Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression

Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury

(2016) Walker M. McHugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

(2016) Andrew R. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells

(2016) Md. Mostafizur Rahman et al.   CELLULAR SIGNALLING

Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production

(2016) Yingying Yao et al.   MOLECULAR THERAPY

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

(2016) Sanguk Yun et al.   NATURE CELL BIOLOGY

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy

(2016) Isha N. Srivastava et al.   NEUROBIOLOGY OF DISEASE

Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice

(2016) Shushu Wang et al.   Parasites & Vectors

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

(2016) Zhao Dang et al.   ACS Medicinal Chemistry Letters

Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms

(2015) He Wang et al.   Journal of Hematology & Oncology

A potential role for regulatory T-cells in the amelioration of DSS induced colitis by dietary non-digestible polysaccharides

(2015) Anita Hartog et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

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(2015) Shuang Hu et al.   MOLECULAR MEDICINE

Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD)

(2015) B Mirlekar et al.   Mucosal Immunology

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

(2015) Dapeng Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21

(2015) Fei-Ran Gong et al.   Oncotarget

Aloperine attenuated neuropathic pain induced by chronic constriction injury via anti-oxidation activity and suppression of the nuclear factor kappa B pathway

(2014) Ya-Qiong Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection

(2014) Ying-Chun Lo et al.   Current Opinion in Organ Transplantation

Chinese Herbal Medicines in the Treatment of IBD and Colorectal Cancer: A Review

(2014) Maciej Sałaga et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells

(2014) LI ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

(2013) P Pandey et al.   BRITISH JOURNAL OF CANCER

PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer

(2013) M. W. Khan et al.   CLINICAL CANCER RESEARCH

Loss of Dicer Exacerbates Cyclophosphamide-Induced Bladder Overactivity by Enhancing Purinergic Signaling

(2012) Shu Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Loss of Methyl-CpG–Binding Domain Protein 2 Enhances Endothelial Angiogenesis and Protects Mice Against Hind-Limb Ischemic Injury

(2011) Xiaoquan Rao et al.   CIRCULATION

Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice

(2011) Xiao-Ying Yuan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

(2011) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Protein Phosphatase 2A Activity by PI3Kγ Regulates β-Adrenergic Receptor Function

(2011) Neelakantan T. Vasudevan et al.   MOLECULAR CELL

Total Alkaloids ofSophora alopecuroidesIncreases the Expression of CD4+CD25+Tregs and IL-10 in Rats with Experimental Colitis

(2010) Yi Zhou et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Generation, persistence and plasticity of CD4 T-cell memories

(2010) Jason R. Lees et al.   IMMUNOLOGY

Five Bitter Compounds Display Different Anti-inflammatory Effects through Modulating Cytokine Secretion Using Mouse Primary Splenocytes in Vitro

(2010) Wei-Chi Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hyperosmotic stress contributes to mouse colonic inflammation through the methylation of protein phosphatase 2A

(2008) Laurent Schwartz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY