug interactions during this period can affect the efficacy and safety of treatment. There are three types of drug interactions. It is important to recognize that drug interactions may increase toxicity and reduce efficacy, increasing the risk of complications. Thoroughly reviewing a patient's medication list and vigilant monitoring are essential in minimizing risks.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Becem Trabelsi, Azza Yedes, Ghada Kharrat, Hadhami Abdouli, Issam Mahouachi, Mohamed Ridha Saied, Mechaal Ben Ali
Summary: Negative-pressure pulmonary edema (NPPE) is a rare respiratory complication caused by acute upper airway obstruction shortly after extubation. This case report highlights the importance of early recognition and management of NPPE in young healthy patients, focusing on the misdiagnosis and subsequent treatment. The patient achieved full recovery through mechanical ventilation and diuretics.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)
Letter
Medicine, General & Internal
Claire C. Nestor, Michael G. Irwin
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Anesthesiology
Filipa D. M. F. Pinto, Michael G. Irwin
Summary: Since 2000, day surgery has experienced rapid expansion, driven by the target set by the NHS to perform 75% of surgeries as day procedures. Initially limited to elective surgeries, it now includes a pathway for emergency surgeries as well. Ambulatory surgery offers numerous advantages, but clear selection criteria, adherence to enhanced recovery protocols, and optimization of the patient's preoperative medical conditions are crucial for achieving good outcomes and minimizing complications.
ANAESTHESIA AND INTENSIVE CARE MEDICINE
(2022)