Roles and potential clinical implications of tissue transglutaminase in cardiovascular diseases

Cystamine Treatment Fails to Prevent the Development of Pulmonary Hypertension in Chronic Hypoxic Rats

(2021) Lars K. Markvardsen et al.   JOURNAL OF VASCULAR RESEARCH

Probing tissue transglutaminase mediated vascular smooth muscle cell aging using a novel transamidation-deficient Tgm2-C277S mouse model

(2021) Huilei Wang et al.   Cell Death Discovery

Transglutaminase 2 Has Metabolic and Vascular Regulatory Functions Revealed by In Vivo Activation of Alpha1-Adrenergic Receptor

(2020) Kinga Lénárt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries

(2020) Estéfano Pinilla et al.   HYPERTENSION

Tissue Transglutaminase-Mediated AT1 Receptor Sensitization Underlies Pro-inflammatory Cytokine LIGHT-Induced Hypertension

(2019) Chen Liu et al.   AMERICAN JOURNAL OF HYPERTENSION

Food-related transglutaminase obtained from fish/shellfish

(2019) Yi Zhang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling

(2019) Chinmayee D. Bhedi et al.   FASEB JOURNAL

The role of transglutaminase 2 in mediating glial cell function and pathophysiology in the central nervous system

(2019) Jacob Rudlong et al.   ANALYTICAL BIOCHEMISTRY

Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency

(2019) Kathryn J. Griffin et al.   ATHEROSCLEROSIS

Cystamine slows but not inverses the progression of monocrotaline-induced pulmonary arterial hypertension in rats

(2018) Han-Ming Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche

(2018) Salvatore Condello et al.   CANCER RESEARCH

Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload

(2018) Arti V. Shinde et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transglutaminase 2: Friend or foe? The discordant role in neurons and astrocytes

(2018) Breandan R. Quinn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

(2018) Zhuo Wang et al.   Cell Death & Disease

Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice

(2018) Dinani Matoso Filho Armstrong et al.   Acta Cirurgica Brasileira

β 2 -adrenoceptor-induced modulation of transglutaminase 2 transamidase activity in cardiomyoblasts

(2017) Falguni S. Vyas et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking‐Dependent and Crosslinking‐Independent Functions

(2017) Jochen Steppan et al.   Journal of the American Heart Association

Role of tissue transglutaminase in age-associated ventricular stiffness

(2016) Young Jun Oh et al.   AMINO ACIDS

Transglutaminase as polyamine mediator in plant growth and differentiation

(2016) I. Aloisi et al.   AMINO ACIDS

Mechanical control of cardiac myofibroblasts

(2016) Sander van Putten et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney

(2016) Chi Hua Sarah Lin et al.   KIDNEY INTERNATIONAL

Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases

(2016) Carla Regina et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls

(2015) Humphrey G. Petersen-Jones et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Organizational Update: The World Health Organization Global Status Report on Noncommunicable Diseases 2014; One More Landmark Step in the Combat Against Stroke and Vascular Disease

(2015) S. Mendis et al.   STROKE

Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells

(2014) Krishna Penumatsa et al.   CELLULAR SIGNALLING

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Exercise, Vascular Stiffness, and Tissue Transglutaminase

(2014) Jochen Steppan et al.   Journal of the American Heart Association

Elevated Transglutaminase 2 Activity Is Associated with Hypoxia-Induced Experimental Pulmonary Hypertension in Mice

(2013) Thomas R. DiRaimondo et al.   ACS Chemical Biology

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice

(2013) Sung Mee Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transglutaminase 2-mediated serotonylation in pulmonary hypertension

(2013) K. C. Penumatsa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Expression of soluble recombinant transglutaminase from Zea mays in Pichia pastoris

(2013) Hongbo Li et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2

(2012) Kyle B. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Serotonylated fibronectin is elevated in pulmonary hypertension

(2012) Lin Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress

(2012) Hanke L. Matlung et al.   ATHEROSCLEROSIS

Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localization

(2012) Soner Gundemir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Treatment of Arterial Remodeling in Essential Hypertension

(2012) Marie Briet et al.   CURRENT HYPERTENSION REPORTS

Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: Evidence for a general mechanism of monoaminylation

(2012) René Hummerich et al.   FEBS LETTERS

Activation and Inhibition of Transglutaminase 2 in Mice

(2012) Laila Dafik et al.   PLoS One

Tissue Transglutaminase Constitutively Activates HIF-1α Promoter and Nuclear Factor-κB via a Non-Canonical Pathway

(2012) Santosh Kumar et al.   PLoS One

Nitric oxide regulates tissue transglutaminase localization and function in the vasculature

(2011) Simran K. Jandu et al.   AMINO ACIDS

Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells

(2011) Evgeny A. Zemskov et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myeloid-specific estrogen receptor   deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development

(2011) V. Ribas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2

(2011) Jiri Petrak et al.   Proteome Science

Left Ventricular Remodeling in Heart Failure

(2011) Marvin A. Konstam et al.   JACC-Cardiovascular Imaging

Role of Protein Transamidation in Serotonin-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells

(2010) Yinglin Liu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of transglutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice

(2010) Hanke L. Matlung et al.   ATHEROSCLEROSIS

Basic Science of Pulmonary Arterial Hypertension for Clinicians

(2010) Stephen L. Archer et al.   CIRCULATION

Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness

(2010) Lakshmi Santhanam et al.   CIRCULATION RESEARCH

Tissue transglutaminase 2 promotes apoptosis of rat neonatal cardiomyocytes under oxidative stress

(2010) Heesang Song et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

RhoA and Rho Kinase Activation in Human Pulmonary Hypertension

(2009) Christophe Guilluy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse

(2009) Helen Williams et al.   ATHEROSCLEROSIS

Transglutaminase 2 is involved in autophagosome maturation

(2009) Manuela D'Eletto et al.   Autophagy

Involvement of Tissue Transglutaminase in Endothelin 1–Induced Hypertrophy in Cultured Neonatal Rat Cardiomyocytes

(2009) Xin Li et al.   HYPERTENSION

Tissue Transglutaminase Is an Essential Participant in the Epidermal Growth Factor-stimulated Signaling Pathway Leading to Cancer Cell Migration and Invasion

(2009) Marc A. Antonyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transglutaminase 2 Deficiency Decreases Plaque Fibrosis and Increases Plaque Inflammation in Apolipoprotein-E-Deficient Mice

(2009) Jozef L. Van Herck et al.   JOURNAL OF VASCULAR RESEARCH

Serotonylation of Vascular Proteins Important to Contraction

(2009) Stephanie W. Watts et al.   PLoS One

Increased tissue transglutaminase expression in human atherosclerotic coronary arteries

(2008) Byung-Ryul Cho et al.   CORONARY ARTERY DISEASE

Substrate Preference of Transglutaminase 2 Revealed by Logistic Regression Analysis and Intrinsic Disorder Examination

(2008) Eva Csosz et al.   JOURNAL OF MOLECULAR BIOLOGY

Cystamine prevents ischemia–reperfusion injury by inhibiting polyamination of RhoA

(2007) Dong-Myung Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS